Increased susceptibility to endotoxin shock in complement C3- and C4- deficient mice is corrected by C1 inhibitor replacement

Endotoxin shock is a life-threatening syndrome associated with a Gram-negative infection and mediated by a systemic inflammatory response. As a major effector of inflammation, the complement system has been implicated in both the pathogenesis and the protection from endotoxin shock. To clarify the r...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-07, Vol.159 (2), p.976-982
Hauptverfasser:	Fischer, MB, Prodeus, AP, Nicholson-Weller, A, Ma, M, Murrow, J, Reid, RR, Warren, HB, Lage, AL, Moore, FD, Jr, Rosen, FS, Carroll, MC
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Complement C1 Inactivator Proteins - genetics Complement C1 Inactivator Proteins - immunology Complement C1 Inhibitor Protein Complement C3 - deficiency Complement C3 - genetics Complement C3 - immunology Complement C4 - deficiency Complement C4 - genetics Complement C4 - immunology Disease Susceptibility Mice Mice, Mutant Strains Shock, Septic - genetics Shock, Septic - immunology
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