Decreased substance P content in the rectal mucosa of diabetics with diarrhea and constipation
Substance P (SP), vasoactive intestinal polypeptide (VIP), and somatostatin content in rectal mucosa were determined by radioimmunoassay (RIA) in 38 diabetic patients (12 with normal bowel function, 13 with diabetic diarrhea, and 13 with constipation) and in 10 nondiabetic crontrols with normal bowe...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 1997-07, Vol.46 (7), p.730-734 |
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| container_title | Metabolism, clinical and experimental |
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| creator | Lysy, Joseph Karmeli, Fanny Sestieri, Mirna Yatzkan, Yardena Goldin, Eran |
| description | Substance P (SP), vasoactive intestinal polypeptide (VIP), and somatostatin content in rectal mucosa were determined by radioimmunoassay (RIA) in 38 diabetic patients (12 with normal bowel function, 13 with diabetic diarrhea, and 13 with constipation) and in 10 nondiabetic crontrols with normal bowel funciton. SP content (picograms per milligram) in the rectal mucosa of diabetics with normal bowel funciton was significantly higher than that of nondiabetic controls (
P < .05). SP content in the rectal mucosa of diabetics with diabetic diarrhea and constipation was significantly lower than in diabetics with normal bowel habits and nondiabetic controls (
P < .05). No differences were found in the rectal mucosa content of VIP and somatostatin between the different groups of diabetics and controls. Diabetic diarrhea is a condition with an intermittent nature and frequently alternates with constipation. Our findings showing low levels of rectal mucosa SP in both conditions suggest a possible common role of SP in the pathogenesis of diabetic diarrhea and constipation. |
| doi_str_mv | 10.1016/S0026-0495(97)90114-1 |
| format | Article |
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P < .05). SP content in the rectal mucosa of diabetics with diabetic diarrhea and constipation was significantly lower than in diabetics with normal bowel habits and nondiabetic controls (
P < .05). No differences were found in the rectal mucosa content of VIP and somatostatin between the different groups of diabetics and controls. Diabetic diarrhea is a condition with an intermittent nature and frequently alternates with constipation. Our findings showing low levels of rectal mucosa SP in both conditions suggest a possible common role of SP in the pathogenesis of diabetic diarrhea and constipation.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1016/S0026-0495(97)90114-1</identifier><identifier>PMID: 9225823</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Associated diseases and complications ; Biological and medical sciences ; Constipation - complications ; Diabetes Complications ; Diabetes Mellitus - metabolism ; Diabetes. Impaired glucose tolerance ; Diarrhea - complications ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Humans ; Intestinal Mucosa - metabolism ; Male ; Medical sciences ; Middle Aged ; Rectum - metabolism ; Substance P - metabolism</subject><ispartof>Metabolism, clinical and experimental, 1997-07, Vol.46 (7), p.730-734</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-77f93af5efd917c4a5dd318be3d5cd1c9b7abb75b6c60cd11ac2c517e6195ed83</citedby><cites>FETCH-LOGICAL-c389t-77f93af5efd917c4a5dd318be3d5cd1c9b7abb75b6c60cd11ac2c517e6195ed83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0026-0495(97)90114-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2744528$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9225823$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lysy, Joseph</creatorcontrib><creatorcontrib>Karmeli, Fanny</creatorcontrib><creatorcontrib>Sestieri, Mirna</creatorcontrib><creatorcontrib>Yatzkan, Yardena</creatorcontrib><creatorcontrib>Goldin, Eran</creatorcontrib><title>Decreased substance P content in the rectal mucosa of diabetics with diarrhea and constipation</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>Substance P (SP), vasoactive intestinal polypeptide (VIP), and somatostatin content in rectal mucosa were determined by radioimmunoassay (RIA) in 38 diabetic patients (12 with normal bowel function, 13 with diabetic diarrhea, and 13 with constipation) and in 10 nondiabetic crontrols with normal bowel funciton. SP content (picograms per milligram) in the rectal mucosa of diabetics with normal bowel funciton was significantly higher than that of nondiabetic controls (
P < .05). SP content in the rectal mucosa of diabetics with diabetic diarrhea and constipation was significantly lower than in diabetics with normal bowel habits and nondiabetic controls (
P < .05). No differences were found in the rectal mucosa content of VIP and somatostatin between the different groups of diabetics and controls. Diabetic diarrhea is a condition with an intermittent nature and frequently alternates with constipation. Our findings showing low levels of rectal mucosa SP in both conditions suggest a possible common role of SP in the pathogenesis of diabetic diarrhea and constipation.</description><subject>Adult</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Constipation - complications</subject><subject>Diabetes Complications</subject><subject>Diabetes Mellitus - metabolism</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diarrhea - complications</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Rectum - metabolism</subject><subject>Substance P - metabolism</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVoSTdpfkJAh1KSg1NJtizrVEq-IdBA22uFPBqzKl57q5Fb8u9rZ5e99iRG87wzw8PYuRRXUsj60zchVF2IyuoLay6tkLIq5BFbSV2qoqmFeMNWB-QdOyH6JYQwpqmP2bFVSjeqXLGfNwgJPWHgNLWU_QDInzmMQ8Yh8zjwvEaeELLv-WaCkTwfOx6ibzFHIP435vVSprRGz_0QlizluPU5jsN79rbzPeHZ_j1lP-5uv18_FE9f7x-vvzwVUDY2F8Z0tvSdxi5YaaDyOoRSNi2WQUOQYFvj29botoZazB_SgwItDdbSagxNeco-7uZu0_h7QspuEwmw7_2A40TOWFkpUS6g3oGQRqKEndumuPHpxUnhFq_u1atbpDlr3KtXJ-fc-X7B1G4wHFJ7kXP_w77vCXzfpVlkpAOmTFVptaz_vMNwlvEnYnIEEWfnIS6OXRjjfw75B1nqlc8</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>Lysy, Joseph</creator><creator>Karmeli, Fanny</creator><creator>Sestieri, Mirna</creator><creator>Yatzkan, Yardena</creator><creator>Goldin, Eran</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970701</creationdate><title>Decreased substance P content in the rectal mucosa of diabetics with diarrhea and constipation</title><author>Lysy, Joseph ; Karmeli, Fanny ; Sestieri, Mirna ; Yatzkan, Yardena ; Goldin, Eran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-77f93af5efd917c4a5dd318be3d5cd1c9b7abb75b6c60cd11ac2c517e6195ed83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Constipation - complications</topic><topic>Diabetes Complications</topic><topic>Diabetes Mellitus - metabolism</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diarrhea - complications</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Rectum - metabolism</topic><topic>Substance P - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lysy, Joseph</creatorcontrib><creatorcontrib>Karmeli, Fanny</creatorcontrib><creatorcontrib>Sestieri, Mirna</creatorcontrib><creatorcontrib>Yatzkan, Yardena</creatorcontrib><creatorcontrib>Goldin, Eran</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lysy, Joseph</au><au>Karmeli, Fanny</au><au>Sestieri, Mirna</au><au>Yatzkan, Yardena</au><au>Goldin, Eran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased substance P content in the rectal mucosa of diabetics with diarrhea and constipation</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>1997-07-01</date><risdate>1997</risdate><volume>46</volume><issue>7</issue><spage>730</spage><epage>734</epage><pages>730-734</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>Substance P (SP), vasoactive intestinal polypeptide (VIP), and somatostatin content in rectal mucosa were determined by radioimmunoassay (RIA) in 38 diabetic patients (12 with normal bowel function, 13 with diabetic diarrhea, and 13 with constipation) and in 10 nondiabetic crontrols with normal bowel funciton. SP content (picograms per milligram) in the rectal mucosa of diabetics with normal bowel funciton was significantly higher than that of nondiabetic controls (
P < .05). SP content in the rectal mucosa of diabetics with diabetic diarrhea and constipation was significantly lower than in diabetics with normal bowel habits and nondiabetic controls (
P < .05). No differences were found in the rectal mucosa content of VIP and somatostatin between the different groups of diabetics and controls. Diabetic diarrhea is a condition with an intermittent nature and frequently alternates with constipation. Our findings showing low levels of rectal mucosa SP in both conditions suggest a possible common role of SP in the pathogenesis of diabetic diarrhea and constipation.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9225823</pmid><doi>10.1016/S0026-0495(97)90114-1</doi><tpages>5</tpages></addata></record> |
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| ispartof | Metabolism, clinical and experimental, 1997-07, Vol.46 (7), p.730-734 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Associated diseases and complications Biological and medical sciences Constipation - complications Diabetes Complications Diabetes Mellitus - metabolism Diabetes. Impaired glucose tolerance Diarrhea - complications Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Humans Intestinal Mucosa - metabolism Male Medical sciences Middle Aged Rectum - metabolism Substance P - metabolism |
| title | Decreased substance P content in the rectal mucosa of diabetics with diarrhea and constipation |
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