Development of Resistance of Human Immunodeficiency Virus Type 1 to Dextran Sulfate Associated with the Emergence of Specific Mutations in the Envelope gp120 Glycoprotein

Polyanionic compounds are known to inhibit the binding of human immunodeficiency virus (HIV) to CD4 + cells and the subsequent fusion step between the virus and cells. We selected an HIV-1 strain resistant to dextran sulfate (DS) by cultivation of HIV-1 (NL4–3)-infected MT-4 cells in the presence...

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Veröffentlicht in:	Molecular pharmacology 1997-07, Vol.52 (1), p.98-104
Hauptverfasser:	Este, J A, Schols, D, De Vreese, K, Van Laethem, K, Vandamme, A M, Desmyter, J, De Clercq, E
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Amino Acid Sequence Anti-HIV Agents - pharmacology Base Sequence Dextran Sulfate - pharmacology Drug Resistance Fluorescent Antibody Technique Genes, env HIV Envelope Protein gp120 - drug effects HIV Envelope Protein gp120 - genetics HIV-1 - drug effects human immunodeficiency virus 1 Humans Molecular Sequence Data Mutation
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