Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentrations in children
The Ob protein leptin has been shown to be closely correlated with measures of body fat in humans and animals. Studies have suggested that there are both gender and ethnic differences in serum leptin concentrations, even after controlling for total and relative body fat and body mass index. We hypot...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 1997-07, Vol.82 (7), p.2148-2152 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | NAGY, T. R GOWER, B. A TROWBRIDGE, C. A DEZENBERG, C SHEWCHUK, R. M GORAN, M. I |
| description | The Ob protein leptin has been shown to be closely correlated with measures of body fat in humans and animals. Studies have suggested that there are both gender and ethnic differences in serum leptin concentrations, even after controlling for total and relative body fat and body mass index. We hypothesized that gender and ethnic differences in serum leptin concentrations are due to differences in both body composition and body fat distribution. We measured fasting serum leptin concentration, body composition (fat mass and fat-free mass by dual energy x-ray absorptiometry), and body fat distribution (intraabdominal and sc abdominal adipose tissue by computed tomography) in 74 prepubertal boys and girls (43 African-Americans and 31 Caucasians). Our results showed that gender differences in serum leptin concentrations could not be fully explained by differences in body mass index, total fat mass, or relative body composition. However, when serum leptin concentrations were adjusted for differences in relative body composition (fat mass and fat-free mass) and body fat distribution (sc and intraabdominal adipose tissue), gender no longer had an independent effect on the serum leptin concentration. Serum leptin concentrations were not influenced by ethnicity. Thus, when comparing group differences in serum leptin concentrations, it is necessary to adequately control for group differences in body composition and fat distribution. |
| doi_str_mv | 10.1210/jc.82.7.2148 |
| format | Article |
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Our results showed that gender differences in serum leptin concentrations could not be fully explained by differences in body mass index, total fat mass, or relative body composition. However, when serum leptin concentrations were adjusted for differences in relative body composition (fat mass and fat-free mass) and body fat distribution (sc and intraabdominal adipose tissue), gender no longer had an independent effect on the serum leptin concentration. Serum leptin concentrations were not influenced by ethnicity. Thus, when comparing group differences in serum leptin concentrations, it is necessary to adequately control for group differences in body composition and fat distribution.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.82.7.2148</identifier><identifier>PMID: 9215286</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adipose Tissue ; Age Factors ; Biological and medical sciences ; Body Composition ; Body Mass Index ; Child ; Child, Preschool ; Ethnic Groups ; Female ; Functional investigation of endocrine glands and genital system ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Leptin ; Linear Models ; Male ; Medical sciences ; Proteins - metabolism ; Sex</subject><ispartof>The journal of clinical endocrinology and metabolism, 1997-07, Vol.82 (7), p.2148-2152</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-bbed01c1549ac152cd5b90eadf2ac10dfe3842119b2119c14f750569fc3f908c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2737454$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9215286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAGY, T. R</creatorcontrib><creatorcontrib>GOWER, B. A</creatorcontrib><creatorcontrib>TROWBRIDGE, C. A</creatorcontrib><creatorcontrib>DEZENBERG, C</creatorcontrib><creatorcontrib>SHEWCHUK, R. M</creatorcontrib><creatorcontrib>GORAN, M. I</creatorcontrib><title>Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentrations in children</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>The Ob protein leptin has been shown to be closely correlated with measures of body fat in humans and animals. Studies have suggested that there are both gender and ethnic differences in serum leptin concentrations, even after controlling for total and relative body fat and body mass index. We hypothesized that gender and ethnic differences in serum leptin concentrations are due to differences in both body composition and body fat distribution. We measured fasting serum leptin concentration, body composition (fat mass and fat-free mass by dual energy x-ray absorptiometry), and body fat distribution (intraabdominal and sc abdominal adipose tissue by computed tomography) in 74 prepubertal boys and girls (43 African-Americans and 31 Caucasians). Our results showed that gender differences in serum leptin concentrations could not be fully explained by differences in body mass index, total fat mass, or relative body composition. However, when serum leptin concentrations were adjusted for differences in relative body composition (fat mass and fat-free mass) and body fat distribution (sc and intraabdominal adipose tissue), gender no longer had an independent effect on the serum leptin concentration. Serum leptin concentrations were not influenced by ethnicity. Thus, when comparing group differences in serum leptin concentrations, it is necessary to adequately control for group differences in body composition and fat distribution.</description><subject>Adipose Tissue</subject><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Ethnic Groups</subject><subject>Female</subject><subject>Functional investigation of endocrine glands and genital system</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Leptin</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Proteins - metabolism</subject><subject>Sex</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEFr3DAQhUVpSTdpb7kWdCg9rTcaWY6sYwhpEwjk0kBvQpZGiRZb2kjyYf99bbIEhjfMvG_m8Ai5BLYDDuxqb3c938kdB9F_IhtQomskKPmZbBjj0CjJ_30l56XsGQMhuvaMnCkOHe-vNyTdeY-2Fpo8fcHoMG8p1tcYbKjHLR2SO1KbpkMqoYYUt9RER72p1IVScxjmdUuXKpjniY54qCEuF9FirNmsbqHr5jWMLmP8Rr54Mxb8fuoX5Pn33d_b--bx6c_D7c1jY9seajMM6BhY6IQyi3LrukExNM7zZWbOY9sLDqCGVSwILzvWXStvW69Yb9sL8uv97yGntxlL1VMoFsfRRExz0VIB5y2IBdy-gzanUjJ6fchhMvmogek1X723uuda6jXfBf9x-jsPE7oP-BTo4v88-aZYM_psog3lA-OylaIT7X89jYRy</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>NAGY, T. R</creator><creator>GOWER, B. A</creator><creator>TROWBRIDGE, C. A</creator><creator>DEZENBERG, C</creator><creator>SHEWCHUK, R. M</creator><creator>GORAN, M. I</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970701</creationdate><title>Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentrations in children</title><author>NAGY, T. R ; GOWER, B. A ; TROWBRIDGE, C. A ; DEZENBERG, C ; SHEWCHUK, R. M ; GORAN, M. 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I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentrations in children</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>1997-07-01</date><risdate>1997</risdate><volume>82</volume><issue>7</issue><spage>2148</spage><epage>2152</epage><pages>2148-2152</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract>The Ob protein leptin has been shown to be closely correlated with measures of body fat in humans and animals. Studies have suggested that there are both gender and ethnic differences in serum leptin concentrations, even after controlling for total and relative body fat and body mass index. We hypothesized that gender and ethnic differences in serum leptin concentrations are due to differences in both body composition and body fat distribution. We measured fasting serum leptin concentration, body composition (fat mass and fat-free mass by dual energy x-ray absorptiometry), and body fat distribution (intraabdominal and sc abdominal adipose tissue by computed tomography) in 74 prepubertal boys and girls (43 African-Americans and 31 Caucasians). Our results showed that gender differences in serum leptin concentrations could not be fully explained by differences in body mass index, total fat mass, or relative body composition. However, when serum leptin concentrations were adjusted for differences in relative body composition (fat mass and fat-free mass) and body fat distribution (sc and intraabdominal adipose tissue), gender no longer had an independent effect on the serum leptin concentration. Serum leptin concentrations were not influenced by ethnicity. Thus, when comparing group differences in serum leptin concentrations, it is necessary to adequately control for group differences in body composition and fat distribution.</abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>9215286</pmid><doi>10.1210/jc.82.7.2148</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adipose Tissue Age Factors Biological and medical sciences Body Composition Body Mass Index Child Child, Preschool Ethnic Groups Female Functional investigation of endocrine glands and genital system Humans Investigative techniques, diagnostic techniques (general aspects) Leptin Linear Models Male Medical sciences Proteins - metabolism Sex |
| title | Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentrations in children |
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