Three apparent receptor subtypes for the endothelin/sarafotoxin family

Competition binding experiments performed with 125I-sarafotoxin (SRTX)-b and SRTX-b, SRTX-c and endothelin (ET-1 and ET-3) using homogenates of rat right and left atria, aorta, uterus, cerebellum and caudate putamen indicated heterogeneity of the ET/SRTX receptor. The evidence pointed to the existen...

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Veröffentlicht in:	FEBS letters 1989-08, Vol.253 (1), p.199-202
Hauptverfasser:	Kloog, Y., Bousso-Mittler, D., Bdolah, A., Sokolovsky, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals aorta Aorta - metabolism Binding, Competitive Biological and medical sciences Caudate Nucleus - metabolism Cell receptors Cell structures and functions Cerebellum - metabolism E-Sα, a high-affinity ET-1/SRTX-b subtype E-Sβ, a high-affinity SRTX-c subtype E-Sγ, subtype that binds all of the peptides under investigation with high affinity Endothelin Endothelins ET, endothelin Fundamental and applied biological sciences. Psychology heart Heart Atria - metabolism In Vitro Techniques Miscellaneous Molecular and cellular biology Peptides - metabolism Rat, Brain, Aorta, Heart, Uterus Rats Receptor subtype Receptors, Cell Surface - classification Receptors, Cell Surface - metabolism Receptors, Endothelin Sarafotoxin SRTX, sarafotoxin uterus Viper Venoms - metabolism
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