Primary progressive multiple sclerosis
Patients with multiple sclerosis who develop progressive disability from onset without relapses or remissions pose difficulties in diagnosis, monitoring of disease activity and treatment. There is a need to define the diagnostic criteria for this group more precisely and, in particular, to describe...
Gespeichert in:
| Veröffentlicht in: | Brain (London, England : 1878) England : 1878), 1997-06, Vol.120 (6), p.1085-1096 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1096 |
|---|---|
| container_issue | 6 |
| container_start_page | 1085 |
| container_title | Brain (London, England : 1878) |
| container_volume | 120 |
| creator | THOMPSON, A. J POLMAN, C. H MILLER, D. H MCDONALD, W. I BROCHET, B FILIPPI, M MONTALBAN, X DE SA, J |
| description | Patients with multiple sclerosis who develop progressive disability from onset without relapses or remissions pose difficulties in diagnosis, monitoring of disease activity and treatment. There is a need to define the diagnostic criteria for this group more precisely and, in particular, to describe a comprehensive battery of investigations to exclude other conditions. The mechanisms underlying the development of disability and the role of MRI in monitoring disease activity in this clinical subgroup require elucidation, particularly in view of the lack of change on conventional imaging in the presence of continuing clinical deterioration. The prognosis is poor and there are currently no treatment trials for this form of the disease. |
| doi_str_mv | 10.1093/brain/120.6.1085 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79119182</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79119182</sourcerecordid><originalsourceid>FETCH-LOGICAL-c381t-df3d3c4950dc2ee787f8c94d40217dda4f7d897d9633e99c47a71e5905109ffe3</originalsourceid><addsrcrecordid>eNqFkEtLAzEQgIMotVbvXoQi0tu2M8luHkcpvqCgBz2HNMnKln3UpCv4703t4sGLEBjIfPP6CLlEmCMotlgHU7ULpDDn6UMWR2SMOYeMYsGPyRgAeCZVAafkLMYNAOaM8hEZKYqCKxyT2UuoGhO-ptvQvQcfY_Xpp01f76pt7afR1j50sYrn5KQ0dfQXQ5yQt_u71-Vjtnp-eFrerjLLJO4yVzLHbJ4GOku9F1KU0qrc5ZDmOWfyUjiphFOcMa-UzYUR6AsFRbqmLD2bkNmhb1rno_dxp5sqWl_XpvVdH7VQiAol_RekwDGtJBJ4_QfcdH1o0xEaVZEzQMkSBAfIpmtj8KXeHrRoBL0XrX9E6yRac70XnUquhr79uvHut2Awm_I3Q95Ea-oymNZW8RejAtKT7Bvex4Uf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>195430183</pqid></control><display><type>article</type><title>Primary progressive multiple sclerosis</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>THOMPSON, A. J ; POLMAN, C. H ; MILLER, D. H ; MCDONALD, W. I ; BROCHET, B ; FILIPPI, M ; MONTALBAN, X ; DE SA, J</creator><creatorcontrib>THOMPSON, A. J ; POLMAN, C. H ; MILLER, D. H ; MCDONALD, W. I ; BROCHET, B ; FILIPPI, M ; MONTALBAN, X ; DE SA, J</creatorcontrib><description>Patients with multiple sclerosis who develop progressive disability from onset without relapses or remissions pose difficulties in diagnosis, monitoring of disease activity and treatment. There is a need to define the diagnostic criteria for this group more precisely and, in particular, to describe a comprehensive battery of investigations to exclude other conditions. The mechanisms underlying the development of disability and the role of MRI in monitoring disease activity in this clinical subgroup require elucidation, particularly in view of the lack of change on conventional imaging in the presence of continuing clinical deterioration. The prognosis is poor and there are currently no treatment trials for this form of the disease.</description><identifier>ISSN: 0006-8950</identifier><identifier>ISSN: 1460-2156</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/120.6.1085</identifier><identifier>PMID: 9217691</identifier><identifier>CODEN: BRAIAK</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Biological and medical sciences ; Disease Progression ; Humans ; Medical sciences ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - genetics ; Multiple Sclerosis - physiopathology ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; Neurology ; Recurrence</subject><ispartof>Brain (London, England : 1878), 1997-06, Vol.120 (6), p.1085-1096</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright Oxford University Press Jun 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-df3d3c4950dc2ee787f8c94d40217dda4f7d897d9633e99c47a71e5905109ffe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2702708$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9217691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>THOMPSON, A. J</creatorcontrib><creatorcontrib>POLMAN, C. H</creatorcontrib><creatorcontrib>MILLER, D. H</creatorcontrib><creatorcontrib>MCDONALD, W. I</creatorcontrib><creatorcontrib>BROCHET, B</creatorcontrib><creatorcontrib>FILIPPI, M</creatorcontrib><creatorcontrib>MONTALBAN, X</creatorcontrib><creatorcontrib>DE SA, J</creatorcontrib><title>Primary progressive multiple sclerosis</title><title>Brain (London, England : 1878)</title><addtitle>Brain</addtitle><description>Patients with multiple sclerosis who develop progressive disability from onset without relapses or remissions pose difficulties in diagnosis, monitoring of disease activity and treatment. There is a need to define the diagnostic criteria for this group more precisely and, in particular, to describe a comprehensive battery of investigations to exclude other conditions. The mechanisms underlying the development of disability and the role of MRI in monitoring disease activity in this clinical subgroup require elucidation, particularly in view of the lack of change on conventional imaging in the presence of continuing clinical deterioration. The prognosis is poor and there are currently no treatment trials for this form of the disease.</description><subject>Biological and medical sciences</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple Sclerosis - genetics</subject><subject>Multiple Sclerosis - physiopathology</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>Neurology</subject><subject>Recurrence</subject><issn>0006-8950</issn><issn>1460-2156</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEQgIMotVbvXoQi0tu2M8luHkcpvqCgBz2HNMnKln3UpCv4703t4sGLEBjIfPP6CLlEmCMotlgHU7ULpDDn6UMWR2SMOYeMYsGPyRgAeCZVAafkLMYNAOaM8hEZKYqCKxyT2UuoGhO-ptvQvQcfY_Xpp01f76pt7afR1j50sYrn5KQ0dfQXQ5yQt_u71-Vjtnp-eFrerjLLJO4yVzLHbJ4GOku9F1KU0qrc5ZDmOWfyUjiphFOcMa-UzYUR6AsFRbqmLD2bkNmhb1rno_dxp5sqWl_XpvVdH7VQiAol_RekwDGtJBJ4_QfcdH1o0xEaVZEzQMkSBAfIpmtj8KXeHrRoBL0XrX9E6yRac70XnUquhr79uvHut2Awm_I3Q95Ea-oymNZW8RejAtKT7Bvex4Uf</recordid><startdate>19970601</startdate><enddate>19970601</enddate><creator>THOMPSON, A. J</creator><creator>POLMAN, C. H</creator><creator>MILLER, D. H</creator><creator>MCDONALD, W. I</creator><creator>BROCHET, B</creator><creator>FILIPPI, M</creator><creator>MONTALBAN, X</creator><creator>DE SA, J</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19970601</creationdate><title>Primary progressive multiple sclerosis</title><author>THOMPSON, A. J ; POLMAN, C. H ; MILLER, D. H ; MCDONALD, W. I ; BROCHET, B ; FILIPPI, M ; MONTALBAN, X ; DE SA, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-df3d3c4950dc2ee787f8c94d40217dda4f7d897d9633e99c47a71e5905109ffe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological and medical sciences</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple Sclerosis - genetics</topic><topic>Multiple Sclerosis - physiopathology</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>Neurology</topic><topic>Recurrence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THOMPSON, A. J</creatorcontrib><creatorcontrib>POLMAN, C. H</creatorcontrib><creatorcontrib>MILLER, D. H</creatorcontrib><creatorcontrib>MCDONALD, W. I</creatorcontrib><creatorcontrib>BROCHET, B</creatorcontrib><creatorcontrib>FILIPPI, M</creatorcontrib><creatorcontrib>MONTALBAN, X</creatorcontrib><creatorcontrib>DE SA, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain (London, England : 1878)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THOMPSON, A. J</au><au>POLMAN, C. H</au><au>MILLER, D. H</au><au>MCDONALD, W. I</au><au>BROCHET, B</au><au>FILIPPI, M</au><au>MONTALBAN, X</au><au>DE SA, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary progressive multiple sclerosis</atitle><jtitle>Brain (London, England : 1878)</jtitle><addtitle>Brain</addtitle><date>1997-06-01</date><risdate>1997</risdate><volume>120</volume><issue>6</issue><spage>1085</spage><epage>1096</epage><pages>1085-1096</pages><issn>0006-8950</issn><issn>1460-2156</issn><eissn>1460-2156</eissn><coden>BRAIAK</coden><abstract>Patients with multiple sclerosis who develop progressive disability from onset without relapses or remissions pose difficulties in diagnosis, monitoring of disease activity and treatment. There is a need to define the diagnostic criteria for this group more precisely and, in particular, to describe a comprehensive battery of investigations to exclude other conditions. The mechanisms underlying the development of disability and the role of MRI in monitoring disease activity in this clinical subgroup require elucidation, particularly in view of the lack of change on conventional imaging in the presence of continuing clinical deterioration. The prognosis is poor and there are currently no treatment trials for this form of the disease.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>9217691</pmid><doi>10.1093/brain/120.6.1085</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-8950 |
| ispartof | Brain (London, England : 1878), 1997-06, Vol.120 (6), p.1085-1096 |
| issn | 0006-8950 1460-2156 1460-2156 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79119182 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Biological and medical sciences Disease Progression Humans Medical sciences Multiple Sclerosis - diagnosis Multiple Sclerosis - genetics Multiple Sclerosis - physiopathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Recurrence |
| title | Primary progressive multiple sclerosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T17%3A44%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Primary%20progressive%20multiple%20sclerosis&rft.jtitle=Brain%20(London,%20England%20:%201878)&rft.au=THOMPSON,%20A.%20J&rft.date=1997-06-01&rft.volume=120&rft.issue=6&rft.spage=1085&rft.epage=1096&rft.pages=1085-1096&rft.issn=0006-8950&rft.eissn=1460-2156&rft.coden=BRAIAK&rft_id=info:doi/10.1093/brain/120.6.1085&rft_dat=%3Cproquest_cross%3E79119182%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=195430183&rft_id=info:pmid/9217691&rfr_iscdi=true |