Synthesis of IGFBP-3 fragments in a baculovirus system and characterization of monoclonal anti-IGFBP-3 antibodies

IGFBPs play an important role in IGF biological actions by modulating IGF binding to its receptors. The major IGFBP in serum is IGFBP-3, which transports 70-90% of the circulating IGFs. In target cell systems, it sequesters IGFs and inhibits their hormonal actions, but may potentiate IGF activity or...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 1997-07, Vol.82 (7), p.2368-2370
Hauptverfasser:	VORWERK, P, OH, Y, LEE, P. D. K, KHARE, A, ROSENFELD, R. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Antibodies, Monoclonal - biosynthesis Baculoviridae - genetics Binding and carrier proteins Biological and medical sciences Blotting, Western Fundamental and applied biological sciences. Psychology Genetic Vectors Humans Insulin-Like Growth Factor Binding Protein 3 - biosynthesis Insulin-Like Growth Factor Binding Protein 3 - genetics Insulin-Like Growth Factor Binding Protein 3 - immunology Peptide Fragments - immunology Proteins Recombinant Proteins - immunology
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