T lymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians

It is generally assumed that T cell proliferation is impaired in aged individuals. We report data on the proliferative capability of peripheral blood mononuclear cells (PBMC) and T lymphocytes from 40 healthy people of different ages, (19–107 years), including 14 centenarians, to defined mitogenic s...

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Veröffentlicht in:	Mechanisms of ageing and development 1997-06, Vol.96 (1-3), p.127-136
Hauptverfasser:	Sansoni, Paolo, Fagnoni, Francesco, Vescovini, Rosanna, Mazzola, Marco, Brianti, Vincenzo, Bologna, Giovanni, Nigro, Enrica, Lavagetto, Giampaolo, Cossarizza, Andrea, Monti, Daniela, Franceschi, Claudio, Passeri, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Aging - immunology Biological and medical sciences CD28 CD28 Antigens - immunology Cell Division - drug effects Cell Division - immunology Cell Separation Centenarians Development. Metamorphosis. Moult. Ageing Female Fundamental and applied biological sciences. Psychology Humans Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Male Middle Aged Mitogens - pharmacology Proliferation Reference Values T cells T-Lymphocytes - cytology T-Lymphocytes - drug effects Vertebrates: anatomy and physiology, studies on body, several organs or systems
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