Adenosine as an Antiarrhythmic Agent
Adenosine produces acute inhibition of sinus node and atrioventricular (AV) nodal function. This profound but short lived electrophysiologic effect makes adenosine a suitable agent for treating supraventricular tachycardias (SVT) that incorporate the sinus node or AV node as part of the arrhythmia c...
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| Veröffentlicht in: | The American journal of cardiology 1997-06, Vol.79 (12), p.30-37 |
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| container_title | The American journal of cardiology |
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| creator | Wilbur, Sabrina L Marchlinski, Francis E |
| description | Adenosine produces acute inhibition of sinus node and atrioventricular (AV) nodal function. This profound but short lived electrophysiologic effect makes adenosine a suitable agent for treating supraventricular tachycardias (SVT) that incorporate the sinus node or AV node as part of the arrhythmia circuit, or for unmasking atrial tachyarrhythmias or ventricular pre-excitation. Its antiadrenergic properties also make it an effective agent for use with some unique atrial and ventricular tachycardias. Appropriate dosing and rapid bolusing with intravenous administration is required. Recognition of infrequent proarrhythmic risks and potential drug interactions with xanthine derivatives and dipyridamole should maximize its safe and effective use. This review will highlight adenosine's mechanism of action, administration, clinical indications, efficacy, and risks when used in tachyarrhythmic management. |
| doi_str_mv | 10.1016/S0002-9149(97)00261-0 |
| format | Article |
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This profound but short lived electrophysiologic effect makes adenosine a suitable agent for treating supraventricular tachycardias (SVT) that incorporate the sinus node or AV node as part of the arrhythmia circuit, or for unmasking atrial tachyarrhythmias or ventricular pre-excitation. Its antiadrenergic properties also make it an effective agent for use with some unique atrial and ventricular tachycardias. Appropriate dosing and rapid bolusing with intravenous administration is required. Recognition of infrequent proarrhythmic risks and potential drug interactions with xanthine derivatives and dipyridamole should maximize its safe and effective use. 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This profound but short lived electrophysiologic effect makes adenosine a suitable agent for treating supraventricular tachycardias (SVT) that incorporate the sinus node or AV node as part of the arrhythmia circuit, or for unmasking atrial tachyarrhythmias or ventricular pre-excitation. Its antiadrenergic properties also make it an effective agent for use with some unique atrial and ventricular tachycardias. Appropriate dosing and rapid bolusing with intravenous administration is required. Recognition of infrequent proarrhythmic risks and potential drug interactions with xanthine derivatives and dipyridamole should maximize its safe and effective use. 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| subjects | Adenosine Adenosine - administration & dosage Adenosine - therapeutic use Anti-Arrhythmia Agents - administration & dosage Anti-Arrhythmia Agents - therapeutic use Antiarrhythmics Antiarythmic agents Arrhythmias, Cardiac - drug therapy Biological and medical sciences Cardiac arrhythmia Cardiovascular system Child Drug dosages Drug therapy Electrocardiography Female Humans Medical sciences Patients Pharmacology. Drug treatments Pregnancy Pregnancy Complications, Cardiovascular - drug therapy Rodents Sinuses Tachycardia, Sinoatrial Nodal Reentry - drug therapy Tachycardia, Ventricular - drug therapy Wolff-Parkinson-White Syndrome - drug therapy |
| title | Adenosine as an Antiarrhythmic Agent |
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