Enantioselective determination of methadone and its main metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in serum, urine and hair by capillary electrophoresis

A capillary electrophoresis method has been developed for the enantioselective determination of methadone and its main metabolite 2‐ethylidene‐1,5‐dimethyl‐3,3‐diphenylpyrrolidine (EDDP) in serum and urine. After addition of the internal standard diphenhydramine, the serum and urine samples were ext...

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Veröffentlicht in:	Electrophoresis 1997, Vol.18 (6), p.1026-1034
Hauptverfasser:	Frost, Michael, Köhler, Helga, Blaschke, Gottfried
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Ethylidene-1 2‐Ethylidene‐1,5‐dimethyl‐3,3‐diphenylpyrrolidone 3-diphenylpyrrolidone 5-dimethyl-3 Capillary electrophoresis Electrophoresis, Capillary - methods Enantioselectivity Hair - chemistry Humans Methadone Methadone - analysis Methadone - blood Methadone - urine Molecular Conformation Pyrrolidines - analysis Pyrrolidines - blood Pyrrolidines - urine Street Drugs - analysis Street Drugs - blood Street Drugs - urine
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