An Antibody Reactive with Domain 4 of the Platelet-derived Growth Factor β Receptor Allows BB Binding while Inhibiting Proliferation by Impairing Receptor Dimerization

A panel of murine monoclonal antibodies was generated against the extracellular domain of the human platelet-derived growth factor (PDGF) β receptor (PDGFRβ). These antibodies were assayed for both the ability to inhibit binding of PDGF BB to PDGFRβ+ cells as well as the capacity to inhibit PDGF BB-...

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Veröffentlicht in:	The Journal of biological chemistry 1997-07, Vol.272 (28), p.17400-17404
Hauptverfasser:	Shulman, Theodore, Sauer, Frederic G., Jackman, Robin M., Chang, Chung Nan, Landolfi, Nicholas F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Becaplermin Binding Sites - immunology Cell Division CHO Cells Cricetinae Dimerization Epitope Mapping Humans Mice Platelet-Derived Growth Factor - metabolism Proto-Oncogene Proteins c-sis Rabbits Receptor, Platelet-Derived Growth Factor beta Receptors, Platelet-Derived Growth Factor - immunology
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