Effect of combined administration of HBs antigen and anti-HBs antibody on induction of anti-HBs antibody production in vitro and in vivo
It was considered that nonresponsiveness to hepatitis B surface antigen was in part due to a failure in the antigen recognition (i.e., antigens' phagocytosis, processing and presentation by accessory cells). In order to enhance the capture of antigens, we investigated the effect of simultaneous...
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| Veröffentlicht in: | Nippon Shokakibyo Gakkai Zasshi 1989, Vol.86(4), pp.897-904 |
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| container_issue | 4 |
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| container_title | Nippon Shokakibyo Gakkai Zasshi |
| container_volume | 86 |
| creator | KUMAGAI, Naoki TSUCHIMOTO, Kanji GOTOH, Youji TODA, Kyouko HIBI, Toshifumi MURAOKA, Matsuo TAKAHASHI, Takashi KAWAMURA, Eiji MORIZANE, Toshio TSUCHIYA, Masaharu |
| description | It was considered that nonresponsiveness to hepatitis B surface antigen was in part due to a failure in the antigen recognition (i.e., antigens' phagocytosis, processing and presentation by accessory cells). In order to enhance the capture of antigens, we investigated the effect of simultaneous administration of HBs antigen and anti-HBs IgG on antibody responses in vitro and in vivo. As a result, in vitro sensitization of mononuclear cells from anti-HBs-positive subjects with HBs antigen and anti-HBs IgG induced significant amounts of anti-HBs IgG production in 5 of 6 cases, whereas sensitization with HBs antigen alone failed to induce the antibody production in most cases. In vivo administration of HBs vaccine and anti-HBs immunoglobulin to non-responders to the vaccine triggered active anti-HBs antibody responses in 3 of 7 cases in vivo and in 5 of 7 cases in vitro. |
| doi_str_mv | 10.11405/nisshoshi1964.86.897 |
| format | Article |
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In order to enhance the capture of antigens, we investigated the effect of simultaneous administration of HBs antigen and anti-HBs IgG on antibody responses in vitro and in vivo. As a result, in vitro sensitization of mononuclear cells from anti-HBs-positive subjects with HBs antigen and anti-HBs IgG induced significant amounts of anti-HBs IgG production in 5 of 6 cases, whereas sensitization with HBs antigen alone failed to induce the antibody production in most cases. In vivo administration of HBs vaccine and anti-HBs immunoglobulin to non-responders to the vaccine triggered active anti-HBs antibody responses in 3 of 7 cases in vivo and in 5 of 7 cases in vitro.</description><identifier>ISSN: 0446-6586</identifier><identifier>EISSN: 1349-7693</identifier><identifier>DOI: 10.11405/nisshoshi1964.86.897</identifier><identifier>PMID: 2754841</identifier><language>jpn</language><publisher>Japan: The Japanese Society of Gastroenterology</publisher><subject>Hepatitis B Antibodies - biosynthesis ; Hepatitis B Surface Antigens - immunology ; Hepatitis B virus - immunology ; Humans ; Immunoglobulin G - administration & dosage ; Immunoglobulin G - pharmacology ; in vitro sensitization ; non-responder ; Stimulation, Chemical ; Viral Vaccines - administration & dosage ; Viral Vaccines - pharmacology</subject><ispartof>Nippon Shokakibyo Gakkai Zasshi, 1989, Vol.86(4), pp.897-904</ispartof><rights>The Japanese Society of Gastroenterology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2754841$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KUMAGAI, Naoki</creatorcontrib><creatorcontrib>TSUCHIMOTO, Kanji</creatorcontrib><creatorcontrib>GOTOH, Youji</creatorcontrib><creatorcontrib>TODA, Kyouko</creatorcontrib><creatorcontrib>HIBI, Toshifumi</creatorcontrib><creatorcontrib>MURAOKA, Matsuo</creatorcontrib><creatorcontrib>TAKAHASHI, Takashi</creatorcontrib><creatorcontrib>KAWAMURA, Eiji</creatorcontrib><creatorcontrib>MORIZANE, Toshio</creatorcontrib><creatorcontrib>TSUCHIYA, Masaharu</creatorcontrib><title>Effect of combined administration of HBs antigen and anti-HBs antibody on induction of anti-HBs antibody production in vitro and in vivo</title><title>Nippon Shokakibyo Gakkai Zasshi</title><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><description>It was considered that nonresponsiveness to hepatitis B surface antigen was in part due to a failure in the antigen recognition (i.e., antigens' phagocytosis, processing and presentation by accessory cells). In order to enhance the capture of antigens, we investigated the effect of simultaneous administration of HBs antigen and anti-HBs IgG on antibody responses in vitro and in vivo. As a result, in vitro sensitization of mononuclear cells from anti-HBs-positive subjects with HBs antigen and anti-HBs IgG induced significant amounts of anti-HBs IgG production in 5 of 6 cases, whereas sensitization with HBs antigen alone failed to induce the antibody production in most cases. In vivo administration of HBs vaccine and anti-HBs immunoglobulin to non-responders to the vaccine triggered active anti-HBs antibody responses in 3 of 7 cases in vivo and in 5 of 7 cases in vitro.</description><subject>Hepatitis B Antibodies - biosynthesis</subject><subject>Hepatitis B Surface Antigens - immunology</subject><subject>Hepatitis B virus - immunology</subject><subject>Humans</subject><subject>Immunoglobulin G - administration & dosage</subject><subject>Immunoglobulin G - pharmacology</subject><subject>in vitro sensitization</subject><subject>non-responder</subject><subject>Stimulation, Chemical</subject><subject>Viral Vaccines - administration & dosage</subject><subject>Viral Vaccines - pharmacology</subject><issn>0446-6586</issn><issn>1349-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkctKAzEUhoMotdQ-QmFW7qZOLpPLUovaQsGNrofcpk3pJHWSFvoGPrbTK4ibnCTfd35yAWAEizGEpCifvItxGeLSQUHJmNMxF-wG9CEmImdU4FvQLwihOS05vQfDGJ0qikKUgmPcAz3ESsIJ7IOf17q2OmWhznRolPPWZNI0rstPrUwu-AOavsRM-uQW1nfVHOf5ZVMFs886z3mz1ZeO_8amDRfufLZzqQ3HrONiFx7AXS3X0Q7PdQC-3l4_J9N8_vE-mzzP8xUiJOWcaoKVVFRDbAoNZWlQdxWIobBWMYFQLSgyooayVrjGDAlrYGEZ50YJjvAAPJ5yu_N8b21MVeOituu19DZsY8UERIyQgzg6i1vVWFNtWtfIdl-dn67jsxNfxSQX9splm5xe2-rPD1WcVpdBsKujl7KtrMe_s_GQTA</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>KUMAGAI, Naoki</creator><creator>TSUCHIMOTO, Kanji</creator><creator>GOTOH, Youji</creator><creator>TODA, Kyouko</creator><creator>HIBI, Toshifumi</creator><creator>MURAOKA, Matsuo</creator><creator>TAKAHASHI, Takashi</creator><creator>KAWAMURA, Eiji</creator><creator>MORIZANE, Toshio</creator><creator>TSUCHIYA, Masaharu</creator><general>The Japanese Society of Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Effect of combined administration of HBs antigen and anti-HBs antibody on induction of anti-HBs antibody production in vitro and in vivo</title><author>KUMAGAI, Naoki ; TSUCHIMOTO, Kanji ; GOTOH, Youji ; TODA, Kyouko ; HIBI, Toshifumi ; MURAOKA, Matsuo ; TAKAHASHI, Takashi ; KAWAMURA, Eiji ; MORIZANE, Toshio ; TSUCHIYA, Masaharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j244t-86c43bab6c13d0c1a5d25481319eeb7922f962d9f1afb3f3729ed10e788db9823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1989</creationdate><topic>Hepatitis B Antibodies - biosynthesis</topic><topic>Hepatitis B Surface Antigens - immunology</topic><topic>Hepatitis B virus - immunology</topic><topic>Humans</topic><topic>Immunoglobulin G - administration & dosage</topic><topic>Immunoglobulin G - pharmacology</topic><topic>in vitro sensitization</topic><topic>non-responder</topic><topic>Stimulation, Chemical</topic><topic>Viral Vaccines - administration & dosage</topic><topic>Viral Vaccines - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>KUMAGAI, Naoki</creatorcontrib><creatorcontrib>TSUCHIMOTO, Kanji</creatorcontrib><creatorcontrib>GOTOH, Youji</creatorcontrib><creatorcontrib>TODA, Kyouko</creatorcontrib><creatorcontrib>HIBI, Toshifumi</creatorcontrib><creatorcontrib>MURAOKA, Matsuo</creatorcontrib><creatorcontrib>TAKAHASHI, Takashi</creatorcontrib><creatorcontrib>KAWAMURA, Eiji</creatorcontrib><creatorcontrib>MORIZANE, Toshio</creatorcontrib><creatorcontrib>TSUCHIYA, Masaharu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KUMAGAI, Naoki</au><au>TSUCHIMOTO, Kanji</au><au>GOTOH, Youji</au><au>TODA, Kyouko</au><au>HIBI, Toshifumi</au><au>MURAOKA, Matsuo</au><au>TAKAHASHI, Takashi</au><au>KAWAMURA, Eiji</au><au>MORIZANE, Toshio</au><au>TSUCHIYA, Masaharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of combined administration of HBs antigen and anti-HBs antibody on induction of anti-HBs antibody production in vitro and in vivo</atitle><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><date>1989</date><risdate>1989</risdate><volume>86</volume><issue>4</issue><spage>897</spage><epage>904</epage><pages>897-904</pages><issn>0446-6586</issn><eissn>1349-7693</eissn><abstract>It was considered that nonresponsiveness to hepatitis B surface antigen was in part due to a failure in the antigen recognition (i.e., antigens' phagocytosis, processing and presentation by accessory cells). In order to enhance the capture of antigens, we investigated the effect of simultaneous administration of HBs antigen and anti-HBs IgG on antibody responses in vitro and in vivo. As a result, in vitro sensitization of mononuclear cells from anti-HBs-positive subjects with HBs antigen and anti-HBs IgG induced significant amounts of anti-HBs IgG production in 5 of 6 cases, whereas sensitization with HBs antigen alone failed to induce the antibody production in most cases. In vivo administration of HBs vaccine and anti-HBs immunoglobulin to non-responders to the vaccine triggered active anti-HBs antibody responses in 3 of 7 cases in vivo and in 5 of 7 cases in vitro.</abstract><cop>Japan</cop><pub>The Japanese Society of Gastroenterology</pub><pmid>2754841</pmid><doi>10.11405/nisshoshi1964.86.897</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0446-6586 |
| ispartof | Nippon Shokakibyo Gakkai Zasshi, 1989, Vol.86(4), pp.897-904 |
| issn | 0446-6586 1349-7693 |
| language | jpn |
| recordid | cdi_proquest_miscellaneous_79127442 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Hepatitis B Antibodies - biosynthesis Hepatitis B Surface Antigens - immunology Hepatitis B virus - immunology Humans Immunoglobulin G - administration & dosage Immunoglobulin G - pharmacology in vitro sensitization non-responder Stimulation, Chemical Viral Vaccines - administration & dosage Viral Vaccines - pharmacology |
| title | Effect of combined administration of HBs antigen and anti-HBs antibody on induction of anti-HBs antibody production in vitro and in vivo |
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