Codon usage determines translation rate in Escherichia coli

We wish to determine whether differences in translation rate are correlated with differences in codon usage or with differences in mRNA secondary structure. We therefore inserted a small DNA fragment in the lacZ gene either directly or flanked by a few frame-shifting bases, leaving the reading frame...

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Veröffentlicht in:	Journal of molecular biology 1989-05, Vol.207 (2), p.365-377
Hauptverfasser:	Sørensen, Michael A., Kurland, C.G., Pedersen, Steen
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - analysis Base Sequence Biological and medical sciences Codon Escherichia coli Escherichia coli - genetics Fundamental and applied biological sciences. Psychology Lac Operon Molecular and cellular biology Molecular genetics Molecular Sequence Data Nucleic Acid Conformation Protein Biosynthesis RNA, Bacterial - genetics RNA, Messenger - genetics Time Factors Translation. Translation factors. Protein processing
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