Induction of Tyrosine Phosphorylation and Na+/H+Exchanger Activation during Shrinkage of Human Neutrophils

The ubiquitous isoform of the Na+/H+ exchanger (NHE1) is essential for the regulation of cellular volume. The underlying molecular mechanism, which is poorly understood, was studied in human polymorphonuclear leukocytes (PMN). Suspension of PMN in hypertonic media induced rapid cellular shrinkage an...

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Veröffentlicht in:	The Journal of biological chemistry 1997-07, Vol.272 (28), p.17303-17311
Hauptverfasser:	Krump, Eric, Nikitas, Kaliopi, Grinstein, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Size Cytosol - metabolism Enzyme Inhibitors - pharmacology Guanidines - pharmacology Humans Hydrogen-Ion Concentration Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 Mitogen-Activated Protein Kinases Neutrophils - cytology Neutrophils - metabolism Osmolar Concentration p38 Mitogen-Activated Protein Kinases Phosphorylation Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Sodium-Hydrogen Exchangers - metabolism src-Family Kinases - metabolism Sulfones - pharmacology Tyrosine - metabolism
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