Detection of Kell blood groups: molecular methods in the diagnostic laboratory
The introduction of molecular biology techniques to the field of transfusion medicine has allowed more detailed analysis of the basis for the expression of several blood-group antigens. The application of the polymerase chain reaction for the determination of red-cell blood-group genotype is a highl...
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| Veröffentlicht in: | Blood reviews 1997-03, Vol.11 (1), p.8-15 |
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| container_title | Blood reviews |
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| creator | Murphy, M.T. Fraser, R.H. |
| description | The introduction of molecular biology techniques to the field of transfusion medicine has allowed more detailed analysis of the basis for the expression of several blood-group antigens. The application of the polymerase chain reaction for the determination of red-cell blood-group genotype is a highly sensitive technique that can be used to determine the likelihood of a fetus being affected by haemolytic disease of the fetus or newborn. This alone makes polymerase chain reaction based techniques highly desirable for such applications. The determination of the genetic basis for the Kell/Cellano polymorphism has enabled the development of polymerase chain reaction-based techniques for genotyping. Several other red-cell blood-group antigen polymorphisms can also be analysed in this way. |
| doi_str_mv | 10.1016/S0268-960X(97)90002-3 |
| format | Article |
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The application of the polymerase chain reaction for the determination of red-cell blood-group genotype is a highly sensitive technique that can be used to determine the likelihood of a fetus being affected by haemolytic disease of the fetus or newborn. This alone makes polymerase chain reaction based techniques highly desirable for such applications. The determination of the genetic basis for the Kell/Cellano polymorphism has enabled the development of polymerase chain reaction-based techniques for genotyping. Several other red-cell blood-group antigen polymorphisms can also be analysed in this way.</description><identifier>ISSN: 0268-960X</identifier><identifier>EISSN: 1532-1681</identifier><identifier>DOI: 10.1016/S0268-960X(97)90002-3</identifier><identifier>PMID: 9218102</identifier><language>eng</language><publisher>Kent: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Blood Grouping and Crossmatching - methods ; DNA Mutational Analysis ; Fundamental and applied biological sciences. 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The application of the polymerase chain reaction for the determination of red-cell blood-group genotype is a highly sensitive technique that can be used to determine the likelihood of a fetus being affected by haemolytic disease of the fetus or newborn. This alone makes polymerase chain reaction based techniques highly desirable for such applications. The determination of the genetic basis for the Kell/Cellano polymorphism has enabled the development of polymerase chain reaction-based techniques for genotyping. Several other red-cell blood-group antigen polymorphisms can also be analysed in this way.</description><subject>Biological and medical sciences</subject><subject>Blood Grouping and Crossmatching - methods</subject><subject>DNA Mutational Analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunohematology</subject><subject>Kell Blood-Group System - analysis</subject><subject>Kell Blood-Group System - chemistry</subject><subject>Kell Blood-Group System - genetics</subject><subject>Red blood cell immunology</subject><issn>0268-960X</issn><issn>1532-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP3DAURq2qFR2m_AQkL1AFixRfJ3FsNggNtCBG7aJF6s5y_GBcJfFgJ0j8-3oemi2ru7jnu4-D0CmQb0CAXf4mlPFCMPL3XDQXghBCi_IDmkFd0gIYh49odkA-o-OU_mVGlKw5QkeCAgdCZ-jnrR2tHn0YcHD40XYdbrsQDH6OYVqnK9yHzuqpUxH3dlwFk7Af8Liy2Hj1PIQ0eo071YaoxhDfvqBPTnXJnuzrHD19v_uzuC-Wv348LG6WhS65GAugpNYtq4VxrIIGmOCCceM050JpUbVOadDGtRUTtsrfUigpQMtrV3LlqnKOvu7mrmN4mWwaZe-TzterwYYpyUZAfp3VGax3oI4hpWidXEffq_gmgciNR7n1KDeSpGjk1qMsc-50v2Bqe2sOqb243D_b91XSqnNRDdqnA0aZqCrYjLneYTbLePU2yqS9HbQ1Pmbt0gT_ziH_Ae94jzY</recordid><startdate>19970301</startdate><enddate>19970301</enddate><creator>Murphy, M.T.</creator><creator>Fraser, R.H.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970301</creationdate><title>Detection of Kell blood groups: molecular methods in the diagnostic laboratory</title><author>Murphy, M.T. ; Fraser, R.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-1205cb659df64171698968dfc889ac94bfac1cdfb469e4016213211b85f38af43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Blood Grouping and Crossmatching - methods</topic><topic>DNA Mutational Analysis</topic><topic>Fundamental and applied biological sciences. 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| fulltext | fulltext |
| identifier | ISSN: 0268-960X |
| ispartof | Blood reviews, 1997-03, Vol.11 (1), p.8-15 |
| issn | 0268-960X 1532-1681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79126865 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Blood Grouping and Crossmatching - methods DNA Mutational Analysis Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunohematology Kell Blood-Group System - analysis Kell Blood-Group System - chemistry Kell Blood-Group System - genetics Red blood cell immunology |
| title | Detection of Kell blood groups: molecular methods in the diagnostic laboratory |
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