Effect of chemical structure of hydrogels on the adhesion and phenotypic characteristics of human monocytes such as expression of galectins and other carbohydrate-binding sites
The reactivity of diverse immune aspects to the presence of synthetic polymers represents one of the most important aspects of implantable device biocompatibility. In this report, we show the effect of the chemical structure of a synthetic polymer support on monocyte adhesion and selected phenotypic...
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| Veröffentlicht in: | Biomaterials 1997-07, Vol.18 (14), p.1009-1014 |
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| container_title | Biomaterials |
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| creator | Smetana, Karel Lukáš, Jaromír Palečková, Věra Bartůňková, Jiřina Liu, Fu-Tong Vacík, Jiří Gabius, Hans-Joachim |
| description | The reactivity of diverse immune aspects to the presence of synthetic polymers represents one of the most important aspects of implantable device biocompatibility. In this report, we show the effect of the chemical structure of a synthetic polymer support on monocyte adhesion and selected phenotypic characteristics
in vitro as a model for the initial steps of non-self-recognition of an implant. The extent of monocyte adhesion was significantly influenced by the support chemistry. The highest level of monocyte adhesion was observed on a surface copolymer of 2-hydroxyethyl methacrylate with dimethyl aminoethyl methacrylate relative to results of experiments in which poly(2-hydroxyethyl methacrylate) or the copolymer of 2-hydroxyethyl methacrylate with the sodium salt of methacrylic acid was used. Cell adhesion to the polymers tested and to glass was accompanied by enhanced expression of the carbohydrate-binding sites tested for asialoglycoprotein β-galactosides such as galectins, β-
N-acetylgalactosamine, α-mannoside, specific lectin for heparin as well as the lymphokine-macrophage migration inhibitory factor in the monocytes tested. These results suggest the importance of monocyte adhesion to the biomaterial surface for their development into macrophages and further non-self-recognition of the implanted device. |
| doi_str_mv | 10.1016/S0142-9612(97)00037-9 |
| format | Article |
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in vitro as a model for the initial steps of non-self-recognition of an implant. The extent of monocyte adhesion was significantly influenced by the support chemistry. The highest level of monocyte adhesion was observed on a surface copolymer of 2-hydroxyethyl methacrylate with dimethyl aminoethyl methacrylate relative to results of experiments in which poly(2-hydroxyethyl methacrylate) or the copolymer of 2-hydroxyethyl methacrylate with the sodium salt of methacrylic acid was used. Cell adhesion to the polymers tested and to glass was accompanied by enhanced expression of the carbohydrate-binding sites tested for asialoglycoprotein β-galactosides such as galectins, β-
N-acetylgalactosamine, α-mannoside, specific lectin for heparin as well as the lymphokine-macrophage migration inhibitory factor in the monocytes tested. These results suggest the importance of monocyte adhesion to the biomaterial surface for their development into macrophages and further non-self-recognition of the implanted device.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(97)00037-9</identifier><identifier>PMID: 9212197</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Acetylgalactosamine - metabolism ; biocompatability ; Biocompatible Materials - chemistry ; Biocompatible Materials - metabolism ; Biological and medical sciences ; Cell Adhesion - physiology ; endogenous lectins ; galectins ; Gels ; Gene Expression Regulation - genetics ; Glass ; Heparin - metabolism ; Humans ; Immunohistochemistry ; Lectins - biosynthesis ; Lectins - genetics ; Macrophages ; Mannosides - metabolism ; Medical sciences ; Methacrylates - chemistry ; Methacrylates - metabolism ; Monocytes - cytology ; Monocytes - metabolism ; Phenotype ; Polymers ; Prostheses and Implants ; Structure-Activity Relationship ; Surface Properties ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments</subject><ispartof>Biomaterials, 1997-07, Vol.18 (14), p.1009-1014</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-7e0839ab98f6d6a82a7513aebcc473ffc39ff6f03e209afdaf8dee8a6a200713</citedby><cites>FETCH-LOGICAL-c389t-7e0839ab98f6d6a82a7513aebcc473ffc39ff6f03e209afdaf8dee8a6a200713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0142-9612(97)00037-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2714323$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9212197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smetana, Karel</creatorcontrib><creatorcontrib>Lukáš, Jaromír</creatorcontrib><creatorcontrib>Palečková, Věra</creatorcontrib><creatorcontrib>Bartůňková, Jiřina</creatorcontrib><creatorcontrib>Liu, Fu-Tong</creatorcontrib><creatorcontrib>Vacík, Jiří</creatorcontrib><creatorcontrib>Gabius, Hans-Joachim</creatorcontrib><title>Effect of chemical structure of hydrogels on the adhesion and phenotypic characteristics of human monocytes such as expression of galectins and other carbohydrate-binding sites</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>The reactivity of diverse immune aspects to the presence of synthetic polymers represents one of the most important aspects of implantable device biocompatibility. In this report, we show the effect of the chemical structure of a synthetic polymer support on monocyte adhesion and selected phenotypic characteristics
in vitro as a model for the initial steps of non-self-recognition of an implant. The extent of monocyte adhesion was significantly influenced by the support chemistry. The highest level of monocyte adhesion was observed on a surface copolymer of 2-hydroxyethyl methacrylate with dimethyl aminoethyl methacrylate relative to results of experiments in which poly(2-hydroxyethyl methacrylate) or the copolymer of 2-hydroxyethyl methacrylate with the sodium salt of methacrylic acid was used. Cell adhesion to the polymers tested and to glass was accompanied by enhanced expression of the carbohydrate-binding sites tested for asialoglycoprotein β-galactosides such as galectins, β-
N-acetylgalactosamine, α-mannoside, specific lectin for heparin as well as the lymphokine-macrophage migration inhibitory factor in the monocytes tested. These results suggest the importance of monocyte adhesion to the biomaterial surface for their development into macrophages and further non-self-recognition of the implanted device.</description><subject>Acetylgalactosamine - metabolism</subject><subject>biocompatability</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion - physiology</subject><subject>endogenous lectins</subject><subject>galectins</subject><subject>Gels</subject><subject>Gene Expression Regulation - genetics</subject><subject>Glass</subject><subject>Heparin - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lectins - biosynthesis</subject><subject>Lectins - genetics</subject><subject>Macrophages</subject><subject>Mannosides - metabolism</subject><subject>Medical sciences</subject><subject>Methacrylates - chemistry</subject><subject>Methacrylates - metabolism</subject><subject>Monocytes - cytology</subject><subject>Monocytes - metabolism</subject><subject>Phenotype</subject><subject>Polymers</subject><subject>Prostheses and Implants</subject><subject>Structure-Activity Relationship</subject><subject>Surface Properties</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxiMEKkvhESr5gBA9BOxkE8cnhKryR6rEgd6tiTPeGCX24nFQ9614RLzZ1V45WeP5fd-M5iuKG8E_CC7ajz-52FalakX1XslbznktS_Ws2IhOdmWjePO82FyQl8Urol8813xbXRVXqhKVUHJT_L23Fk1iwTIz4uwMTIxSXExaIh5_x8MQww4nYsGzNCKDYURyuQA_sP2IPqTD3pkshwgmYXSUnKFVu8zg2Rx8MIeExGgxIwNi-LSPSKtJpnYw5Q2cp9Ux5BmRGYh9OI6GhGXv_OD8jpHLJq-LFxYmwjfn97p4_HL_ePetfPjx9fvd54fS1J1KpUTe1Qp61dl2aKGrQDaiBuyN2craWlMra1vLa6y4AjuA7QbEDlqoOJeivi7enWz3MfxekJKeHRmcJvAYFtJSCdE2Lc9gcwJNDEQRrd5HN0M8aMH1MSi9BqWPKWgl9RqUVll3cx6w9DMOF9U5mdx_e-4D5VBsBG8cXbBKim1d1Rn7dMJyQvjHYdRkHHqDg4v5qnoI7j-L_APQ8rVF</recordid><startdate>19970701</startdate><enddate>19970701</enddate><creator>Smetana, Karel</creator><creator>Lukáš, Jaromír</creator><creator>Palečková, Věra</creator><creator>Bartůňková, Jiřina</creator><creator>Liu, Fu-Tong</creator><creator>Vacík, Jiří</creator><creator>Gabius, Hans-Joachim</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970701</creationdate><title>Effect of chemical structure of hydrogels on the adhesion and phenotypic characteristics of human monocytes such as expression of galectins and other carbohydrate-binding sites</title><author>Smetana, Karel ; Lukáš, Jaromír ; Palečková, Věra ; Bartůňková, Jiřina ; Liu, Fu-Tong ; Vacík, Jiří ; Gabius, Hans-Joachim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-7e0839ab98f6d6a82a7513aebcc473ffc39ff6f03e209afdaf8dee8a6a200713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acetylgalactosamine - metabolism</topic><topic>biocompatability</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion - physiology</topic><topic>endogenous lectins</topic><topic>galectins</topic><topic>Gels</topic><topic>Gene Expression Regulation - genetics</topic><topic>Glass</topic><topic>Heparin - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lectins - biosynthesis</topic><topic>Lectins - genetics</topic><topic>Macrophages</topic><topic>Mannosides - metabolism</topic><topic>Medical sciences</topic><topic>Methacrylates - chemistry</topic><topic>Methacrylates - metabolism</topic><topic>Monocytes - cytology</topic><topic>Monocytes - metabolism</topic><topic>Phenotype</topic><topic>Polymers</topic><topic>Prostheses and Implants</topic><topic>Structure-Activity Relationship</topic><topic>Surface Properties</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. Equipments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smetana, Karel</creatorcontrib><creatorcontrib>Lukáš, Jaromír</creatorcontrib><creatorcontrib>Palečková, Věra</creatorcontrib><creatorcontrib>Bartůňková, Jiřina</creatorcontrib><creatorcontrib>Liu, Fu-Tong</creatorcontrib><creatorcontrib>Vacík, Jiří</creatorcontrib><creatorcontrib>Gabius, Hans-Joachim</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smetana, Karel</au><au>Lukáš, Jaromír</au><au>Palečková, Věra</au><au>Bartůňková, Jiřina</au><au>Liu, Fu-Tong</au><au>Vacík, Jiří</au><au>Gabius, Hans-Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of chemical structure of hydrogels on the adhesion and phenotypic characteristics of human monocytes such as expression of galectins and other carbohydrate-binding sites</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>1997-07-01</date><risdate>1997</risdate><volume>18</volume><issue>14</issue><spage>1009</spage><epage>1014</epage><pages>1009-1014</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>The reactivity of diverse immune aspects to the presence of synthetic polymers represents one of the most important aspects of implantable device biocompatibility. In this report, we show the effect of the chemical structure of a synthetic polymer support on monocyte adhesion and selected phenotypic characteristics
in vitro as a model for the initial steps of non-self-recognition of an implant. The extent of monocyte adhesion was significantly influenced by the support chemistry. The highest level of monocyte adhesion was observed on a surface copolymer of 2-hydroxyethyl methacrylate with dimethyl aminoethyl methacrylate relative to results of experiments in which poly(2-hydroxyethyl methacrylate) or the copolymer of 2-hydroxyethyl methacrylate with the sodium salt of methacrylic acid was used. Cell adhesion to the polymers tested and to glass was accompanied by enhanced expression of the carbohydrate-binding sites tested for asialoglycoprotein β-galactosides such as galectins, β-
N-acetylgalactosamine, α-mannoside, specific lectin for heparin as well as the lymphokine-macrophage migration inhibitory factor in the monocytes tested. These results suggest the importance of monocyte adhesion to the biomaterial surface for their development into macrophages and further non-self-recognition of the implanted device.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9212197</pmid><doi>10.1016/S0142-9612(97)00037-9</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biomaterials, 1997-07, Vol.18 (14), p.1009-1014 |
| issn | 0142-9612 1878-5905 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Acetylgalactosamine - metabolism biocompatability Biocompatible Materials - chemistry Biocompatible Materials - metabolism Biological and medical sciences Cell Adhesion - physiology endogenous lectins galectins Gels Gene Expression Regulation - genetics Glass Heparin - metabolism Humans Immunohistochemistry Lectins - biosynthesis Lectins - genetics Macrophages Mannosides - metabolism Medical sciences Methacrylates - chemistry Methacrylates - metabolism Monocytes - cytology Monocytes - metabolism Phenotype Polymers Prostheses and Implants Structure-Activity Relationship Surface Properties Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments |
| title | Effect of chemical structure of hydrogels on the adhesion and phenotypic characteristics of human monocytes such as expression of galectins and other carbohydrate-binding sites |
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