Inhibitory effect of high caloric load of carbohydrates or lipids on human pancreatic secretions: a jejunal brake
Effects of jejunal infusion of a saline solution, a protein meal, and a mixed protein and carbohydrate meal on biliopancreatic secretions were compared in six healthy volunteers. Protein infusion stimulated biliopancreatic secretions whereas carbohydrate infusion inhibited these secretions compared...
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| Veröffentlicht in: | The American journal of clinical nutrition 1989-08, Vol.50 (2), p.231-236 |
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| creator | Vidon, N Chaussade, S Merite, F Huchet, B Franchisseur, C Bernier, J J |
| description | Effects of jejunal infusion of a saline solution, a protein meal, and a mixed protein and carbohydrate meal on biliopancreatic secretions were compared in six healthy volunteers. Protein infusion stimulated biliopancreatic secretions whereas carbohydrate infusion inhibited these secretions compared with saline infusion. The roles of lipid, carbohydrate, and caloric load on the inhibition of pancreatic secretions by jejunal infusion of nutrients was investigated in six other healthy volunteers. Carbohydrate, lipid, and the mixed meal inhibited pancreatic secretions whereas the carbohydrate solution was the only one that inhibited biliary secretion. These studies indicate that the mechanism of jejunal brake seems mainly related to the jejunal caloric load. In malabsorption or in the short bowel syndrome, a high caloric load or unabsorbed nutrients in the jejunum further inhibits pancreatic secretion, contributing to the loss of nutrients from the intestinal tract. |
| doi_str_mv | 10.1093/ajcn/50.2.231 |
| format | Article |
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Protein infusion stimulated biliopancreatic secretions whereas carbohydrate infusion inhibited these secretions compared with saline infusion. The roles of lipid, carbohydrate, and caloric load on the inhibition of pancreatic secretions by jejunal infusion of nutrients was investigated in six other healthy volunteers. Carbohydrate, lipid, and the mixed meal inhibited pancreatic secretions whereas the carbohydrate solution was the only one that inhibited biliary secretion. These studies indicate that the mechanism of jejunal brake seems mainly related to the jejunal caloric load. In malabsorption or in the short bowel syndrome, a high caloric load or unabsorbed nutrients in the jejunum further inhibits pancreatic secretion, contributing to the loss of nutrients from the intestinal tract.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/50.2.231</identifier><identifier>PMID: 2756910</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>ABSORCION DE SUBSTANCIAS NUTRITIVAS ; ABSORPTION DE SUBSTANCES NUTRITIVES ; Adult ; Bile Acids and Salts - biosynthesis ; Biological and medical sciences ; CARBOHIDRATOS ; CORPS GRAS ; Dietary Carbohydrates - administration & dosage ; Dietary Fats - administration & dosage ; Energy Intake ; Exocrine pancreas ; Fundamental and applied biological sciences. Psychology ; GLUCIDE ; GRASAS ; HOMBRES ; HOMME ; Humans ; INTESTIN ; INTESTINOS ; Jejunum - drug effects ; JUGOS DIGESTIVOS ; Lipase - biosynthesis ; Male ; Pancreas - drug effects ; Pancreas - enzymology ; Pancreas - secretion ; SUC DIGESTIF ; VALEUR CALORIQUE ; VALOR CALORICO ; Vertebrates: digestive system</subject><ispartof>The American journal of clinical nutrition, 1989-08, Vol.50 (2), p.231-236</ispartof><rights>1989 American Society for Nutrition.</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-614f7926e6ba567383f40f4f0ab9e0ae44804e6f2e170c21b8a08e7920ed1d243</citedby><cites>FETCH-LOGICAL-c384t-614f7926e6ba567383f40f4f0ab9e0ae44804e6f2e170c21b8a08e7920ed1d243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6956986$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2756910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vidon, N</creatorcontrib><creatorcontrib>Chaussade, S</creatorcontrib><creatorcontrib>Merite, F</creatorcontrib><creatorcontrib>Huchet, B</creatorcontrib><creatorcontrib>Franchisseur, C</creatorcontrib><creatorcontrib>Bernier, J J</creatorcontrib><title>Inhibitory effect of high caloric load of carbohydrates or lipids on human pancreatic secretions: a jejunal brake</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>Effects of jejunal infusion of a saline solution, a protein meal, and a mixed protein and carbohydrate meal on biliopancreatic secretions were compared in six healthy volunteers. Protein infusion stimulated biliopancreatic secretions whereas carbohydrate infusion inhibited these secretions compared with saline infusion. The roles of lipid, carbohydrate, and caloric load on the inhibition of pancreatic secretions by jejunal infusion of nutrients was investigated in six other healthy volunteers. Carbohydrate, lipid, and the mixed meal inhibited pancreatic secretions whereas the carbohydrate solution was the only one that inhibited biliary secretion. These studies indicate that the mechanism of jejunal brake seems mainly related to the jejunal caloric load. In malabsorption or in the short bowel syndrome, a high caloric load or unabsorbed nutrients in the jejunum further inhibits pancreatic secretion, contributing to the loss of nutrients from the intestinal tract.</description><subject>ABSORCION DE SUBSTANCIAS NUTRITIVAS</subject><subject>ABSORPTION DE SUBSTANCES NUTRITIVES</subject><subject>Adult</subject><subject>Bile Acids and Salts - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>CARBOHIDRATOS</subject><subject>CORPS GRAS</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Dietary Fats - administration & dosage</subject><subject>Energy Intake</subject><subject>Exocrine pancreas</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GLUCIDE</subject><subject>GRASAS</subject><subject>HOMBRES</subject><subject>HOMME</subject><subject>Humans</subject><subject>INTESTIN</subject><subject>INTESTINOS</subject><subject>Jejunum - drug effects</subject><subject>JUGOS DIGESTIVOS</subject><subject>Lipase - biosynthesis</subject><subject>Male</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - enzymology</subject><subject>Pancreas - secretion</subject><subject>SUC DIGESTIF</subject><subject>VALEUR CALORIQUE</subject><subject>VALOR CALORICO</subject><subject>Vertebrates: digestive system</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1r3DAQhkVpSTdpj70ECjqU3LwZybZs9RaWfgQCPbQ5i7E8irXxWhvJLuy_r5ZdcutJg95nhuEZxj4JWAvQ5S1u7XRbw1quZSnesJXQZVuUEpq3bAUAstBC1e_ZZUpbACGrVl2wC9nUSgtYsZf7afCdn0M8cHKO7MyD44N_GrjFMURv-RiwP35ajF0YDn3EmRIPkY9-7_tcTXxYdjjxPU42Es65J1GuZh-m9JUj39J2mXDkXcRn-sDeORwTfTy_V-zx-7c_m5_Fw68f95u7h8KWbTUXSlSu0VKR6rBWTdmWrgJXOcBOEyBVVQsVKSdJNGCl6FqElnIHUC96WZVX7OY0dx_Dy0JpNjufLI0jThSWZBotpCprncHiBNoYUorkzD76HcaDEWCOis1RsanBSJMVZ_7zefDS7ah_pc9Oc_7lnGPKDl3MWnx6xZTOWKsydn3CHAaDTzEjj781QNOK4_LNKaRs6K-naJL1NFnqfcw3Mn3w_9nuH5r3oC0</recordid><startdate>19890801</startdate><enddate>19890801</enddate><creator>Vidon, N</creator><creator>Chaussade, S</creator><creator>Merite, F</creator><creator>Huchet, B</creator><creator>Franchisseur, C</creator><creator>Bernier, J J</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890801</creationdate><title>Inhibitory effect of high caloric load of carbohydrates or lipids on human pancreatic secretions: a jejunal brake</title><author>Vidon, N ; Chaussade, S ; Merite, F ; Huchet, B ; Franchisseur, C ; Bernier, J J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-614f7926e6ba567383f40f4f0ab9e0ae44804e6f2e170c21b8a08e7920ed1d243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>ABSORCION DE SUBSTANCIAS NUTRITIVAS</topic><topic>ABSORPTION DE SUBSTANCES NUTRITIVES</topic><topic>Adult</topic><topic>Bile Acids and Salts - biosynthesis</topic><topic>Biological and medical sciences</topic><topic>CARBOHIDRATOS</topic><topic>CORPS GRAS</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Dietary Fats - administration & dosage</topic><topic>Energy Intake</topic><topic>Exocrine pancreas</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GLUCIDE</topic><topic>GRASAS</topic><topic>HOMBRES</topic><topic>HOMME</topic><topic>Humans</topic><topic>INTESTIN</topic><topic>INTESTINOS</topic><topic>Jejunum - drug effects</topic><topic>JUGOS DIGESTIVOS</topic><topic>Lipase - biosynthesis</topic><topic>Male</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - enzymology</topic><topic>Pancreas - secretion</topic><topic>SUC DIGESTIF</topic><topic>VALEUR CALORIQUE</topic><topic>VALOR CALORICO</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vidon, N</creatorcontrib><creatorcontrib>Chaussade, S</creatorcontrib><creatorcontrib>Merite, F</creatorcontrib><creatorcontrib>Huchet, B</creatorcontrib><creatorcontrib>Franchisseur, C</creatorcontrib><creatorcontrib>Bernier, J J</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vidon, N</au><au>Chaussade, S</au><au>Merite, F</au><au>Huchet, B</au><au>Franchisseur, C</au><au>Bernier, J J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effect of high caloric load of carbohydrates or lipids on human pancreatic secretions: a jejunal brake</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1989-08-01</date><risdate>1989</risdate><volume>50</volume><issue>2</issue><spage>231</spage><epage>236</epage><pages>231-236</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>Effects of jejunal infusion of a saline solution, a protein meal, and a mixed protein and carbohydrate meal on biliopancreatic secretions were compared in six healthy volunteers. Protein infusion stimulated biliopancreatic secretions whereas carbohydrate infusion inhibited these secretions compared with saline infusion. The roles of lipid, carbohydrate, and caloric load on the inhibition of pancreatic secretions by jejunal infusion of nutrients was investigated in six other healthy volunteers. Carbohydrate, lipid, and the mixed meal inhibited pancreatic secretions whereas the carbohydrate solution was the only one that inhibited biliary secretion. These studies indicate that the mechanism of jejunal brake seems mainly related to the jejunal caloric load. In malabsorption or in the short bowel syndrome, a high caloric load or unabsorbed nutrients in the jejunum further inhibits pancreatic secretion, contributing to the loss of nutrients from the intestinal tract.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>2756910</pmid><doi>10.1093/ajcn/50.2.231</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | ABSORCION DE SUBSTANCIAS NUTRITIVAS ABSORPTION DE SUBSTANCES NUTRITIVES Adult Bile Acids and Salts - biosynthesis Biological and medical sciences CARBOHIDRATOS CORPS GRAS Dietary Carbohydrates - administration & dosage Dietary Fats - administration & dosage Energy Intake Exocrine pancreas Fundamental and applied biological sciences. Psychology GLUCIDE GRASAS HOMBRES HOMME Humans INTESTIN INTESTINOS Jejunum - drug effects JUGOS DIGESTIVOS Lipase - biosynthesis Male Pancreas - drug effects Pancreas - enzymology Pancreas - secretion SUC DIGESTIF VALEUR CALORIQUE VALOR CALORICO Vertebrates: digestive system |
| title | Inhibitory effect of high caloric load of carbohydrates or lipids on human pancreatic secretions: a jejunal brake |
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