Analytical study of three-compartment pharmacokinetic models: concentration, area under curves, mean residence time
The analytical expression for the drug concentration in each of the three compartments of a pharmacokinetics model, following any type of administration, is obtained from the transfer or elimination coefficients alone, without numerical approximation. Important applications of this result are the fi...
Gespeichert in:
| Veröffentlicht in: | Journal of biomedical engineering 1989-07, Vol.11 (4), p.345-351 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 351 |
|---|---|
| container_issue | 4 |
| container_start_page | 345 |
| container_title | Journal of biomedical engineering |
| container_volume | 11 |
| creator | Plusquellec, Y. |
| description | The analytical expression for the drug concentration in each of the three compartments of a pharmacokinetics model, following any type of administration, is obtained from the transfer or elimination coefficients alone, without numerical approximation. Important applications of this result are the fitting of experimental data and the calculation of the areas under concentration curves or of the mean residence time of the drug in a given compartment or in the system as a whole. |
| doi_str_mv | 10.1016/0141-5425(89)90071-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79132707</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>014154258990071X</els_id><sourcerecordid>79132707</sourcerecordid><originalsourceid>FETCH-LOGICAL-c302t-77961dca17ad0a057da3320e0d1fb97e5b68814eabbffaf5b4e7cb5f5773e4bb3</originalsourceid><addsrcrecordid>eNp9kE1rFTEUhrNQaq3-A4VsFIWOJvOVmS6EUloVCm4UugsnyQmNTpJrkincf2_Ge6k7V4HzPufN4SHkFWcfOOPjR8Z73gx9O7yb5vczY4I3d0_I6eP4GXme80_G-knw8YSctCOfxTyeknwZYNkXp2GhuaxmT6Ol5T4hNjr6HaTiMRS6u4fkQcdfLmCFqY8Gl3xBdQy65gmKi-GcQkKgazCYqF7TA-Zz6hECTZidwYrS4jy-IE8tLBlfHt8z8uPm-vvVl-b22-evV5e3je5YWxpRD-RGAxdgGLBBGOi6liEz3KpZ4KDGaeI9glLWgh1Uj0KrwQ5CdNgr1Z2Rt4feXYq_V8xFepc1LgsEjGuWYuZdK5ioYH8AdYo5J7Ryl5yHtJecyc2v3ETKTaScZvnXr7yra6-P_avyaB6XjnJr_uaYQ65-bYKgXf7XPQvOeb99_-nAVaX44DDJrN1my7iEukgT3f8P-QNwtpwm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79132707</pqid></control><display><type>article</type><title>Analytical study of three-compartment pharmacokinetic models: concentration, area under curves, mean residence time</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Plusquellec, Y.</creator><creatorcontrib>Plusquellec, Y.</creatorcontrib><description>The analytical expression for the drug concentration in each of the three compartments of a pharmacokinetics model, following any type of administration, is obtained from the transfer or elimination coefficients alone, without numerical approximation. Important applications of this result are the fitting of experimental data and the calculation of the areas under concentration curves or of the mean residence time of the drug in a given compartment or in the system as a whole.</description><identifier>ISSN: 0141-5425</identifier><identifier>DOI: 10.1016/0141-5425(89)90071-X</identifier><identifier>PMID: 2619796</identifier><identifier>CODEN: JBIEDR</identifier><language>eng</language><publisher>Oxford: Elsevier Inc</publisher><subject>area under curves (AUC) ; Biological and medical sciences ; compartment model ; concentration ; General pharmacology ; Humans ; Mathematics ; mean residence time (MRT) ; Medical sciences ; Models, Biological ; Pharmacokinetics ; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions ; Pharmacology. Drug treatments ; Time Factors</subject><ispartof>Journal of biomedical engineering, 1989-07, Vol.11 (4), p.345-351</ispartof><rights>1989</rights><rights>1991 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c302t-77961dca17ad0a057da3320e0d1fb97e5b68814eabbffaf5b4e7cb5f5773e4bb3</citedby><cites>FETCH-LOGICAL-c302t-77961dca17ad0a057da3320e0d1fb97e5b68814eabbffaf5b4e7cb5f5773e4bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19711147$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2619796$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plusquellec, Y.</creatorcontrib><title>Analytical study of three-compartment pharmacokinetic models: concentration, area under curves, mean residence time</title><title>Journal of biomedical engineering</title><addtitle>J Biomed Eng</addtitle><description>The analytical expression for the drug concentration in each of the three compartments of a pharmacokinetics model, following any type of administration, is obtained from the transfer or elimination coefficients alone, without numerical approximation. Important applications of this result are the fitting of experimental data and the calculation of the areas under concentration curves or of the mean residence time of the drug in a given compartment or in the system as a whole.</description><subject>area under curves (AUC)</subject><subject>Biological and medical sciences</subject><subject>compartment model</subject><subject>concentration</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Mathematics</subject><subject>mean residence time (MRT)</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Pharmacokinetics</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>Time Factors</subject><issn>0141-5425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rFTEUhrNQaq3-A4VsFIWOJvOVmS6EUloVCm4UugsnyQmNTpJrkincf2_Ge6k7V4HzPufN4SHkFWcfOOPjR8Z73gx9O7yb5vczY4I3d0_I6eP4GXme80_G-knw8YSctCOfxTyeknwZYNkXp2GhuaxmT6Ol5T4hNjr6HaTiMRS6u4fkQcdfLmCFqY8Gl3xBdQy65gmKi-GcQkKgazCYqF7TA-Zz6hECTZidwYrS4jy-IE8tLBlfHt8z8uPm-vvVl-b22-evV5e3je5YWxpRD-RGAxdgGLBBGOi6liEz3KpZ4KDGaeI9glLWgh1Uj0KrwQ5CdNgr1Z2Rt4feXYq_V8xFepc1LgsEjGuWYuZdK5ioYH8AdYo5J7Ryl5yHtJecyc2v3ETKTaScZvnXr7yra6-P_avyaB6XjnJr_uaYQ65-bYKgXf7XPQvOeb99_-nAVaX44DDJrN1my7iEukgT3f8P-QNwtpwm</recordid><startdate>198907</startdate><enddate>198907</enddate><creator>Plusquellec, Y.</creator><general>Elsevier Inc</general><general>Butterworth-Heinemann</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198907</creationdate><title>Analytical study of three-compartment pharmacokinetic models: concentration, area under curves, mean residence time</title><author>Plusquellec, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c302t-77961dca17ad0a057da3320e0d1fb97e5b68814eabbffaf5b4e7cb5f5773e4bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>area under curves (AUC)</topic><topic>Biological and medical sciences</topic><topic>compartment model</topic><topic>concentration</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Mathematics</topic><topic>mean residence time (MRT)</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Pharmacokinetics</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Plusquellec, Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical engineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plusquellec, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analytical study of three-compartment pharmacokinetic models: concentration, area under curves, mean residence time</atitle><jtitle>Journal of biomedical engineering</jtitle><addtitle>J Biomed Eng</addtitle><date>1989-07</date><risdate>1989</risdate><volume>11</volume><issue>4</issue><spage>345</spage><epage>351</epage><pages>345-351</pages><issn>0141-5425</issn><coden>JBIEDR</coden><abstract>The analytical expression for the drug concentration in each of the three compartments of a pharmacokinetics model, following any type of administration, is obtained from the transfer or elimination coefficients alone, without numerical approximation. Important applications of this result are the fitting of experimental data and the calculation of the areas under concentration curves or of the mean residence time of the drug in a given compartment or in the system as a whole.</abstract><cop>Oxford</cop><pub>Elsevier Inc</pub><pmid>2619796</pmid><doi>10.1016/0141-5425(89)90071-X</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0141-5425 |
| ispartof | Journal of biomedical engineering, 1989-07, Vol.11 (4), p.345-351 |
| issn | 0141-5425 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79132707 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | area under curves (AUC) Biological and medical sciences compartment model concentration General pharmacology Humans Mathematics mean residence time (MRT) Medical sciences Models, Biological Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Time Factors |
| title | Analytical study of three-compartment pharmacokinetic models: concentration, area under curves, mean residence time |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T07%3A28%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analytical%20study%20of%20three-compartment%20pharmacokinetic%20models:%20concentration,%20area%20under%20curves,%20mean%20residence%20time&rft.jtitle=Journal%20of%20biomedical%20engineering&rft.au=Plusquellec,%20Y.&rft.date=1989-07&rft.volume=11&rft.issue=4&rft.spage=345&rft.epage=351&rft.pages=345-351&rft.issn=0141-5425&rft.coden=JBIEDR&rft_id=info:doi/10.1016/0141-5425(89)90071-X&rft_dat=%3Cproquest_cross%3E79132707%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79132707&rft_id=info:pmid/2619796&rft_els_id=014154258990071X&rfr_iscdi=true |