Differential effects of ammonia and β-methylene-DL-aspartate on metabolism of glutamate and related amino acids by astrocytes and neurons in primary culture

The effects of ammonium chloride (3 mM) and beta-methylene-DL-aspartate (BMA; 5 mM) (an inhibitor of aspartate aminotransferase, a key enzyme of the malate-aspartate shuttle (MAS] on the metabolism of glutamate and related amino acids were studied in primary cultures of astrocytes and neurons. Both...

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Veröffentlicht in:	Neurochemical research 1989-04, Vol.14 (4), p.377-389
Hauptverfasser:	LAI, J. C. K, MURTHY, C. R. K, COOPER, A. J. L, HERTZ, E, HERTZ, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Ammonia - pharmacology Animals Aspartic Acid - analogs & derivatives Aspartic Acid - pharmacology Astrocytes - drug effects Astrocytes - metabolism Biological and medical sciences Brain - cytology Brain - drug effects Brain - metabolism Cells, Cultured Fundamental and applied biological sciences. Psychology Glutamates - metabolism Glutamic Acid Isolated neuron and nerve. Neuroglia Mice Neurons - drug effects Neurons - metabolism Vertebrates: nervous system and sense organs
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