Flunarizine, an anti-migraine agent, impairs nitroxidergic nerve function in cerebral arteries

Flunarizine is an anti-migraine agent that blocks the Ca 2+ entry across cell membrane. In order to obtain a clue of mechanisms underlying the migraine headache, modifications by flunarizine of the response to nitric oxide (NO), a cerebral vasodilator and algogenic agent, derived from perivascular n...

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Veröffentlicht in:	European journal of pharmacology 1997-06, Vol.329 (1), p.49-53
Hauptverfasser:	Ayajiki, Kazuhide, Okamura, Tomio, Toda, Noboru
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Biological and medical sciences Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Cerebral Arteries - drug effects Cerebral Arteries - innervation Cerebral Arteries - metabolism Dogs Electric Stimulation Female Flunarizine Flunarizine - pharmacology Flunarizine - therapeutic use In Vitro Techniques Male Medical sciences Migraine Migraine Disorders - drug therapy Neuropharmacology Nicotine - pharmacology Nitric oxide (NO) Nitric Oxide - antagonists & inhibitors Nitric Oxide - physiology Nitroprusside - pharmacology Pharmacology. Drug treatments Vasodilator nerve
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