HATOMAMICIN (YL-0358M-A), A NEW ALKALOID ANTIBIOTIC: FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES
Hatomamicin, a new alkaloid antibiotic, was isolated from the culture filtrate of a strain of Saccharopolyspora. The antibiotic was extracted with EtOAc and purified by silica gel column chromatography. The free alkaloid was obtained as pale yellowish prisms from CH3CN solution. It exhibits antimicr...
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| Veröffentlicht in: | Journal of antibiotics 1989/07/25, Vol.42(7), pp.1043-1048 |
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| container_title | Journal of antibiotics |
| container_volume | 42 |
| creator | IMAI, HARUMITSU FUJITA, SHIGEO SUZUKI, KENICHI MORIOKA, MOTO TOKUNAGA, TATSUHIRO SHIMIZU, MINORU KADOTA, SHIGENOBU FURUYA, TOSHIO SAITO, TAKESHI |
| description | Hatomamicin, a new alkaloid antibiotic, was isolated from the culture filtrate of a strain of Saccharopolyspora. The antibiotic was extracted with EtOAc and purified by silica gel column chromatography. The free alkaloid was obtained as pale yellowish prisms from CH3CN solution. It exhibits antimicrobial activity against Gram-positive organisms. The apparent molecular formula of hatomamicin was determined to be C22H31NO5. The structure has been established by a combination of spectroscopic and X-ray crystallographic studies. |
| doi_str_mv | 10.7164/antibiotics.42.1043 |
| format | Article |
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The antibiotic was extracted with EtOAc and purified by silica gel column chromatography. The free alkaloid was obtained as pale yellowish prisms from CH3CN solution. It exhibits antimicrobial activity against Gram-positive organisms. The apparent molecular formula of hatomamicin was determined to be C22H31NO5. The structure has been established by a combination of spectroscopic and X-ray crystallographic studies.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.42.1043</identifier><identifier>PMID: 2753811</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Alkaloids - analysis ; Alkaloids - biosynthesis ; Alkaloids - isolation & purification ; Alkaloids - pharmacology ; Anti-Bacterial Agents - analysis ; Anti-Bacterial Agents - biosynthesis ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; antibiotic YL-0358M-A ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacteria - drug effects ; Bacteria - metabolism ; Biological and medical sciences ; Chromatography, Thin Layer ; Fermentation ; gram-positive bacteria ; hatomamicin ; Magnetic Resonance Spectroscopy ; Medical sciences ; Molecular Structure ; Pharmacology. Drug treatments ; Soil Microbiology ; Spectrophotometry, Infrared ; Tumor Cells, Cultured ; X-Ray Diffraction</subject><ispartof>The Journal of Antibiotics, 1989/07/25, Vol.42(7), pp.1043-1048</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c641t-6b1e22fdd0bcd25bdcb130401ad90ad701f3998f725a7b41fd6f1f4bb6714ad83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6793367$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2753811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>IMAI, HARUMITSU</creatorcontrib><creatorcontrib>FUJITA, SHIGEO</creatorcontrib><creatorcontrib>SUZUKI, KENICHI</creatorcontrib><creatorcontrib>MORIOKA, MOTO</creatorcontrib><creatorcontrib>TOKUNAGA, TATSUHIRO</creatorcontrib><creatorcontrib>SHIMIZU, MINORU</creatorcontrib><creatorcontrib>KADOTA, SHIGENOBU</creatorcontrib><creatorcontrib>FURUYA, TOSHIO</creatorcontrib><creatorcontrib>SAITO, TAKESHI</creatorcontrib><title>HATOMAMICIN (YL-0358M-A), A NEW ALKALOID ANTIBIOTIC: FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Hatomamicin, a new alkaloid antibiotic, was isolated from the culture filtrate of a strain of Saccharopolyspora. The antibiotic was extracted with EtOAc and purified by silica gel column chromatography. The free alkaloid was obtained as pale yellowish prisms from CH3CN solution. It exhibits antimicrobial activity against Gram-positive organisms. The apparent molecular formula of hatomamicin was determined to be C22H31NO5. The structure has been established by a combination of spectroscopic and X-ray crystallographic studies.</description><subject>Alkaloids - analysis</subject><subject>Alkaloids - biosynthesis</subject><subject>Alkaloids - isolation & purification</subject><subject>Alkaloids - pharmacology</subject><subject>Anti-Bacterial Agents - analysis</subject><subject>Anti-Bacterial Agents - biosynthesis</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>antibiotic YL-0358M-A</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - metabolism</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Thin Layer</subject><subject>Fermentation</subject><subject>gram-positive bacteria</subject><subject>hatomamicin</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacology. Drug treatments</subject><subject>Soil Microbiology</subject><subject>Spectrophotometry, Infrared</subject><subject>Tumor Cells, Cultured</subject><subject>X-Ray Diffraction</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EKkvhFyCkHBACqVk8tmM7vZk0pRbZpMpmhThFTuJAquxuG2cP_Huy2mjVG5eZkd4380Z6CL0HvBTA2VezG7uq249d7ZaMLAEz-gItQErwgfHwJVpgTMCXkuDX6I1zDxhTQYW8QBdEBFQCLNDTnSqylVrpSKfe51-Jj2kgV776cuUpL41_eir5oZJM33gqLfQ3nRU6uvZu43wVp4UqdJZeeXqdJfO4LvJNVGzyeMJvvAlPsu86Uol3n2f3cV7oeP0WvWpN7-y7uV-izW1cRHf-jPo1ZzD6vAJLSNs0uKobElRNXQHFDINpQmwagaGlYShbQQIjKgZtw1toWVVxAcw0kl6iT6e7j8P-6WDdWG47V9u-Nzu7P7hShACECP5fEAJKMGN4AukJrIe9c4Nty8eh25rhbwm4PCZSPkukZKQ8JjJtfZjPH6qtbc47cwST_nHWjatN3w5mV3fujHERUsrFhCUn7MGN5rc962aY3Hr73BpCLo_24lSOX5yx-o8ZSruj_wAlhqhn</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>IMAI, HARUMITSU</creator><creator>FUJITA, SHIGEO</creator><creator>SUZUKI, KENICHI</creator><creator>MORIOKA, MOTO</creator><creator>TOKUNAGA, TATSUHIRO</creator><creator>SHIMIZU, MINORU</creator><creator>KADOTA, SHIGENOBU</creator><creator>FURUYA, TOSHIO</creator><creator>SAITO, TAKESHI</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>HATOMAMICIN (YL-0358M-A), A NEW ALKALOID ANTIBIOTIC: FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES</title><author>IMAI, HARUMITSU ; FUJITA, SHIGEO ; SUZUKI, KENICHI ; MORIOKA, MOTO ; TOKUNAGA, TATSUHIRO ; SHIMIZU, MINORU ; KADOTA, SHIGENOBU ; FURUYA, TOSHIO ; SAITO, TAKESHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c641t-6b1e22fdd0bcd25bdcb130401ad90ad701f3998f725a7b41fd6f1f4bb6714ad83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Alkaloids - analysis</topic><topic>Alkaloids - biosynthesis</topic><topic>Alkaloids - isolation & purification</topic><topic>Alkaloids - pharmacology</topic><topic>Anti-Bacterial Agents - analysis</topic><topic>Anti-Bacterial Agents - biosynthesis</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>antibiotic YL-0358M-A</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - metabolism</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Thin Layer</topic><topic>Fermentation</topic><topic>gram-positive bacteria</topic><topic>hatomamicin</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Pharmacology. 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Antibiot.</addtitle><date>1989</date><risdate>1989</risdate><volume>42</volume><issue>7</issue><spage>1043</spage><epage>1048</epage><pages>1043-1048</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Hatomamicin, a new alkaloid antibiotic, was isolated from the culture filtrate of a strain of Saccharopolyspora. The antibiotic was extracted with EtOAc and purified by silica gel column chromatography. The free alkaloid was obtained as pale yellowish prisms from CH3CN solution. It exhibits antimicrobial activity against Gram-positive organisms. The apparent molecular formula of hatomamicin was determined to be C22H31NO5. The structure has been established by a combination of spectroscopic and X-ray crystallographic studies.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>2753811</pmid><doi>10.7164/antibiotics.42.1043</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1989/07/25, Vol.42(7), pp.1043-1048 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | J-STAGE Free; MEDLINE |
| subjects | Alkaloids - analysis Alkaloids - biosynthesis Alkaloids - isolation & purification Alkaloids - pharmacology Anti-Bacterial Agents - analysis Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial agents antibiotic YL-0358M-A Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Bacteria - metabolism Biological and medical sciences Chromatography, Thin Layer Fermentation gram-positive bacteria hatomamicin Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Pharmacology. Drug treatments Soil Microbiology Spectrophotometry, Infrared Tumor Cells, Cultured X-Ray Diffraction |
| title | HATOMAMICIN (YL-0358M-A), A NEW ALKALOID ANTIBIOTIC: FERMENTATION, ISOLATION, STRUCTURE AND BIOLOGICAL PROPERTIES |
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