High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin-cholesteryl acyltransferase

A subset of patients with high plasma HDL concentrations have enhanced rather than reduced atherosclerosis. We have developed a new transgenic mouse model overexpressing human lecithin-cholesteryl acyltransferase (LCAT) that has elevated HDL and increased diet-induced atherosclerosis. LCAT transgeni...

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Veröffentlicht in:	Nature medicine 1997-07, Vol.3 (7), p.744-749
Hauptverfasser:	Bérard, A M, Föger, B, Remaley, A, Shamburek, R, Vaisman, B L, Talley, G, Paigen, B, Hoyt, Jr, R F, Marcovina, S, Brewer, Jr, H B, Santamarina-Fojo, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - pathology Arteriosclerosis - blood Arteriosclerosis - enzymology Arteriosclerosis - pathology Cholesterol - blood Diet, Atherogenic Disease Models, Animal Female Humans Lipids - blood Lipoproteins, HDL - blood Lipoproteins, HDL - chemistry Lipoproteins, HDL - physiology Male Mice Mice, Transgenic Phosphatidylcholine-Sterol O-Acyltransferase - biosynthesis Phosphatidylcholine-Sterol O-Acyltransferase - genetics Phosphatidylcholine-Sterol O-Acyltransferase - metabolism
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