Dexamethasone Increases Expression of 5‐Lipoxygenase and its Activating Protein in Human Monocytes and THP‐1 Cells

The aim of this study was to assess the effect of dexamethasone on 5‐lipoxygenase pathway expression in human peripheral blood monocytes and the acute monocytic leukemia cell line, THP‐1. Cells were conditioned over a period of days with dexamethasone, at concentrations relevant in vivo, to study th...

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Veröffentlicht in:	European journal of biochemistry 1997-05, Vol.246 (1), p.112-118
Hauptverfasser:	Riddick, Carl A., Ring, William L., Baker, Joseph R., Hodulik, Craig R., Bigby, Timothy D.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Lipoxygenase-Activating Proteins 5‐lipoxygenase 5‐lipoxygenase‐activating protein Arachidonate 5-Lipoxygenase - genetics Arachidonate 5-Lipoxygenase - metabolism arachidonic acid Arachidonic Acid - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Dexamethasone - pharmacology Dose-Response Relationship, Drug Enzyme Activation - drug effects Epoxide Hydrolases - metabolism Gene Expression Regulation - genetics glucocorticoid Humans Immunoblotting Indomethacin - pharmacology leukotriene Membrane Proteins - genetics Membrane Proteins - metabolism Monocytes - drug effects Monocytes - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Tumor Cells, Cultured
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