Maturation induction in freshly isolated human myeloid leukemic cells, 1.25 (OH) 2 vitamin D3 being the most potent inducer

From ten consecutive patients with acute myeloid leukemia leukemic cells were isolated and cultured with and without 10 −6, 10 −7 and 10 −8M 1.25(OH) 2D3 (vit D3), retinoic acid (RA) cytosine-arabinoside (ARA-C) and 1.0, 1.25 and 1.5% dimethyl sulfoxide (DMSO). Maturation was measured with a compreh...

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