The Response to Calorie Restriction in Mammals Shows Features Also Common to Hibernation: A Cross-Adaptation Hypothesis
The marked elevation in hepatic carbamyl phosphate synthetase I (CPSI) in calorie-restricted mice, and the changes in erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and in hemoglobin oxygen affinity in calorie-restricted and hypoxic humans living in Biosphere 2 suggest similarities between physiologic...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 1997-07, Vol.52A (4), p.B179-B183 |
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| container_end_page | B183 |
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| container_issue | 4 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
| container_volume | 52A |
| creator | Walford, Roy L. Spindler, Stephen R. |
| description | The marked elevation in hepatic carbamyl phosphate synthetase I (CPSI) in calorie-restricted mice, and the changes in erythrocyte 2,3-diphosphoglycerate (2,3-DPG) and in hemoglobin oxygen affinity in calorie-restricted and hypoxic humans living in Biosphere 2 suggest similarities between physiologic events in calorie restriction and hibernation. Other data from the literature strengthen this comparison. Accordingly, we hypothesize that the response to the calorie restriction regime as studied by gerontologists, rather than being a laboratory artifact, is part of a spectrum of responses to food deprivation which have adaptive value in the wild, and whose triggering mechanism may primarily involve the neuroendocrine system. |
| doi_str_mv | 10.1093/gerona/52A.4.B179 |
| format | Article |
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Other data from the literature strengthen this comparison. Accordingly, we hypothesize that the response to the calorie restriction regime as studied by gerontologists, rather than being a laboratory artifact, is part of a spectrum of responses to food deprivation which have adaptive value in the wild, and whose triggering mechanism may primarily involve the neuroendocrine system.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/52A.4.B179</identifier><identifier>PMID: 9224421</identifier><language>eng</language><publisher>United States: The Gerontological Society of America</publisher><subject>Adaptation, Physiological ; Animals ; Energy Intake ; Gerontology ; Hibernation - physiology ; Humans ; Malnutrition ; Mammals ; Mammals - physiology ; Models, Biological ; Space life sciences</subject><ispartof>The journals of gerontology. 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| ispartof | The journals of gerontology. Series A, Biological sciences and medical sciences, 1997-07, Vol.52A (4), p.B179-B183 |
| issn | 1079-5006 1758-535X |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adaptation, Physiological Animals Energy Intake Gerontology Hibernation - physiology Humans Malnutrition Mammals Mammals - physiology Models, Biological Space life sciences |
| title | The Response to Calorie Restriction in Mammals Shows Features Also Common to Hibernation: A Cross-Adaptation Hypothesis |
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