Mutations in the M4 domain of the Torpedo californica nicotinic acetylcholine receptor alter channel opening and closing

We studied the functional effects of single amino acid substitutions in the postulated M4 transmembrane domains of Torpedo californica nicotinic acetylcholine receptors (nAChRs) expressed in Xenopus oocytes at the single-channel level. At low ACh concentrations and cold temperatures, the replacement...

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Veröffentlicht in:	The Journal of membrane biology 1997-07, Vol.158 (1), p.17-30
Hauptverfasser:	Ortiz-Miranda, S I, Lasalde, J A, Pappone, P A, McNamee, M G
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Ion Channel Gating - physiology Mutation Protein Structure, Tertiary Receptors, Nicotinic - chemistry Receptors, Nicotinic - genetics Sequence Homology, Amino Acid Torpedo
Online-Zugang:	Volltext
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