Phosphorylation in vitro of vimentin by protein kinases A and C is restricted to the head domain: identification of the phosphoserine sites and their influence on filament formation

The in vitro phosphorylation of vimentin, the intermediate filament protein of mesenchymal cells, by kinases A and C is serine-specific and involves only the N-terminal head domain. In oligomeric protofilament units each kinase recognizes five sites, which have been identified by sequence analysis....

Ausführliche Beschreibung