Longitudinal manganese and copper balances in young infants and preterm infants fed on breast-milk and adapted cow's milk formulas
1. Mn and Cu intake and retention in twenty full-term infants and six preterm infants were studied on the basis of 72 h balances. The age of the infants was 2-16 weeks and the gestational age of the preterm infants (triplets) 34 and 36 weeks. Three nutrition schemes were pursued: breast-fed, formula...
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| Veröffentlicht in: | British journal of nutrition 1989-05, Vol.61 (3), p.559-572 |
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| description | 1. Mn and Cu intake and retention in twenty full-term infants and six preterm infants were studied on the basis of 72 h balances. The age of the infants was 2-16 weeks and the gestational age of the preterm infants (triplets) 34 and 36 weeks. Three nutrition schemes were pursued: breast-fed, formula-fed with unsupplemented adapted formula and formula-fed with trace element supplementation. 2. The mean Mn concentration of all breast-milk samples (n 2339) was 6.2 micrograms/l. The two formulas had similar Mn concentrations (77 and 99 micrograms/l) but had different Fe, Cu (121 and 619 micrograms/l), Zn and I contents. The mean Cu concentration in mother's milk was 833 micrograms/l. 3. The following mean daily Mn intakes and retentions (micrograms/kg) respectively were measured: breast-fed full-term 1.06 (SD 0.43) and 0.43 (SD 0.65), formula-fed full-term 14.2 (SD 3.1) and 2.8 (SD 4.8), formula-fed preterm 15.0 (SD 2.2) and 0.06 (SD 5.87). The results for Cu were 114.5 (SD 22.3) and 88.0 (SD 46.5) micrograms/kg in breast-fed, 19.8 (SD 4.2) and 4.6 (-11.5-9.6) in the unsupplemented formula-fed and 106.4 (SD 18.9) and 55.5 (SD 20.3) in the supplemented formula full-term infant group. No significant influence of the trace element contents of the formulas on the relative retention of Mn or Cu was found. 4. Young preterm infants, and to some degree young full-term infants, often had negative Mn balances caused by a high faecal excretion. The formulas with a Mn concentration below 100 micrograms/l gave a sufficient supply of Mn. Preterm infants fed on the unsupplemented formula had a marginal Cu supply and their first balances were negative (-3.8 (SD 1.8) micrograms/kg). 5. In accordance with the estimated safe and adequate daily dietary intakes (recommended dietary allowances), formula-fed infants receive much more Mn than breast-fed infants and their absolute retention is higher. 6. Cu from breast-milk had a significantly better biological availability than that from cow's milk formula. If retentions similar to those in breast-fed infants are intended, we conclude, therefore, that cow's milk formula should be fortified with Cu up to a level of at least 600 micrograms/l. |
| doi_str_mv | 10.1079/BJN19890143 |
| format | Article |
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Mn and Cu intake and retention in twenty full-term infants and six preterm infants were studied on the basis of 72 h balances. The age of the infants was 2-16 weeks and the gestational age of the preterm infants (triplets) 34 and 36 weeks. Three nutrition schemes were pursued: breast-fed, formula-fed with unsupplemented adapted formula and formula-fed with trace element supplementation. 2. The mean Mn concentration of all breast-milk samples (n 2339) was 6.2 micrograms/l. The two formulas had similar Mn concentrations (77 and 99 micrograms/l) but had different Fe, Cu (121 and 619 micrograms/l), Zn and I contents. The mean Cu concentration in mother's milk was 833 micrograms/l. 3. The following mean daily Mn intakes and retentions (micrograms/kg) respectively were measured: breast-fed full-term 1.06 (SD 0.43) and 0.43 (SD 0.65), formula-fed full-term 14.2 (SD 3.1) and 2.8 (SD 4.8), formula-fed preterm 15.0 (SD 2.2) and 0.06 (SD 5.87). The results for Cu were 114.5 (SD 22.3) and 88.0 (SD 46.5) micrograms/kg in breast-fed, 19.8 (SD 4.2) and 4.6 (-11.5-9.6) in the unsupplemented formula-fed and 106.4 (SD 18.9) and 55.5 (SD 20.3) in the supplemented formula full-term infant group. No significant influence of the trace element contents of the formulas on the relative retention of Mn or Cu was found. 4. Young preterm infants, and to some degree young full-term infants, often had negative Mn balances caused by a high faecal excretion. The formulas with a Mn concentration below 100 micrograms/l gave a sufficient supply of Mn. Preterm infants fed on the unsupplemented formula had a marginal Cu supply and their first balances were negative (-3.8 (SD 1.8) micrograms/kg). 5. In accordance with the estimated safe and adequate daily dietary intakes (recommended dietary allowances), formula-fed infants receive much more Mn than breast-fed infants and their absolute retention is higher. 6. Cu from breast-milk had a significantly better biological availability than that from cow's milk formula. If retentions similar to those in breast-fed infants are intended, we conclude, therefore, that cow's milk formula should be fortified with Cu up to a level of at least 600 micrograms/l.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN19890143</identifier><identifier>PMID: 2758010</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Wallingford: Cambridge University Press</publisher><subject>Animals ; Biological and medical sciences ; Breast Feeding ; Copper - metabolism ; Feces - analysis ; Feeding. Feeding behavior ; Food, Fortified ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant ; Infant, Newborn ; Infant, Premature - metabolism ; Iodine - metabolism ; Iron - metabolism ; Male ; Manganese - metabolism ; Milk - metabolism ; Milk, Human - metabolism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Zinc - metabolism</subject><ispartof>British journal of nutrition, 1989-05, Vol.61 (3), p.559-572</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7277779$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2758010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DÖRNER, K</creatorcontrib><creatorcontrib>DZIADZKA, S</creatorcontrib><creatorcontrib>HÖHN, A</creatorcontrib><creatorcontrib>SIEVERS, E</creatorcontrib><creatorcontrib>OLDIGS, H.-D</creatorcontrib><creatorcontrib>SHULZ-LELL, G</creatorcontrib><creatorcontrib>SCHAUB, J</creatorcontrib><title>Longitudinal manganese and copper balances in young infants and preterm infants fed on breast-milk and adapted cow's milk formulas</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>1. Mn and Cu intake and retention in twenty full-term infants and six preterm infants were studied on the basis of 72 h balances. The age of the infants was 2-16 weeks and the gestational age of the preterm infants (triplets) 34 and 36 weeks. Three nutrition schemes were pursued: breast-fed, formula-fed with unsupplemented adapted formula and formula-fed with trace element supplementation. 2. The mean Mn concentration of all breast-milk samples (n 2339) was 6.2 micrograms/l. The two formulas had similar Mn concentrations (77 and 99 micrograms/l) but had different Fe, Cu (121 and 619 micrograms/l), Zn and I contents. The mean Cu concentration in mother's milk was 833 micrograms/l. 3. The following mean daily Mn intakes and retentions (micrograms/kg) respectively were measured: breast-fed full-term 1.06 (SD 0.43) and 0.43 (SD 0.65), formula-fed full-term 14.2 (SD 3.1) and 2.8 (SD 4.8), formula-fed preterm 15.0 (SD 2.2) and 0.06 (SD 5.87). The results for Cu were 114.5 (SD 22.3) and 88.0 (SD 46.5) micrograms/kg in breast-fed, 19.8 (SD 4.2) and 4.6 (-11.5-9.6) in the unsupplemented formula-fed and 106.4 (SD 18.9) and 55.5 (SD 20.3) in the supplemented formula full-term infant group. No significant influence of the trace element contents of the formulas on the relative retention of Mn or Cu was found. 4. Young preterm infants, and to some degree young full-term infants, often had negative Mn balances caused by a high faecal excretion. The formulas with a Mn concentration below 100 micrograms/l gave a sufficient supply of Mn. Preterm infants fed on the unsupplemented formula had a marginal Cu supply and their first balances were negative (-3.8 (SD 1.8) micrograms/kg). 5. In accordance with the estimated safe and adequate daily dietary intakes (recommended dietary allowances), formula-fed infants receive much more Mn than breast-fed infants and their absolute retention is higher. 6. Cu from breast-milk had a significantly better biological availability than that from cow's milk formula. If retentions similar to those in breast-fed infants are intended, we conclude, therefore, that cow's milk formula should be fortified with Cu up to a level of at least 600 micrograms/l.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Breast Feeding</subject><subject>Copper - metabolism</subject><subject>Feces - analysis</subject><subject>Feeding. Feeding behavior</subject><subject>Food, Fortified</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - metabolism</subject><subject>Iodine - metabolism</subject><subject>Iron - metabolism</subject><subject>Male</subject><subject>Manganese - metabolism</subject><subject>Milk - metabolism</subject><subject>Milk, Human - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Zinc - metabolism</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kL1PwzAQxS0EKqUwMSN5QDAF_FHH8QgVn6pggTm6OOcqkDjBToS68pcTStVb7u69n550R8gpZ1ecaXN9-_zCTWYYn8s9MuVzrRKRpmKfTBljOuF8rg7JUYwf45pxZiZkIrTKGGdT8rNs_arqh7LyUNMG_Ao8RqTgS2rbrsNAC6jBW4y08nTdDn41Dg58HzdQF7DH0Ow0hyVtPS0CQuyTpqo_NxiU0PX4l_l9GelGdm1ohhriMTlwUEc82fYZeb-_e1s8JsvXh6fFzTLphFR9ks4L43gqMnTWFRw5aq6UQZfZTIlCSM7SgmcyQ2GUsYhSKCcBpAVlGRRyRi7-c7vQfg0Y-7yposV6vA7bIebacKmVMSN4tgWHosEy70LVQFjn26eN_vnWh2ihdmF8TxV3mBZ6LCN_AawefIU</recordid><startdate>19890501</startdate><enddate>19890501</enddate><creator>DÖRNER, K</creator><creator>DZIADZKA, S</creator><creator>HÖHN, A</creator><creator>SIEVERS, E</creator><creator>OLDIGS, H.-D</creator><creator>SHULZ-LELL, G</creator><creator>SCHAUB, J</creator><general>Cambridge University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19890501</creationdate><title>Longitudinal manganese and copper balances in young infants and preterm infants fed on breast-milk and adapted cow's milk formulas</title><author>DÖRNER, K ; DZIADZKA, S ; HÖHN, A ; SIEVERS, E ; OLDIGS, H.-D ; SHULZ-LELL, G ; SCHAUB, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-64b9f1628efcfb1e1e71559ef8c852b23106b1838e2959cee325f3aa3ca5c0ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Breast Feeding</topic><topic>Copper - metabolism</topic><topic>Feces - analysis</topic><topic>Feeding. Feeding behavior</topic><topic>Food, Fortified</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - metabolism</topic><topic>Iodine - metabolism</topic><topic>Iron - metabolism</topic><topic>Male</topic><topic>Manganese - metabolism</topic><topic>Milk - metabolism</topic><topic>Milk, Human - metabolism</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DÖRNER, K</creatorcontrib><creatorcontrib>DZIADZKA, S</creatorcontrib><creatorcontrib>HÖHN, A</creatorcontrib><creatorcontrib>SIEVERS, E</creatorcontrib><creatorcontrib>OLDIGS, H.-D</creatorcontrib><creatorcontrib>SHULZ-LELL, G</creatorcontrib><creatorcontrib>SCHAUB, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DÖRNER, K</au><au>DZIADZKA, S</au><au>HÖHN, A</au><au>SIEVERS, E</au><au>OLDIGS, H.-D</au><au>SHULZ-LELL, G</au><au>SCHAUB, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal manganese and copper balances in young infants and preterm infants fed on breast-milk and adapted cow's milk formulas</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>1989-05-01</date><risdate>1989</risdate><volume>61</volume><issue>3</issue><spage>559</spage><epage>572</epage><pages>559-572</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>1. Mn and Cu intake and retention in twenty full-term infants and six preterm infants were studied on the basis of 72 h balances. The age of the infants was 2-16 weeks and the gestational age of the preterm infants (triplets) 34 and 36 weeks. Three nutrition schemes were pursued: breast-fed, formula-fed with unsupplemented adapted formula and formula-fed with trace element supplementation. 2. The mean Mn concentration of all breast-milk samples (n 2339) was 6.2 micrograms/l. The two formulas had similar Mn concentrations (77 and 99 micrograms/l) but had different Fe, Cu (121 and 619 micrograms/l), Zn and I contents. The mean Cu concentration in mother's milk was 833 micrograms/l. 3. The following mean daily Mn intakes and retentions (micrograms/kg) respectively were measured: breast-fed full-term 1.06 (SD 0.43) and 0.43 (SD 0.65), formula-fed full-term 14.2 (SD 3.1) and 2.8 (SD 4.8), formula-fed preterm 15.0 (SD 2.2) and 0.06 (SD 5.87). The results for Cu were 114.5 (SD 22.3) and 88.0 (SD 46.5) micrograms/kg in breast-fed, 19.8 (SD 4.2) and 4.6 (-11.5-9.6) in the unsupplemented formula-fed and 106.4 (SD 18.9) and 55.5 (SD 20.3) in the supplemented formula full-term infant group. No significant influence of the trace element contents of the formulas on the relative retention of Mn or Cu was found. 4. Young preterm infants, and to some degree young full-term infants, often had negative Mn balances caused by a high faecal excretion. The formulas with a Mn concentration below 100 micrograms/l gave a sufficient supply of Mn. Preterm infants fed on the unsupplemented formula had a marginal Cu supply and their first balances were negative (-3.8 (SD 1.8) micrograms/kg). 5. In accordance with the estimated safe and adequate daily dietary intakes (recommended dietary allowances), formula-fed infants receive much more Mn than breast-fed infants and their absolute retention is higher. 6. Cu from breast-milk had a significantly better biological availability than that from cow's milk formula. If retentions similar to those in breast-fed infants are intended, we conclude, therefore, that cow's milk formula should be fortified with Cu up to a level of at least 600 micrograms/l.</abstract><cop>Wallingford</cop><pub>Cambridge University Press</pub><pmid>2758010</pmid><doi>10.1079/BJN19890143</doi><tpages>14</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Breast Feeding Copper - metabolism Feces - analysis Feeding. Feeding behavior Food, Fortified Fundamental and applied biological sciences. Psychology Humans Infant Infant, Newborn Infant, Premature - metabolism Iodine - metabolism Iron - metabolism Male Manganese - metabolism Milk - metabolism Milk, Human - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems Zinc - metabolism |
| title | Longitudinal manganese and copper balances in young infants and preterm infants fed on breast-milk and adapted cow's milk formulas |
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