An immunohistochemical study of endogenous estradiol and testosterone in human colo-rectal cancer tissues
An immunohistochemical method (peroxidase antiperoxidase method) was carried out to examine the distribution of endogenous estradiol (E2) and testosterone (Te). One hundred and twenty four (48.2%) of 257 colo-rectal cancer cases, and 36.7% of male cases and 58.4% of female cases revealed E2-immunost...
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| Veröffentlicht in: | Nippon Shokakibyo Gakkai Zasshi 1989, Vol.86(2), pp.200-207 |
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| container_title | Nippon Shokakibyo Gakkai Zasshi |
| container_volume | 86 |
| creator | TAKEDA, Hiroaki YAMAKAWA, Mitsunori SATOH, Toshihiro IMAI, Yutaka TOYONO, Mitsuru TSUKAMOTO, Masaru TAKAHASHI, Tsuneo ISHIKAWA, Makoto |
| description | An immunohistochemical method (peroxidase antiperoxidase method) was carried out to examine the distribution of endogenous estradiol (E2) and testosterone (Te). One hundred and twenty four (48.2%) of 257 colo-rectal cancer cases, and 36.7% of male cases and 58.4% of female cases revealed E2-immunostain. This immunohistochemical reaction for E2 was found more frequently in female patients than in male patients, while Te-immunostain was found in 15 (17.6%) of 85 colo-rectal cancer cases. E2 and Te were demonstrated mainly in the cytoplasms and occasionally in the nuclei of cancer cells. Since E2 or Te-positive cancer cells were mainly distributed in the deeper or invasive portion of tissue sections, it might deserve further investigation to elucidate a certain relationship between cancer growth and endogenous sex-hormones. |
| doi_str_mv | 10.11405/nisshoshi1964.86.200 |
| format | Article |
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One hundred and twenty four (48.2%) of 257 colo-rectal cancer cases, and 36.7% of male cases and 58.4% of female cases revealed E2-immunostain. This immunohistochemical reaction for E2 was found more frequently in female patients than in male patients, while Te-immunostain was found in 15 (17.6%) of 85 colo-rectal cancer cases. E2 and Te were demonstrated mainly in the cytoplasms and occasionally in the nuclei of cancer cells. Since E2 or Te-positive cancer cells were mainly distributed in the deeper or invasive portion of tissue sections, it might deserve further investigation to elucidate a certain relationship between cancer growth and endogenous sex-hormones.</description><identifier>ISSN: 0446-6586</identifier><identifier>EISSN: 1349-7693</identifier><identifier>DOI: 10.11405/nisshoshi1964.86.200</identifier><identifier>PMID: 2666696</identifier><language>jpn</language><publisher>Japan: The Japanese Society of Gastroenterology</publisher><subject>colo-rectal cancer ; Colorectal Neoplasms - analysis ; Colorectal Neoplasms - pathology ; Cytoplasm - analysis ; estradiol ; Estradiol - analysis ; Female ; Humans ; Immunoenzyme Techniques ; immunohistochemistry ; Male ; Neoplasm Invasiveness ; Sex Factors ; sex hormones ; testosterone ; Testosterone - analysis</subject><ispartof>Nippon Shokakibyo Gakkai Zasshi, 1989, Vol.86(2), pp.200-207</ispartof><rights>The Japanese Society of Gastroenterology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2666696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TAKEDA, Hiroaki</creatorcontrib><creatorcontrib>YAMAKAWA, Mitsunori</creatorcontrib><creatorcontrib>SATOH, Toshihiro</creatorcontrib><creatorcontrib>IMAI, Yutaka</creatorcontrib><creatorcontrib>TOYONO, Mitsuru</creatorcontrib><creatorcontrib>TSUKAMOTO, Masaru</creatorcontrib><creatorcontrib>TAKAHASHI, Tsuneo</creatorcontrib><creatorcontrib>ISHIKAWA, Makoto</creatorcontrib><title>An immunohistochemical study of endogenous estradiol and testosterone in human colo-rectal cancer tissues</title><title>Nippon Shokakibyo Gakkai Zasshi</title><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><description>An immunohistochemical method (peroxidase antiperoxidase method) was carried out to examine the distribution of endogenous estradiol (E2) and testosterone (Te). One hundred and twenty four (48.2%) of 257 colo-rectal cancer cases, and 36.7% of male cases and 58.4% of female cases revealed E2-immunostain. This immunohistochemical reaction for E2 was found more frequently in female patients than in male patients, while Te-immunostain was found in 15 (17.6%) of 85 colo-rectal cancer cases. E2 and Te were demonstrated mainly in the cytoplasms and occasionally in the nuclei of cancer cells. Since E2 or Te-positive cancer cells were mainly distributed in the deeper or invasive portion of tissue sections, it might deserve further investigation to elucidate a certain relationship between cancer growth and endogenous sex-hormones.</description><subject>colo-rectal cancer</subject><subject>Colorectal Neoplasms - analysis</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Cytoplasm - analysis</subject><subject>estradiol</subject><subject>Estradiol - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>immunohistochemistry</subject><subject>Male</subject><subject>Neoplasm Invasiveness</subject><subject>Sex Factors</subject><subject>sex hormones</subject><subject>testosterone</subject><subject>Testosterone - analysis</subject><issn>0446-6586</issn><issn>1349-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUctqwzAQFKUlDWk-IaBTb071smwfQ-gjEOilPRtFWscKtpRK8iF_X0FCoXvYZZlh9jEIrShZUypI-eJsjL2PvaWNFOtarhkhd2hOuWiKSjb8Hs2JELKQZS0f0TJGeyCENGVTcz5DMyZzNHKO7MZhO46T872NyeseRqvVgGOazAX7DoMz_gjOTxFDTEEZ6wesnMEptz4mCN4Btg7306gc1n7wRQCdsoZWTkPAKa86QXxCD50aIixvdYG-316_th_F_vN9t93sixMTIhVCUl5VVIHuSg6SlUCVaRhlYIDUtakNOxjeaaaF0arjlRCUqwrKkhgKB8UX6Pmqew7-J89N7WijhmFQDvIVbdVQVknJMnF1I06HEUx7DnZU4dLefpPx3RU_xaSO8IerkKweoP1nQVvLll1TduKPo3sVWnD8F5Wnh1Y</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>TAKEDA, Hiroaki</creator><creator>YAMAKAWA, Mitsunori</creator><creator>SATOH, Toshihiro</creator><creator>IMAI, Yutaka</creator><creator>TOYONO, Mitsuru</creator><creator>TSUKAMOTO, Masaru</creator><creator>TAKAHASHI, Tsuneo</creator><creator>ISHIKAWA, Makoto</creator><general>The Japanese Society of Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>An immunohistochemical study of endogenous estradiol and testosterone in human colo-rectal cancer tissues</title><author>TAKEDA, Hiroaki ; YAMAKAWA, Mitsunori ; SATOH, Toshihiro ; IMAI, Yutaka ; TOYONO, Mitsuru ; TSUKAMOTO, Masaru ; TAKAHASHI, Tsuneo ; ISHIKAWA, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j244t-4613771aecf53e625e1ad9212ede088d8d2bd3fc2c4dcaf374413a7e550d1eba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1989</creationdate><topic>colo-rectal cancer</topic><topic>Colorectal Neoplasms - analysis</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Cytoplasm - analysis</topic><topic>estradiol</topic><topic>Estradiol - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>immunohistochemistry</topic><topic>Male</topic><topic>Neoplasm Invasiveness</topic><topic>Sex Factors</topic><topic>sex hormones</topic><topic>testosterone</topic><topic>Testosterone - analysis</topic><toplevel>online_resources</toplevel><creatorcontrib>TAKEDA, Hiroaki</creatorcontrib><creatorcontrib>YAMAKAWA, Mitsunori</creatorcontrib><creatorcontrib>SATOH, Toshihiro</creatorcontrib><creatorcontrib>IMAI, Yutaka</creatorcontrib><creatorcontrib>TOYONO, Mitsuru</creatorcontrib><creatorcontrib>TSUKAMOTO, Masaru</creatorcontrib><creatorcontrib>TAKAHASHI, Tsuneo</creatorcontrib><creatorcontrib>ISHIKAWA, Makoto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TAKEDA, Hiroaki</au><au>YAMAKAWA, Mitsunori</au><au>SATOH, Toshihiro</au><au>IMAI, Yutaka</au><au>TOYONO, Mitsuru</au><au>TSUKAMOTO, Masaru</au><au>TAKAHASHI, Tsuneo</au><au>ISHIKAWA, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An immunohistochemical study of endogenous estradiol and testosterone in human colo-rectal cancer tissues</atitle><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><date>1989</date><risdate>1989</risdate><volume>86</volume><issue>2</issue><spage>200</spage><epage>207</epage><pages>200-207</pages><issn>0446-6586</issn><eissn>1349-7693</eissn><abstract>An immunohistochemical method (peroxidase antiperoxidase method) was carried out to examine the distribution of endogenous estradiol (E2) and testosterone (Te). One hundred and twenty four (48.2%) of 257 colo-rectal cancer cases, and 36.7% of male cases and 58.4% of female cases revealed E2-immunostain. This immunohistochemical reaction for E2 was found more frequently in female patients than in male patients, while Te-immunostain was found in 15 (17.6%) of 85 colo-rectal cancer cases. E2 and Te were demonstrated mainly in the cytoplasms and occasionally in the nuclei of cancer cells. Since E2 or Te-positive cancer cells were mainly distributed in the deeper or invasive portion of tissue sections, it might deserve further investigation to elucidate a certain relationship between cancer growth and endogenous sex-hormones.</abstract><cop>Japan</cop><pub>The Japanese Society of Gastroenterology</pub><pmid>2666696</pmid><doi>10.11405/nisshoshi1964.86.200</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0446-6586 |
| ispartof | Nippon Shokakibyo Gakkai Zasshi, 1989, Vol.86(2), pp.200-207 |
| issn | 0446-6586 1349-7693 |
| language | jpn |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | colo-rectal cancer Colorectal Neoplasms - analysis Colorectal Neoplasms - pathology Cytoplasm - analysis estradiol Estradiol - analysis Female Humans Immunoenzyme Techniques immunohistochemistry Male Neoplasm Invasiveness Sex Factors sex hormones testosterone Testosterone - analysis |
| title | An immunohistochemical study of endogenous estradiol and testosterone in human colo-rectal cancer tissues |
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