Sex difference in the CD4 + CD45R + T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura
Chronic idiopathic thrombocytopenic purpura (ITP) is a well-defined autoimmune hematologic disorder. It is more common in women than men. We have shown that patients with active disease have abnormal T cell subsets which are more perturbed in women than in men and functional abnormalities that are c...
Gespeichert in:
| Veröffentlicht in: | Clinical immunology and immunopathology 1989-09, Vol.52 (3), p.473-485 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 485 |
|---|---|
| container_issue | 3 |
| container_start_page | 473 |
| container_title | Clinical immunology and immunopathology |
| container_volume | 52 |
| creator | Mylvaganam, Ravindra Ahn, Yeon S. Sprinz, Philippa G. Garcia, Rolando O. Harrington, William J. |
| description | Chronic idiopathic thrombocytopenic purpura (ITP) is a well-defined autoimmune hematologic disorder. It is more common in women than men. We have shown that patients with active disease have abnormal T cell subsets which are more perturbed in women than in men and functional abnormalities that are confined to the T lymphocytes. In the current study, the anti-2H4 (CD45R) monoclonal antibody was used to divide the CD4 subset into their CD4+CD45R+ and CD4+CD45R− T lymphocytes. The sub-populations were measured in the peripheral blood of 26 women and 15 men with active ITP, 16 women and 8 men with disease in remission, and 33 normal healthy women and men. Normal women had increased percentages (
P < 0.0001) and numbers (
P < 0.005) of the CD4+CD45R+ lymphocytes compared to normal men. Women with active disease had reduced percentages and numbers of CD4+CD45R+ lymphocytes compared to normal women (
P < 0.0001) and women with disease in remission (
P < 0.001). Those women with decreased CD4+CD45R+ lymphocytes had a significantly depressed lymphocyte response to polyclonal T cell mitogens. In contrast, men with active disease had neither such phenotypic changes nor functional correlations. The percentages and numbers of CD4+CD45R− lymphocytes were not changed in either sex with active disease. In conclusion, women, but not men, with active ITP appear to possess a reduced sub-population of CD4+CD45R+ T lymphocytes. |
| doi_str_mv | 10.1016/0090-1229(89)90161-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79127238</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>009012298990161X</els_id><sourcerecordid>79127238</sourcerecordid><originalsourceid>FETCH-LOGICAL-c332t-a1954a07c37304d1b8f25800e4222c31cf16319da80e035ab9cd47a73c4d8e433</originalsourceid><addsrcrecordid>eNqFkd9qFDEUxoNY6lp9A4VcSLHIaP7NZnIjlLW1QkHQCr0L2eQMG5mZjMnM1n0PH9iku-ylQjgnnPOd74T8EHpFyXtK6PIDIYpUlDH1tlEXKldodf8ELWgpMy7oU7Q4Sp6h5yn9JIQsBZGn6JTVTGaTBfrzHX5j59sWIgwWsB_wtAG8-iTwuxLrbznf4W7Xj5tgdxOkIhlC7E2Xb85vvZtNl7AZHPZTwgk6sJPfAnZgI5j06PkQesjRTxvsnQ-jmTbe5k0x9OtiG0YYcmGcYz7mBTppsye8POQz9OP66m51U91-_fxldXlbWc7ZVBmqamGItFxyIhxdNy2rG0JAMMYsp7alS06VMw0BwmuzVtYJaSS3wjUgOD9D53vfMYZfM6RJ9z5Z6DozQJiTlooyyXjzXyGtuahpTbJQ7IU2hpQitHqMvjdxpynRhZouSHRBohulH6np-zz2-uA_r3twx6EDptx_c-ibZE3XRjNYn46ypWJcyrL9414G-dO2HqJO1heszscMRbvg__2OvyOss1g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15345150</pqid></control><display><type>article</type><title>Sex difference in the CD4 + CD45R + T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Mylvaganam, Ravindra ; Ahn, Yeon S. ; Sprinz, Philippa G. ; Garcia, Rolando O. ; Harrington, William J.</creator><creatorcontrib>Mylvaganam, Ravindra ; Ahn, Yeon S. ; Sprinz, Philippa G. ; Garcia, Rolando O. ; Harrington, William J.</creatorcontrib><description>Chronic idiopathic thrombocytopenic purpura (ITP) is a well-defined autoimmune hematologic disorder. It is more common in women than men. We have shown that patients with active disease have abnormal T cell subsets which are more perturbed in women than in men and functional abnormalities that are confined to the T lymphocytes. In the current study, the anti-2H4 (CD45R) monoclonal antibody was used to divide the CD4 subset into their CD4+CD45R+ and CD4+CD45R− T lymphocytes. The sub-populations were measured in the peripheral blood of 26 women and 15 men with active ITP, 16 women and 8 men with disease in remission, and 33 normal healthy women and men. Normal women had increased percentages (
P < 0.0001) and numbers (
P < 0.005) of the CD4+CD45R+ lymphocytes compared to normal men. Women with active disease had reduced percentages and numbers of CD4+CD45R+ lymphocytes compared to normal women (
P < 0.0001) and women with disease in remission (
P < 0.001). Those women with decreased CD4+CD45R+ lymphocytes had a significantly depressed lymphocyte response to polyclonal T cell mitogens. In contrast, men with active disease had neither such phenotypic changes nor functional correlations. The percentages and numbers of CD4+CD45R− lymphocytes were not changed in either sex with active disease. In conclusion, women, but not men, with active ITP appear to possess a reduced sub-population of CD4+CD45R+ T lymphocytes.</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1016/0090-1229(89)90161-X</identifier><identifier>PMID: 2527101</identifier><identifier>CODEN: CLIIAT</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Antibodies, Monoclonal ; Antigens, Differentiation - analysis ; Antigens, Differentiation, T-Lymphocyte - analysis ; Autoimmunity (experimental aspects and models) ; Biological and medical sciences ; CD8 Antigens ; Cells, Cultured ; Danazol - therapeutic use ; Female ; Flow Cytometry ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Histocompatibility Antigens - analysis ; Humans ; Leukocyte Common Antigens ; Male ; Reference Values ; Sex Factors ; T-Lymphocytes - immunology ; Thrombocytopenia - drug therapy ; Thrombocytopenia - immunology</subject><ispartof>Clinical immunology and immunopathology, 1989-09, Vol.52 (3), p.473-485</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-a1954a07c37304d1b8f25800e4222c31cf16319da80e035ab9cd47a73c4d8e433</citedby><cites>FETCH-LOGICAL-c332t-a1954a07c37304d1b8f25800e4222c31cf16319da80e035ab9cd47a73c4d8e433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6923770$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2527101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mylvaganam, Ravindra</creatorcontrib><creatorcontrib>Ahn, Yeon S.</creatorcontrib><creatorcontrib>Sprinz, Philippa G.</creatorcontrib><creatorcontrib>Garcia, Rolando O.</creatorcontrib><creatorcontrib>Harrington, William J.</creatorcontrib><title>Sex difference in the CD4 + CD45R + T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura</title><title>Clinical immunology and immunopathology</title><addtitle>Clin Immunol Immunopathol</addtitle><description>Chronic idiopathic thrombocytopenic purpura (ITP) is a well-defined autoimmune hematologic disorder. It is more common in women than men. We have shown that patients with active disease have abnormal T cell subsets which are more perturbed in women than in men and functional abnormalities that are confined to the T lymphocytes. In the current study, the anti-2H4 (CD45R) monoclonal antibody was used to divide the CD4 subset into their CD4+CD45R+ and CD4+CD45R− T lymphocytes. The sub-populations were measured in the peripheral blood of 26 women and 15 men with active ITP, 16 women and 8 men with disease in remission, and 33 normal healthy women and men. Normal women had increased percentages (
P < 0.0001) and numbers (
P < 0.005) of the CD4+CD45R+ lymphocytes compared to normal men. Women with active disease had reduced percentages and numbers of CD4+CD45R+ lymphocytes compared to normal women (
P < 0.0001) and women with disease in remission (
P < 0.001). Those women with decreased CD4+CD45R+ lymphocytes had a significantly depressed lymphocyte response to polyclonal T cell mitogens. In contrast, men with active disease had neither such phenotypic changes nor functional correlations. The percentages and numbers of CD4+CD45R− lymphocytes were not changed in either sex with active disease. In conclusion, women, but not men, with active ITP appear to possess a reduced sub-population of CD4+CD45R+ T lymphocytes.</description><subject>Antibodies, Monoclonal</subject><subject>Antigens, Differentiation - analysis</subject><subject>Antigens, Differentiation, T-Lymphocyte - analysis</subject><subject>Autoimmunity (experimental aspects and models)</subject><subject>Biological and medical sciences</subject><subject>CD8 Antigens</subject><subject>Cells, Cultured</subject><subject>Danazol - therapeutic use</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Histocompatibility Antigens - analysis</subject><subject>Humans</subject><subject>Leukocyte Common Antigens</subject><subject>Male</subject><subject>Reference Values</subject><subject>Sex Factors</subject><subject>T-Lymphocytes - immunology</subject><subject>Thrombocytopenia - drug therapy</subject><subject>Thrombocytopenia - immunology</subject><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9qFDEUxoNY6lp9A4VcSLHIaP7NZnIjlLW1QkHQCr0L2eQMG5mZjMnM1n0PH9iku-ylQjgnnPOd74T8EHpFyXtK6PIDIYpUlDH1tlEXKldodf8ELWgpMy7oU7Q4Sp6h5yn9JIQsBZGn6JTVTGaTBfrzHX5j59sWIgwWsB_wtAG8-iTwuxLrbznf4W7Xj5tgdxOkIhlC7E2Xb85vvZtNl7AZHPZTwgk6sJPfAnZgI5j06PkQesjRTxvsnQ-jmTbe5k0x9OtiG0YYcmGcYz7mBTppsye8POQz9OP66m51U91-_fxldXlbWc7ZVBmqamGItFxyIhxdNy2rG0JAMMYsp7alS06VMw0BwmuzVtYJaSS3wjUgOD9D53vfMYZfM6RJ9z5Z6DozQJiTlooyyXjzXyGtuahpTbJQ7IU2hpQitHqMvjdxpynRhZouSHRBohulH6np-zz2-uA_r3twx6EDptx_c-ibZE3XRjNYn46ypWJcyrL9414G-dO2HqJO1heszscMRbvg__2OvyOss1g</recordid><startdate>198909</startdate><enddate>198909</enddate><creator>Mylvaganam, Ravindra</creator><creator>Ahn, Yeon S.</creator><creator>Sprinz, Philippa G.</creator><creator>Garcia, Rolando O.</creator><creator>Harrington, William J.</creator><general>Elsevier Inc</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198909</creationdate><title>Sex difference in the CD4 + CD45R + T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura</title><author>Mylvaganam, Ravindra ; Ahn, Yeon S. ; Sprinz, Philippa G. ; Garcia, Rolando O. ; Harrington, William J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-a1954a07c37304d1b8f25800e4222c31cf16319da80e035ab9cd47a73c4d8e433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Antibodies, Monoclonal</topic><topic>Antigens, Differentiation - analysis</topic><topic>Antigens, Differentiation, T-Lymphocyte - analysis</topic><topic>Autoimmunity (experimental aspects and models)</topic><topic>Biological and medical sciences</topic><topic>CD8 Antigens</topic><topic>Cells, Cultured</topic><topic>Danazol - therapeutic use</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Histocompatibility Antigens - analysis</topic><topic>Humans</topic><topic>Leukocyte Common Antigens</topic><topic>Male</topic><topic>Reference Values</topic><topic>Sex Factors</topic><topic>T-Lymphocytes - immunology</topic><topic>Thrombocytopenia - drug therapy</topic><topic>Thrombocytopenia - immunology</topic><toplevel>online_resources</toplevel><creatorcontrib>Mylvaganam, Ravindra</creatorcontrib><creatorcontrib>Ahn, Yeon S.</creatorcontrib><creatorcontrib>Sprinz, Philippa G.</creatorcontrib><creatorcontrib>Garcia, Rolando O.</creatorcontrib><creatorcontrib>Harrington, William J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mylvaganam, Ravindra</au><au>Ahn, Yeon S.</au><au>Sprinz, Philippa G.</au><au>Garcia, Rolando O.</au><au>Harrington, William J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex difference in the CD4 + CD45R + T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1989-09</date><risdate>1989</risdate><volume>52</volume><issue>3</issue><spage>473</spage><epage>485</epage><pages>473-485</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><coden>CLIIAT</coden><abstract>Chronic idiopathic thrombocytopenic purpura (ITP) is a well-defined autoimmune hematologic disorder. It is more common in women than men. We have shown that patients with active disease have abnormal T cell subsets which are more perturbed in women than in men and functional abnormalities that are confined to the T lymphocytes. In the current study, the anti-2H4 (CD45R) monoclonal antibody was used to divide the CD4 subset into their CD4+CD45R+ and CD4+CD45R− T lymphocytes. The sub-populations were measured in the peripheral blood of 26 women and 15 men with active ITP, 16 women and 8 men with disease in remission, and 33 normal healthy women and men. Normal women had increased percentages (
P < 0.0001) and numbers (
P < 0.005) of the CD4+CD45R+ lymphocytes compared to normal men. Women with active disease had reduced percentages and numbers of CD4+CD45R+ lymphocytes compared to normal women (
P < 0.0001) and women with disease in remission (
P < 0.001). Those women with decreased CD4+CD45R+ lymphocytes had a significantly depressed lymphocyte response to polyclonal T cell mitogens. In contrast, men with active disease had neither such phenotypic changes nor functional correlations. The percentages and numbers of CD4+CD45R− lymphocytes were not changed in either sex with active disease. In conclusion, women, but not men, with active ITP appear to possess a reduced sub-population of CD4+CD45R+ T lymphocytes.</abstract><cop>San Diego, CA</cop><cop>New York, NY</cop><cop>Boston</cop><pub>Elsevier Inc</pub><pmid>2527101</pmid><doi>10.1016/0090-1229(89)90161-X</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-1229 |
| ispartof | Clinical immunology and immunopathology, 1989-09, Vol.52 (3), p.473-485 |
| issn | 0090-1229 1090-2341 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79127238 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Antibodies, Monoclonal Antigens, Differentiation - analysis Antigens, Differentiation, T-Lymphocyte - analysis Autoimmunity (experimental aspects and models) Biological and medical sciences CD8 Antigens Cells, Cultured Danazol - therapeutic use Female Flow Cytometry Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Fundamental immunology Histocompatibility Antigens - analysis Humans Leukocyte Common Antigens Male Reference Values Sex Factors T-Lymphocytes - immunology Thrombocytopenia - drug therapy Thrombocytopenia - immunology |
| title | Sex difference in the CD4 + CD45R + T lymphocytes in normal individuals and its selective decrease in women with idiopathic thrombocytopenic purpura |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T19%3A32%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sex%20difference%20in%20the%20CD4%20+%20CD45R%20+%20T%20lymphocytes%20in%20normal%20individuals%20and%20its%20selective%20decrease%20in%20women%20with%20idiopathic%20thrombocytopenic%20purpura&rft.jtitle=Clinical%20immunology%20and%20immunopathology&rft.au=Mylvaganam,%20Ravindra&rft.date=1989-09&rft.volume=52&rft.issue=3&rft.spage=473&rft.epage=485&rft.pages=473-485&rft.issn=0090-1229&rft.eissn=1090-2341&rft.coden=CLIIAT&rft_id=info:doi/10.1016/0090-1229(89)90161-X&rft_dat=%3Cproquest_cross%3E79127238%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=15345150&rft_id=info:pmid/2527101&rft_els_id=009012298990161X&rfr_iscdi=true |