Plasma cell malignancy in the acquired immune deficiency syndrome: association with Epstein-Barr virus
The development of high-grade, malignant B-cell lymphoma is a well-recognized complication of human immunodeficiency virus (HIV) infection. Plasma cell neoplasms, however, have been rarely encountered in HIV-infected people. This study presents the morphologic and immunologic features of an unusual...
Gespeichert in:
| Veröffentlicht in: | American journal of clinical pathology 1989-08, Vol.92 (2), p.222-228 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 228 |
|---|---|
| container_issue | 2 |
| container_start_page | 222 |
| container_title | American journal of clinical pathology |
| container_volume | 92 |
| creator | VOELKERDING, K. V SANDHAUS, L. M KIM, H. C WILSON, J CHITTENDEN, T LEVINE, A. J RASKA, K. JR |
| description | The development of high-grade, malignant B-cell lymphoma is a well-recognized complication of human immunodeficiency virus (HIV) infection. Plasma cell neoplasms, however, have been rarely encountered in HIV-infected people. This study presents the morphologic and immunologic features of an unusual plasma cell tumor occurring in a 31-year-old HIV-antibody-positive male. The malignancy was characterized by widespread dissemination and hypercalcemia at presentation and a clinically aggressive course. Immunoperoxidase staining of tumor tissue obtained from biopsy and at autopsy had positive results for IgM and lambda. In the patient's serum, only an IgG kappa paraprotein was detected, indicating that the tumor was nonsecretory. DNA analysis of autopsy-derived tumor tissues demonstrated clonal rearrangements of the immunoglobulin (Ig) heavy chain gene locus and rearrangements in both kappa and lambda light chain gene loci. Furthermore, DNA hybridization studies revealed the presence of Epstein-Barr virus (EBV) genomes in tumor tissue but not in nontumor tissue from this patient. |
| doi_str_mv | 10.1093/ajcp/92.2.222 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79137471</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79137471</sourcerecordid><originalsourceid>FETCH-LOGICAL-c348t-89224ea6f30bdc41dd89346a94ff8b57c989b5d2dce018585ffd6f8a382472573</originalsourceid><addsrcrecordid>eNqFkTlPAzEUhC0ECiFQUiK5QHSb-NrYpgPEJUWCAurViw_iaI_E3gXl37MhUVo0xSvm00hvBqFLSsaUaD6BpVlNNBv3YuwIDakWPJOSsWM0JISwTFPJT9FZSktCKFNEDNCA5UJyoofIv5eQKsDGlSWuoAxfNdRmg0ON24XDYNZdiM7iUFVd7bB1PpjgtkTa1DY2lbvFkFJjArShqfFPaBf4cZVaF-rsHmLE3yF26RydeCiTu9jfEfp8evx4eMlmb8-vD3ezzHCh2kxpxoSDqedkbo2g1irNxRS08F7Nc2m00vPcMmscoSpXufd26hVwxYRkueQjdLPLXcVm3bnUFlVI29-gdk2XCqkpl0LSf0Gac074H5jtQBOblKLzxSqGCuKmoKTYDlBsByg0K3ox1vNX--BuXjl7oPeN9_713odkoPSxrzukAyY55UQI_gtPZY8r</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15330371</pqid></control><display><type>article</type><title>Plasma cell malignancy in the acquired immune deficiency syndrome: association with Epstein-Barr virus</title><source>MEDLINE</source><source>Oxford University Press Journals Digital Archive Legacy</source><creator>VOELKERDING, K. V ; SANDHAUS, L. M ; KIM, H. C ; WILSON, J ; CHITTENDEN, T ; LEVINE, A. J ; RASKA, K. JR</creator><creatorcontrib>VOELKERDING, K. V ; SANDHAUS, L. M ; KIM, H. C ; WILSON, J ; CHITTENDEN, T ; LEVINE, A. J ; RASKA, K. JR</creatorcontrib><description>The development of high-grade, malignant B-cell lymphoma is a well-recognized complication of human immunodeficiency virus (HIV) infection. Plasma cell neoplasms, however, have been rarely encountered in HIV-infected people. This study presents the morphologic and immunologic features of an unusual plasma cell tumor occurring in a 31-year-old HIV-antibody-positive male. The malignancy was characterized by widespread dissemination and hypercalcemia at presentation and a clinically aggressive course. Immunoperoxidase staining of tumor tissue obtained from biopsy and at autopsy had positive results for IgM and lambda. In the patient's serum, only an IgG kappa paraprotein was detected, indicating that the tumor was nonsecretory. DNA analysis of autopsy-derived tumor tissues demonstrated clonal rearrangements of the immunoglobulin (Ig) heavy chain gene locus and rearrangements in both kappa and lambda light chain gene loci. Furthermore, DNA hybridization studies revealed the presence of Epstein-Barr virus (EBV) genomes in tumor tissue but not in nontumor tissue from this patient.</description><identifier>ISSN: 0002-9173</identifier><identifier>EISSN: 1943-7722</identifier><identifier>DOI: 10.1093/ajcp/92.2.222</identifier><identifier>PMID: 2547309</identifier><identifier>CODEN: AJCPAI</identifier><language>eng</language><publisher>Chicago, IL: American Society of Clinical Pathologists</publisher><subject>Acquired Immunodeficiency Syndrome - genetics ; Adult ; AIDS/HIV ; Biological and medical sciences ; DNA, Viral - genetics ; Epstein-Barr virus ; Gene Rearrangement ; Herpesvirus 4, Human - genetics ; Humans ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulin Heavy Chains - genetics ; Immunoglobulin kappa-Chains - genetics ; Immunoglobulin lambda-Chains - genetics ; Immunoglobulin M - genetics ; Immunopathology ; Lymphoma, Non-Hodgkin - genetics ; Lymphoma, Non-Hodgkin - microbiology ; Male ; Medical sciences ; Multiple Myeloma - genetics ; Multiple Myeloma - microbiology</subject><ispartof>American journal of clinical pathology, 1989-08, Vol.92 (2), p.222-228</ispartof><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-89224ea6f30bdc41dd89346a94ff8b57c989b5d2dce018585ffd6f8a382472573</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7313044$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2547309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VOELKERDING, K. V</creatorcontrib><creatorcontrib>SANDHAUS, L. M</creatorcontrib><creatorcontrib>KIM, H. C</creatorcontrib><creatorcontrib>WILSON, J</creatorcontrib><creatorcontrib>CHITTENDEN, T</creatorcontrib><creatorcontrib>LEVINE, A. J</creatorcontrib><creatorcontrib>RASKA, K. JR</creatorcontrib><title>Plasma cell malignancy in the acquired immune deficiency syndrome: association with Epstein-Barr virus</title><title>American journal of clinical pathology</title><addtitle>Am J Clin Pathol</addtitle><description>The development of high-grade, malignant B-cell lymphoma is a well-recognized complication of human immunodeficiency virus (HIV) infection. Plasma cell neoplasms, however, have been rarely encountered in HIV-infected people. This study presents the morphologic and immunologic features of an unusual plasma cell tumor occurring in a 31-year-old HIV-antibody-positive male. The malignancy was characterized by widespread dissemination and hypercalcemia at presentation and a clinically aggressive course. Immunoperoxidase staining of tumor tissue obtained from biopsy and at autopsy had positive results for IgM and lambda. In the patient's serum, only an IgG kappa paraprotein was detected, indicating that the tumor was nonsecretory. DNA analysis of autopsy-derived tumor tissues demonstrated clonal rearrangements of the immunoglobulin (Ig) heavy chain gene locus and rearrangements in both kappa and lambda light chain gene loci. Furthermore, DNA hybridization studies revealed the presence of Epstein-Barr virus (EBV) genomes in tumor tissue but not in nontumor tissue from this patient.</description><subject>Acquired Immunodeficiency Syndrome - genetics</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>DNA, Viral - genetics</subject><subject>Epstein-Barr virus</subject><subject>Gene Rearrangement</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Humans</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulin Heavy Chains - genetics</subject><subject>Immunoglobulin kappa-Chains - genetics</subject><subject>Immunoglobulin lambda-Chains - genetics</subject><subject>Immunoglobulin M - genetics</subject><subject>Immunopathology</subject><subject>Lymphoma, Non-Hodgkin - genetics</subject><subject>Lymphoma, Non-Hodgkin - microbiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multiple Myeloma - genetics</subject><subject>Multiple Myeloma - microbiology</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTlPAzEUhC0ECiFQUiK5QHSb-NrYpgPEJUWCAurViw_iaI_E3gXl37MhUVo0xSvm00hvBqFLSsaUaD6BpVlNNBv3YuwIDakWPJOSsWM0JISwTFPJT9FZSktCKFNEDNCA5UJyoofIv5eQKsDGlSWuoAxfNdRmg0ON24XDYNZdiM7iUFVd7bB1PpjgtkTa1DY2lbvFkFJjArShqfFPaBf4cZVaF-rsHmLE3yF26RydeCiTu9jfEfp8evx4eMlmb8-vD3ezzHCh2kxpxoSDqedkbo2g1irNxRS08F7Nc2m00vPcMmscoSpXufd26hVwxYRkueQjdLPLXcVm3bnUFlVI29-gdk2XCqkpl0LSf0Gac074H5jtQBOblKLzxSqGCuKmoKTYDlBsByg0K3ox1vNX--BuXjl7oPeN9_713odkoPSxrzukAyY55UQI_gtPZY8r</recordid><startdate>19890801</startdate><enddate>19890801</enddate><creator>VOELKERDING, K. V</creator><creator>SANDHAUS, L. M</creator><creator>KIM, H. C</creator><creator>WILSON, J</creator><creator>CHITTENDEN, T</creator><creator>LEVINE, A. J</creator><creator>RASKA, K. JR</creator><general>American Society of Clinical Pathologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19890801</creationdate><title>Plasma cell malignancy in the acquired immune deficiency syndrome: association with Epstein-Barr virus</title><author>VOELKERDING, K. V ; SANDHAUS, L. M ; KIM, H. C ; WILSON, J ; CHITTENDEN, T ; LEVINE, A. J ; RASKA, K. JR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-89224ea6f30bdc41dd89346a94ff8b57c989b5d2dce018585ffd6f8a382472573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Acquired Immunodeficiency Syndrome - genetics</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>DNA, Viral - genetics</topic><topic>Epstein-Barr virus</topic><topic>Gene Rearrangement</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Humans</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulin Heavy Chains - genetics</topic><topic>Immunoglobulin kappa-Chains - genetics</topic><topic>Immunoglobulin lambda-Chains - genetics</topic><topic>Immunoglobulin M - genetics</topic><topic>Immunopathology</topic><topic>Lymphoma, Non-Hodgkin - genetics</topic><topic>Lymphoma, Non-Hodgkin - microbiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multiple Myeloma - genetics</topic><topic>Multiple Myeloma - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VOELKERDING, K. V</creatorcontrib><creatorcontrib>SANDHAUS, L. M</creatorcontrib><creatorcontrib>KIM, H. C</creatorcontrib><creatorcontrib>WILSON, J</creatorcontrib><creatorcontrib>CHITTENDEN, T</creatorcontrib><creatorcontrib>LEVINE, A. J</creatorcontrib><creatorcontrib>RASKA, K. JR</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VOELKERDING, K. V</au><au>SANDHAUS, L. M</au><au>KIM, H. C</au><au>WILSON, J</au><au>CHITTENDEN, T</au><au>LEVINE, A. J</au><au>RASKA, K. JR</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma cell malignancy in the acquired immune deficiency syndrome: association with Epstein-Barr virus</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1989-08-01</date><risdate>1989</risdate><volume>92</volume><issue>2</issue><spage>222</spage><epage>228</epage><pages>222-228</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><coden>AJCPAI</coden><abstract>The development of high-grade, malignant B-cell lymphoma is a well-recognized complication of human immunodeficiency virus (HIV) infection. Plasma cell neoplasms, however, have been rarely encountered in HIV-infected people. This study presents the morphologic and immunologic features of an unusual plasma cell tumor occurring in a 31-year-old HIV-antibody-positive male. The malignancy was characterized by widespread dissemination and hypercalcemia at presentation and a clinically aggressive course. Immunoperoxidase staining of tumor tissue obtained from biopsy and at autopsy had positive results for IgM and lambda. In the patient's serum, only an IgG kappa paraprotein was detected, indicating that the tumor was nonsecretory. DNA analysis of autopsy-derived tumor tissues demonstrated clonal rearrangements of the immunoglobulin (Ig) heavy chain gene locus and rearrangements in both kappa and lambda light chain gene loci. Furthermore, DNA hybridization studies revealed the presence of Epstein-Barr virus (EBV) genomes in tumor tissue but not in nontumor tissue from this patient.</abstract><cop>Chicago, IL</cop><pub>American Society of Clinical Pathologists</pub><pmid>2547309</pmid><doi>10.1093/ajcp/92.2.222</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9173 |
| ispartof | American journal of clinical pathology, 1989-08, Vol.92 (2), p.222-228 |
| issn | 0002-9173 1943-7722 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79137471 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Acquired Immunodeficiency Syndrome - genetics Adult AIDS/HIV Biological and medical sciences DNA, Viral - genetics Epstein-Barr virus Gene Rearrangement Herpesvirus 4, Human - genetics Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunoglobulin Heavy Chains - genetics Immunoglobulin kappa-Chains - genetics Immunoglobulin lambda-Chains - genetics Immunoglobulin M - genetics Immunopathology Lymphoma, Non-Hodgkin - genetics Lymphoma, Non-Hodgkin - microbiology Male Medical sciences Multiple Myeloma - genetics Multiple Myeloma - microbiology |
| title | Plasma cell malignancy in the acquired immune deficiency syndrome: association with Epstein-Barr virus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T17%3A48%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20cell%20malignancy%20in%20the%20acquired%20immune%20deficiency%20syndrome:%20association%20with%20Epstein-Barr%20virus&rft.jtitle=American%20journal%20of%20clinical%20pathology&rft.au=VOELKERDING,%20K.%20V&rft.date=1989-08-01&rft.volume=92&rft.issue=2&rft.spage=222&rft.epage=228&rft.pages=222-228&rft.issn=0002-9173&rft.eissn=1943-7722&rft.coden=AJCPAI&rft_id=info:doi/10.1093/ajcp/92.2.222&rft_dat=%3Cproquest_cross%3E79137471%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15330371&rft_id=info:pmid/2547309&rfr_iscdi=true |