MRI detection of myocardial perfusion changes by gadolinium-DTPA infusion during dipyridamole hyperemia
To detect abnormal regional myocardial coronary flow reserve, serial spin‐echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a...
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| Veröffentlicht in: | Magnetic resonance in medicine 1989-05, Vol.10 (2), p.246-255 |
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| container_title | Magnetic resonance in medicine |
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| creator | Miller, D. Douglas Holmvang, Godtfred Gill, John B. Dragotakes, Donna Kantor, Howard L. Okada, Robert D. Brady, Thomas J. |
| description | To detect abnormal regional myocardial coronary flow reserve, serial spin‐echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium‐DTPA. Microsphere myocardial blood flow was measured for correlation with serial regional changes in MR signal intensity. Significant difference in gadolinium‐enhanced MR signal intensity existed between the hypoperfused LAD and the hyperemic left circumflex perfusion beds (46 ± 22% vs 78 ± 29% above baseline, respectively; P < 0.05). The percentage changes in gadolinium‐enhanced MR signal and microsphere myocardial blood flow were significantly correlated (r2 = 0.93). © 1989 Academic Press, Inc. |
| doi_str_mv | 10.1002/mrm.1910100209 |
| format | Article |
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Douglas ; Holmvang, Godtfred ; Gill, John B. ; Dragotakes, Donna ; Kantor, Howard L. ; Okada, Robert D. ; Brady, Thomas J.</creator><creatorcontrib>Miller, D. Douglas ; Holmvang, Godtfred ; Gill, John B. ; Dragotakes, Donna ; Kantor, Howard L. ; Okada, Robert D. ; Brady, Thomas J.</creatorcontrib><description>To detect abnormal regional myocardial coronary flow reserve, serial spin‐echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium‐DTPA. Microsphere myocardial blood flow was measured for correlation with serial regional changes in MR signal intensity. Significant difference in gadolinium‐enhanced MR signal intensity existed between the hypoperfused LAD and the hyperemic left circumflex perfusion beds (46 ± 22% vs 78 ± 29% above baseline, respectively; P < 0.05). The percentage changes in gadolinium‐enhanced MR signal and microsphere myocardial blood flow were significantly correlated (r2 = 0.93). © 1989 Academic Press, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.1910100209</identifier><identifier>PMID: 2761383</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>Baltimore: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; Cardiology. Vascular system ; Contrast Media ; Coronary Circulation - drug effects ; Coronary Disease - pathology ; Coronary Disease - physiopathology ; Coronary heart disease ; Dipyridamole - administration & dosage ; Disease Models, Animal ; Dogs ; Gadolinium ; Gadolinium DTPA ; Heart ; Hyperemia - physiopathology ; Magnetic Resonance Imaging ; Medical sciences ; Organometallic Compounds ; Pentetic Acid ; Vasodilation - drug effects</subject><ispartof>Magnetic resonance in medicine, 1989-05, Vol.10 (2), p.246-255</ispartof><rights>Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4739-bf7a8140e379af138cc3dd21f41a85faa1055fb26e03f02767d814f1d91971483</citedby><cites>FETCH-LOGICAL-c4739-bf7a8140e379af138cc3dd21f41a85faa1055fb26e03f02767d814f1d91971483</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.1910100209$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.1910100209$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7199859$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2761383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miller, D. Douglas</creatorcontrib><creatorcontrib>Holmvang, Godtfred</creatorcontrib><creatorcontrib>Gill, John B.</creatorcontrib><creatorcontrib>Dragotakes, Donna</creatorcontrib><creatorcontrib>Kantor, Howard L.</creatorcontrib><creatorcontrib>Okada, Robert D.</creatorcontrib><creatorcontrib>Brady, Thomas J.</creatorcontrib><title>MRI detection of myocardial perfusion changes by gadolinium-DTPA infusion during dipyridamole hyperemia</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>To detect abnormal regional myocardial coronary flow reserve, serial spin‐echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium‐DTPA. Microsphere myocardial blood flow was measured for correlation with serial regional changes in MR signal intensity. Significant difference in gadolinium‐enhanced MR signal intensity existed between the hypoperfused LAD and the hyperemic left circumflex perfusion beds (46 ± 22% vs 78 ± 29% above baseline, respectively; P < 0.05). The percentage changes in gadolinium‐enhanced MR signal and microsphere myocardial blood flow were significantly correlated (r2 = 0.93). © 1989 Academic Press, Inc.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Contrast Media</subject><subject>Coronary Circulation - drug effects</subject><subject>Coronary Disease - pathology</subject><subject>Coronary Disease - physiopathology</subject><subject>Coronary heart disease</subject><subject>Dipyridamole - administration & dosage</subject><subject>Disease Models, Animal</subject><subject>Dogs</subject><subject>Gadolinium</subject><subject>Gadolinium DTPA</subject><subject>Heart</subject><subject>Hyperemia - physiopathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Organometallic Compounds</subject><subject>Pentetic Acid</subject><subject>Vasodilation - drug effects</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1PGzEQxS3UClLKtbdKPlTcNvXHbrw-UgoBRGiFqJC4WBN_BNP1bmpn1e5_X0dZpeqJkzWe33sz8xD6QMmUEsI-hximVFKyLYg8QBNaMVawSpZv0ISIkhScyvIIvUvphRAipSgP0SETM8prPkGrxf01NnZj9cZ3Le4cDkOnIRoPDV7b6Pq0_dfP0K5swssBr8B0jW99H4qvD9_PsG9HxvTRtyts_HqI3kDoGoufh-xhg4f36K2DJtmT8T1GPy4vHs6vittv8-vzs9tCl4LLYukE1LQklgsJLq-oNTeGUVdSqCsHQElVuSWbWcIdyVcIk3FHjaRS0LLmx-h057uO3a_epo0KPmnbNNDark9KyGxaC5bB6Q7UsUspWqfW0QeIg6JEbcNUOVn1L9ks-Dg698tgzR4fo8z9T2MfkobGRWi1T3tMUCnramsjd9hv39jhlaFqcb_4b4Vip_VpY__stRB_qpngolKPd3N1yZ4Yq2--qDn_CyVYoTA</recordid><startdate>198905</startdate><enddate>198905</enddate><creator>Miller, D. Douglas</creator><creator>Holmvang, Godtfred</creator><creator>Gill, John B.</creator><creator>Dragotakes, Donna</creator><creator>Kantor, Howard L.</creator><creator>Okada, Robert D.</creator><creator>Brady, Thomas J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198905</creationdate><title>MRI detection of myocardial perfusion changes by gadolinium-DTPA infusion during dipyridamole hyperemia</title><author>Miller, D. Douglas ; Holmvang, Godtfred ; Gill, John B. ; Dragotakes, Donna ; Kantor, Howard L. ; Okada, Robert D. ; Brady, Thomas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4739-bf7a8140e379af138cc3dd21f41a85faa1055fb26e03f02767d814f1d91971483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Contrast Media</topic><topic>Coronary Circulation - drug effects</topic><topic>Coronary Disease - pathology</topic><topic>Coronary Disease - physiopathology</topic><topic>Coronary heart disease</topic><topic>Dipyridamole - administration & dosage</topic><topic>Disease Models, Animal</topic><topic>Dogs</topic><topic>Gadolinium</topic><topic>Gadolinium DTPA</topic><topic>Heart</topic><topic>Hyperemia - physiopathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Organometallic Compounds</topic><topic>Pentetic Acid</topic><topic>Vasodilation - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miller, D. Douglas</creatorcontrib><creatorcontrib>Holmvang, Godtfred</creatorcontrib><creatorcontrib>Gill, John B.</creatorcontrib><creatorcontrib>Dragotakes, Donna</creatorcontrib><creatorcontrib>Kantor, Howard L.</creatorcontrib><creatorcontrib>Okada, Robert D.</creatorcontrib><creatorcontrib>Brady, Thomas J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miller, D. Douglas</au><au>Holmvang, Godtfred</au><au>Gill, John B.</au><au>Dragotakes, Donna</au><au>Kantor, Howard L.</au><au>Okada, Robert D.</au><au>Brady, Thomas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MRI detection of myocardial perfusion changes by gadolinium-DTPA infusion during dipyridamole hyperemia</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1989-05</date><risdate>1989</risdate><volume>10</volume><issue>2</issue><spage>246</spage><epage>255</epage><pages>246-255</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>To detect abnormal regional myocardial coronary flow reserve, serial spin‐echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium‐DTPA. Microsphere myocardial blood flow was measured for correlation with serial regional changes in MR signal intensity. Significant difference in gadolinium‐enhanced MR signal intensity existed between the hypoperfused LAD and the hyperemic left circumflex perfusion beds (46 ± 22% vs 78 ± 29% above baseline, respectively; P < 0.05). The percentage changes in gadolinium‐enhanced MR signal and microsphere myocardial blood flow were significantly correlated (r2 = 0.93). © 1989 Academic Press, Inc.</abstract><cop>Baltimore</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>2761383</pmid><doi>10.1002/mrm.1910100209</doi><tpages>10</tpages></addata></record> |
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| ispartof | Magnetic resonance in medicine, 1989-05, Vol.10 (2), p.246-255 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biological and medical sciences Cardiology. Vascular system Contrast Media Coronary Circulation - drug effects Coronary Disease - pathology Coronary Disease - physiopathology Coronary heart disease Dipyridamole - administration & dosage Disease Models, Animal Dogs Gadolinium Gadolinium DTPA Heart Hyperemia - physiopathology Magnetic Resonance Imaging Medical sciences Organometallic Compounds Pentetic Acid Vasodilation - drug effects |
| title | MRI detection of myocardial perfusion changes by gadolinium-DTPA infusion during dipyridamole hyperemia |
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