Corpus callosum involvement as a prognostic factor for patients with high-grade astrocytoma
To evaluate corpus callosum involvement as a prognostic factor for patients with high-grade astrocytoma. From 1986 through 1994, 141 adult patients with Karnofsky performance status (KPS) > or = 40 underwent primary treatment for anaplastic astrocytoma (AA) or glioblastoma multiforme (GBM) at the...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 1997-04, Vol.38 (1), p.27-30 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Stelzer, Keith J. Sauvé, Kristen I. Spence, Alexander M. Griffin, Thomas W. Berger, Mitchel S. |
| description | To evaluate corpus callosum involvement as a prognostic factor for patients with high-grade astrocytoma.
From 1986 through 1994, 141 adult patients with Karnofsky performance status (KPS) > or = 40 underwent primary treatment for anaplastic astrocytoma (AA) or glioblastoma multiforme (GBM) at the University of Washington Medical Center. Preoperative magnetic resonance imaging and/or computed tomography to assess corpus callosum involvement was available for 105 of these patients. Corpus callosum involvement was evaluated as a prognostic factor for survival using recursive partitioning analysis and multivariate analysis with a Cox proportional hazards model.
For the 105 patients evaluable for corpus callosum involvement, the median and 2-year survival were 59 weeks and 28%, respectively. On multivariate analysis, the only independent prognostic factors were KPS (p = 0.0001) and histology (p = 0.042). On recursive partitioning analysis, the first significant split occurred at KPS < 70 vs. KPS > or = 70. Patients with KPS > or = 70 were split by age (< 50 years vs. > or = 50 years), with those younger than 50 years further split by absence or presence of corpus callosum involvement. Among patients with KPS > or = 70 and age < 50 years, median survival was 57 weeks if the corpus callosum was involved (35% 2-year survival) and 105 weeks if the corpus callosum was not involved (56% 2-year survival).
Corpus callosum involvement based on preoperative imaging is an unfavorable prognostic factor for survival among the subgroup of young, good-performance-status patients with high-grade astrocytoma. |
| doi_str_mv | 10.1016/S0360-3016(96)00632-3 |
| format | Article |
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From 1986 through 1994, 141 adult patients with Karnofsky performance status (KPS) > or = 40 underwent primary treatment for anaplastic astrocytoma (AA) or glioblastoma multiforme (GBM) at the University of Washington Medical Center. Preoperative magnetic resonance imaging and/or computed tomography to assess corpus callosum involvement was available for 105 of these patients. Corpus callosum involvement was evaluated as a prognostic factor for survival using recursive partitioning analysis and multivariate analysis with a Cox proportional hazards model.
For the 105 patients evaluable for corpus callosum involvement, the median and 2-year survival were 59 weeks and 28%, respectively. On multivariate analysis, the only independent prognostic factors were KPS (p = 0.0001) and histology (p = 0.042). On recursive partitioning analysis, the first significant split occurred at KPS < 70 vs. KPS > or = 70. Patients with KPS > or = 70 were split by age (< 50 years vs. > or = 50 years), with those younger than 50 years further split by absence or presence of corpus callosum involvement. Among patients with KPS > or = 70 and age < 50 years, median survival was 57 weeks if the corpus callosum was involved (35% 2-year survival) and 105 weeks if the corpus callosum was not involved (56% 2-year survival).
Corpus callosum involvement based on preoperative imaging is an unfavorable prognostic factor for survival among the subgroup of young, good-performance-status patients with high-grade astrocytoma.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/S0360-3016(96)00632-3</identifier><identifier>PMID: 9212000</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Anaplastic astrocytoma ; Biological and medical sciences ; Brain Neoplasms - pathology ; Corpus callosum ; Corpus Callosum - pathology ; Glioblastoma - pathology ; Glioblastoma multiforme ; Humans ; Karnofsky Performance Status ; Medical sciences ; Middle Aged ; Neurology ; Prognosis ; Proportional Hazards Models ; Recursive partitioning analysis ; Tumors of the nervous system. Phacomatoses</subject><ispartof>International journal of radiation oncology, biology, physics, 1997-04, Vol.38 (1), p.27-30</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-5d9356cd36c426996d6f810a59ca9fa62824c52e5ca5ac49606291e1e0e8bf093</citedby><cites>FETCH-LOGICAL-c389t-5d9356cd36c426996d6f810a59ca9fa62824c52e5ca5ac49606291e1e0e8bf093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0360-3016(96)00632-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2742067$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9212000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stelzer, Keith J.</creatorcontrib><creatorcontrib>Sauvé, Kristen I.</creatorcontrib><creatorcontrib>Spence, Alexander M.</creatorcontrib><creatorcontrib>Griffin, Thomas W.</creatorcontrib><creatorcontrib>Berger, Mitchel S.</creatorcontrib><title>Corpus callosum involvement as a prognostic factor for patients with high-grade astrocytoma</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>To evaluate corpus callosum involvement as a prognostic factor for patients with high-grade astrocytoma.
From 1986 through 1994, 141 adult patients with Karnofsky performance status (KPS) > or = 40 underwent primary treatment for anaplastic astrocytoma (AA) or glioblastoma multiforme (GBM) at the University of Washington Medical Center. Preoperative magnetic resonance imaging and/or computed tomography to assess corpus callosum involvement was available for 105 of these patients. Corpus callosum involvement was evaluated as a prognostic factor for survival using recursive partitioning analysis and multivariate analysis with a Cox proportional hazards model.
For the 105 patients evaluable for corpus callosum involvement, the median and 2-year survival were 59 weeks and 28%, respectively. On multivariate analysis, the only independent prognostic factors were KPS (p = 0.0001) and histology (p = 0.042). On recursive partitioning analysis, the first significant split occurred at KPS < 70 vs. KPS > or = 70. Patients with KPS > or = 70 were split by age (< 50 years vs. > or = 50 years), with those younger than 50 years further split by absence or presence of corpus callosum involvement. Among patients with KPS > or = 70 and age < 50 years, median survival was 57 weeks if the corpus callosum was involved (35% 2-year survival) and 105 weeks if the corpus callosum was not involved (56% 2-year survival).
Corpus callosum involvement based on preoperative imaging is an unfavorable prognostic factor for survival among the subgroup of young, good-performance-status patients with high-grade astrocytoma.</description><subject>Anaplastic astrocytoma</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - pathology</subject><subject>Corpus callosum</subject><subject>Corpus Callosum - pathology</subject><subject>Glioblastoma - pathology</subject><subject>Glioblastoma multiforme</subject><subject>Humans</subject><subject>Karnofsky Performance Status</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Recursive partitioning analysis</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpSLdJf0JAh1KSg1N9WLJ1KmFJ2kAgh7QQ6EFM5PGuim1tJXlD_n2V7LLXHoQk5nlnhoeQM84uOeP66wOTmlWyPM-NvmBMS1HJd2TB28ZUUqnH92RxQD6Qjyn9YYxx3tTH5NgILspvQX4vQ9zMiToYhpDmkfppG4YtjjhlCokC3cSwmkLK3tEeXA6R9uVsIPuCJPrs85qu_WpdrSJ0WDI5BveSwwin5KiHIeGn_X1Cft1c_1z-qO7uv98ur-4qJ1uTK9UZqbTrpHa10MboTvctZ6CMA9ODFq2onRKoHChwtdFMC8ORI8P2qWdGnpAvu75l1b8zpmxHnxwOA0wY5mQbw2UtpSig2oEuhpQi9nYT_QjxxXJmX6XaN6n21Zg12r5JtbLkzvYD5qcRu0Nqb7HUP-_rkIrIPsLkfDpgoqkF003Bvu0wLDK2HqNNrkh02PmILtsu-P8s8g8iCZP_</recordid><startdate>19970401</startdate><enddate>19970401</enddate><creator>Stelzer, Keith J.</creator><creator>Sauvé, Kristen I.</creator><creator>Spence, Alexander M.</creator><creator>Griffin, Thomas W.</creator><creator>Berger, Mitchel S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970401</creationdate><title>Corpus callosum involvement as a prognostic factor for patients with high-grade astrocytoma</title><author>Stelzer, Keith J. ; Sauvé, Kristen I. ; Spence, Alexander M. ; Griffin, Thomas W. ; Berger, Mitchel S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-5d9356cd36c426996d6f810a59ca9fa62824c52e5ca5ac49606291e1e0e8bf093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Anaplastic astrocytoma</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - pathology</topic><topic>Corpus callosum</topic><topic>Corpus Callosum - pathology</topic><topic>Glioblastoma - pathology</topic><topic>Glioblastoma multiforme</topic><topic>Humans</topic><topic>Karnofsky Performance Status</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Recursive partitioning analysis</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stelzer, Keith J.</creatorcontrib><creatorcontrib>Sauvé, Kristen I.</creatorcontrib><creatorcontrib>Spence, Alexander M.</creatorcontrib><creatorcontrib>Griffin, Thomas W.</creatorcontrib><creatorcontrib>Berger, Mitchel S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stelzer, Keith J.</au><au>Sauvé, Kristen I.</au><au>Spence, Alexander M.</au><au>Griffin, Thomas W.</au><au>Berger, Mitchel S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Corpus callosum involvement as a prognostic factor for patients with high-grade astrocytoma</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>1997-04-01</date><risdate>1997</risdate><volume>38</volume><issue>1</issue><spage>27</spage><epage>30</epage><pages>27-30</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>To evaluate corpus callosum involvement as a prognostic factor for patients with high-grade astrocytoma.
From 1986 through 1994, 141 adult patients with Karnofsky performance status (KPS) > or = 40 underwent primary treatment for anaplastic astrocytoma (AA) or glioblastoma multiforme (GBM) at the University of Washington Medical Center. Preoperative magnetic resonance imaging and/or computed tomography to assess corpus callosum involvement was available for 105 of these patients. Corpus callosum involvement was evaluated as a prognostic factor for survival using recursive partitioning analysis and multivariate analysis with a Cox proportional hazards model.
For the 105 patients evaluable for corpus callosum involvement, the median and 2-year survival were 59 weeks and 28%, respectively. On multivariate analysis, the only independent prognostic factors were KPS (p = 0.0001) and histology (p = 0.042). On recursive partitioning analysis, the first significant split occurred at KPS < 70 vs. KPS > or = 70. Patients with KPS > or = 70 were split by age (< 50 years vs. > or = 50 years), with those younger than 50 years further split by absence or presence of corpus callosum involvement. Among patients with KPS > or = 70 and age < 50 years, median survival was 57 weeks if the corpus callosum was involved (35% 2-year survival) and 105 weeks if the corpus callosum was not involved (56% 2-year survival).
Corpus callosum involvement based on preoperative imaging is an unfavorable prognostic factor for survival among the subgroup of young, good-performance-status patients with high-grade astrocytoma.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9212000</pmid><doi>10.1016/S0360-3016(96)00632-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | International journal of radiation oncology, biology, physics, 1997-04, Vol.38 (1), p.27-30 |
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| subjects | Anaplastic astrocytoma Biological and medical sciences Brain Neoplasms - pathology Corpus callosum Corpus Callosum - pathology Glioblastoma - pathology Glioblastoma multiforme Humans Karnofsky Performance Status Medical sciences Middle Aged Neurology Prognosis Proportional Hazards Models Recursive partitioning analysis Tumors of the nervous system. Phacomatoses |
| title | Corpus callosum involvement as a prognostic factor for patients with high-grade astrocytoma |
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