Proton magnetic resonance spectroscopy can differentiate Alzheimer's disease from normal aging
In order to evaluate the pattern of proton magnetic resonance spectroscopy ( 1H-MRS) in the gray and white matter of patients with Alzheimer's disease (AD) and healthy controls, a cross-sectional study was carried out on 13 consecutive AD patients and 7 healthy older subjects who were referred...
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| Veröffentlicht in: | Mechanisms of ageing and development 1997-07, Vol.97 (1), p.9-14 |
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| container_title | Mechanisms of ageing and development |
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| creator | Parnetti, Lucilla Tarducci, Roberto Presciutti, Otello Lowenthal, David T Pippi, Margherita Palumbo, Barbara Gobbi, Gianni Pelliccioli, Gian Piero Senin, Umberto |
| description | In order to evaluate the pattern of proton magnetic resonance spectroscopy (
1H-MRS) in the gray and white matter of patients with Alzheimer's disease (AD) and healthy controls, a cross-sectional study was carried out on 13 consecutive AD patients and 7 healthy older subjects who were referred to the Day-Hospital for diagnostic assessment. All examinations were performed on a 1.5 Tesla whole-body scanner. Volumes of interest were selected in both the gray (temporal region) and the white (frontal region) matter.
N-acetyl group, total creatine, total choline and myo-inositol were quantified referring the metabolite peak area to the unsuppressed water peak area acquired under the same conditions, and the ratio was expressed in arbitrary units. A significant decrease in
N-acetyl–aspartate (NAA) in both gray and white matter and an increase in myo-inositol (mI) in gray matter of AD patients were observed. The gray matter NAA/mI ratio clearly separated the two groups. White matter mI was significantly associated with severity and duration of dementia. No association with age was documented. It can be concluded that in vivo
1H-MRS can contribute to the knowledge of pathophysiology of AD, giving neurochemical details of both gray and white matter. In particular, the gray matter NAA/mI ratio seems to be able to differentiate normal cerebral aging from Alzheimer's disease. |
| doi_str_mv | 10.1016/S0047-6374(97)01877-0 |
| format | Article |
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1H-MRS) in the gray and white matter of patients with Alzheimer's disease (AD) and healthy controls, a cross-sectional study was carried out on 13 consecutive AD patients and 7 healthy older subjects who were referred to the Day-Hospital for diagnostic assessment. All examinations were performed on a 1.5 Tesla whole-body scanner. Volumes of interest were selected in both the gray (temporal region) and the white (frontal region) matter.
N-acetyl group, total creatine, total choline and myo-inositol were quantified referring the metabolite peak area to the unsuppressed water peak area acquired under the same conditions, and the ratio was expressed in arbitrary units. A significant decrease in
N-acetyl–aspartate (NAA) in both gray and white matter and an increase in myo-inositol (mI) in gray matter of AD patients were observed. The gray matter NAA/mI ratio clearly separated the two groups. White matter mI was significantly associated with severity and duration of dementia. No association with age was documented. It can be concluded that in vivo
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1H-MRS) in the gray and white matter of patients with Alzheimer's disease (AD) and healthy controls, a cross-sectional study was carried out on 13 consecutive AD patients and 7 healthy older subjects who were referred to the Day-Hospital for diagnostic assessment. All examinations were performed on a 1.5 Tesla whole-body scanner. Volumes of interest were selected in both the gray (temporal region) and the white (frontal region) matter.
N-acetyl group, total creatine, total choline and myo-inositol were quantified referring the metabolite peak area to the unsuppressed water peak area acquired under the same conditions, and the ratio was expressed in arbitrary units. A significant decrease in
N-acetyl–aspartate (NAA) in both gray and white matter and an increase in myo-inositol (mI) in gray matter of AD patients were observed. The gray matter NAA/mI ratio clearly separated the two groups. White matter mI was significantly associated with severity and duration of dementia. No association with age was documented. It can be concluded that in vivo
1H-MRS can contribute to the knowledge of pathophysiology of AD, giving neurochemical details of both gray and white matter. In particular, the gray matter NAA/mI ratio seems to be able to differentiate normal cerebral aging from Alzheimer's disease.</description><subject>1H-MRS</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - pathology</subject><subject>Aging brain</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Case-Control Studies</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myo-inositol</subject><subject>N-acetyl–aspartate</subject><subject>Neurology</subject><subject>Proton magnetic resonance spectroscopy</subject><subject>Protons</subject><subject>Reference Values</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LHDEUhkOx6Kr9CUIuirUXo0kmk48rEdFaECxUbxsymZNtZCbZJrMF--sb3WVvvTqB9znn5DwInVByTgkVFz8J4bIRreRnWn4lVEnZkA9oUR-sEYyKPbTYIQfosJRnQgjlTOyjfc1YSxlboF8_cppTxJNdRpiDwxlKijY6wGUFbs6puLR6wc5GPATvIUOcg50BX43_fkOYIH8pNSlgC2Cf04RjypMdsV2GuDxGH70dC3za1iP0dHvzeH3X3D98-359dd84zunc-EF3vKetHnre9kqBGpjVvO2YV70HZltuFRGik4rU0quBdPWQ3nFPiKvgETrdzF3l9GcNZTZTKA7G0UZI62Kkpq1QSlew24CuXlYyeLPKYbL5xVBiXr2aN6_mVZrR0rx5NaT2nWwXrPsJhl3XVmTNP29zW5wdfa4KQ9lhTFKmtKjY5QaDKuNvgGyKC1BtDyFX22ZI4Z2P_Af5h5UD</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>Parnetti, Lucilla</creator><creator>Tarducci, Roberto</creator><creator>Presciutti, Otello</creator><creator>Lowenthal, David T</creator><creator>Pippi, Margherita</creator><creator>Palumbo, Barbara</creator><creator>Gobbi, Gianni</creator><creator>Pelliccioli, Gian Piero</creator><creator>Senin, Umberto</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970701</creationdate><title>Proton magnetic resonance spectroscopy can differentiate Alzheimer's disease from normal aging</title><author>Parnetti, Lucilla ; Tarducci, Roberto ; Presciutti, Otello ; Lowenthal, David T ; Pippi, Margherita ; Palumbo, Barbara ; Gobbi, Gianni ; Pelliccioli, Gian Piero ; Senin, Umberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-fd954b139db43b88e8d2a94352f8bfe2a34a80665780066b8d05426bc4f00c943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>1H-MRS</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - pathology</topic><topic>Aging brain</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Case-Control Studies</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. 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Prion diseases</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myo-inositol</topic><topic>N-acetyl–aspartate</topic><topic>Neurology</topic><topic>Proton magnetic resonance spectroscopy</topic><topic>Protons</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parnetti, Lucilla</creatorcontrib><creatorcontrib>Tarducci, Roberto</creatorcontrib><creatorcontrib>Presciutti, Otello</creatorcontrib><creatorcontrib>Lowenthal, David T</creatorcontrib><creatorcontrib>Pippi, Margherita</creatorcontrib><creatorcontrib>Palumbo, Barbara</creatorcontrib><creatorcontrib>Gobbi, Gianni</creatorcontrib><creatorcontrib>Pelliccioli, Gian Piero</creatorcontrib><creatorcontrib>Senin, Umberto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parnetti, Lucilla</au><au>Tarducci, Roberto</au><au>Presciutti, Otello</au><au>Lowenthal, David T</au><au>Pippi, Margherita</au><au>Palumbo, Barbara</au><au>Gobbi, Gianni</au><au>Pelliccioli, Gian Piero</au><au>Senin, Umberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proton magnetic resonance spectroscopy can differentiate Alzheimer's disease from normal aging</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>1997-07-01</date><risdate>1997</risdate><volume>97</volume><issue>1</issue><spage>9</spage><epage>14</epage><pages>9-14</pages><issn>0047-6374</issn><eissn>1872-6216</eissn><coden>MAGDA3</coden><abstract>In order to evaluate the pattern of proton magnetic resonance spectroscopy (
1H-MRS) in the gray and white matter of patients with Alzheimer's disease (AD) and healthy controls, a cross-sectional study was carried out on 13 consecutive AD patients and 7 healthy older subjects who were referred to the Day-Hospital for diagnostic assessment. All examinations were performed on a 1.5 Tesla whole-body scanner. Volumes of interest were selected in both the gray (temporal region) and the white (frontal region) matter.
N-acetyl group, total creatine, total choline and myo-inositol were quantified referring the metabolite peak area to the unsuppressed water peak area acquired under the same conditions, and the ratio was expressed in arbitrary units. A significant decrease in
N-acetyl–aspartate (NAA) in both gray and white matter and an increase in myo-inositol (mI) in gray matter of AD patients were observed. The gray matter NAA/mI ratio clearly separated the two groups. White matter mI was significantly associated with severity and duration of dementia. No association with age was documented. It can be concluded that in vivo
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| subjects | 1H-MRS Aged Aged, 80 and over Aging - pathology Aging brain Alzheimer Disease - diagnosis Alzheimer's disease Biological and medical sciences Brain - pathology Case-Control Studies Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diagnosis, Differential Female Humans Magnetic Resonance Spectroscopy - methods Male Medical sciences Middle Aged Myo-inositol N-acetyl–aspartate Neurology Proton magnetic resonance spectroscopy Protons Reference Values |
| title | Proton magnetic resonance spectroscopy can differentiate Alzheimer's disease from normal aging |
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