Adenovirus-mediated transfer of tissue-type plasminogen activator gene to human endothelial cells

Seeding of vascular grafts with genetically engineered human endothelial cells (hECs) secreting antithrombogenic or fibrinolytic agents has considerable clinical potential. An adenoviral vector was used to transfer the human tissue-type plasminogen activator (htPA) gene to hECs, and the ability of t...

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Veröffentlicht in:	Surgery 1997-07, Vol.122 (1), p.91-100
Hauptverfasser:	SUGAWARA, Y, SAKATA, Y, MIYATA, T, MINOWADA, S, HAMADA, H, YOSHIDA, Y, SATO, O, DEGUCHI, J.-O, KIMURA, H, NAMBA, T, MAKUUCHI, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adult Base Sequence Biological and medical sciences Cell Count Cells, Cultured Electrophoresis, Polyacrylamide Gel Endothelium, Vascular - chemistry Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fibrin - analysis Gene Expression - physiology Gene Transfer Techniques - standards Genetic Vectors Humans Immunoblotting Medical sciences Miscellaneous Polytetrafluoroethylene Prostheses and Implants Pulsatile Flow Saphenous Vein - cytology Sodium Dodecyl Sulfate Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Plasminogen Activator - analysis Tissue Plasminogen Activator - genetics Tissue Plasminogen Activator - metabolism
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