Full-term birth weight and placental morphology at high and low altitude
Objective: To study the association between placental morphology and full-term birth weight at high and low altitude. Subjects: Twenty normal pregnant women living permanently at high altitude (3100 m) and 20 normal pregnant women living permanently at low altitude (500 m) in Southern Saudi Arabia....
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| Veröffentlicht in: | International journal of gynecology and obstetrics 1997-06, Vol.57 (3), p.259-265 |
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| container_title | International journal of gynecology and obstetrics |
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| creator | Khalid, M.E.M. Ali, M.E. Ali, K.Z.M. |
| description | Objective: To study the association between placental morphology and full-term birth weight at high and low altitude.
Subjects: Twenty normal pregnant women living permanently at high altitude (3100 m) and 20 normal pregnant women living permanently at low altitude (500 m) in Southern Saudi Arabia.
Method: For each subject in the two groups the mean hemoglobin concentration and hematocrit values throughout pregnancy were estimated and these were used as indices for maternal hypoxia. After delivery, the birth weight of each fetus was determined together with the placental weight. Placentas were then examined histologically using sections stained by periodic acid-Schiff and hematoxylin-eosin. The mean percentages of villi with syncytial knots, cytotrophoblastic cells and fetal capillaries were determined.
Results: The mean hemoglobin concentration and hematocrit values were significantly greater at high altitude than at low altitude (
P < 0.001 for both). The mean birth weight and placental weight were significantly greater at low altitude compared to high altitude (
P < 0.025 and 0.001, respectively). The placentas from high altitude showed histological changes suggestive of placental hypoxia i.e. significant increase in the incidence of syncytial knots, cytotrophoblastic cells and fetal capillaries at high altitude compared to low altitude (
P < 0.005, 0.001 and |
| doi_str_mv | 10.1016/S0020-7292(97)00067-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79111664</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0020729297000672</els_id><sourcerecordid>79111664</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4409-2be8a0dfd85a9c34fb9f49779d0e6775ab6cac6d7fd42d27e62593ca8af2f6b43</originalsourceid><addsrcrecordid>eNqNkE1v1DAQhi1EVZaFn1ApB4TgEGo7iR1zqVBFv1Sph8LZmtjjrpGTLLbDav892Q_tFU5zeJ93RvMQcsHoF0aZuHymlNNScsU_KfmZUipkyV-RBWulKqtaqtdkcULekLcp_ZohJhk7J-eKs6Zu2wW5u5lCKDPGvuh8zKtig_5llQsYbLEOYHDIEIp-jOvVGMaXbQG5WM3EHgjjpoCQfZ4sviNnDkLC98e5JD9vvv-4visfn27vr789lqauqSp5hy1Q62zbgDJV7TrlaiWlshSFlA10woARVjpbc8slCt6oykALjjvR1dWSfDzsXcfx94Qp694ngyHAgOOUtFSMMSF2YHMATRxTiuj0Ovoe4lYzqncG9d6g3unRSuq9Qc3n3sXxwNT1aE-to7I5_3DMIRkILsJgfDphXFJZMTZjXw_Yxgfc_t9tff9w-7T7d0muDmWcTf7xGHUyHgeD1kc0WdvR_-OLv41Fni0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79111664</pqid></control><display><type>article</type><title>Full-term birth weight and placental morphology at high and low altitude</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Khalid, M.E.M. ; Ali, M.E. ; Ali, K.Z.M.</creator><creatorcontrib>Khalid, M.E.M. ; Ali, M.E. ; Ali, K.Z.M.</creatorcontrib><description><![CDATA[Objective: To study the association between placental morphology and full-term birth weight at high and low altitude.
Subjects: Twenty normal pregnant women living permanently at high altitude (3100 m) and 20 normal pregnant women living permanently at low altitude (500 m) in Southern Saudi Arabia.
Method: For each subject in the two groups the mean hemoglobin concentration and hematocrit values throughout pregnancy were estimated and these were used as indices for maternal hypoxia. After delivery, the birth weight of each fetus was determined together with the placental weight. Placentas were then examined histologically using sections stained by periodic acid-Schiff and hematoxylin-eosin. The mean percentages of villi with syncytial knots, cytotrophoblastic cells and fetal capillaries were determined.
Results: The mean hemoglobin concentration and hematocrit values were significantly greater at high altitude than at low altitude (
P < 0.001 for both). The mean birth weight and placental weight were significantly greater at low altitude compared to high altitude (
P < 0.025 and 0.001, respectively). The placentas from high altitude showed histological changes suggestive of placental hypoxia i.e. significant increase in the incidence of syncytial knots, cytotrophoblastic cells and fetal capillaries at high altitude compared to low altitude (
P < 0.005, 0.001 and <0.05, respectively). At both high and low altitude the incidences of syncytial knots and cytotrophoblastic cells showed positive and significant correlations with mean maternal hemoglobin (
r = 0.5 and 0.6,
P < 0.01 and <0.001, respectively) and hematocrit (
r = 0.5 and 0.6,
P < 0.01 and 0.001, respectively) during pregnancy and negative and significant correlations with fetal birth weight (
r = −0.4 and −0.6,
P < 0.01 and
P < 0.001, respectively).
Conclusion: The low birth weight observed at high altitude compared to low altitude appeared to be mainly secondary to placental hypoxia resulting from maternal hypoxia which in turn was caused by high altitude hypoxia.]]></description><identifier>ISSN: 0020-7292</identifier><identifier>EISSN: 1879-3479</identifier><identifier>DOI: 10.1016/S0020-7292(97)00067-2</identifier><identifier>PMID: 9215488</identifier><identifier>CODEN: IJGOAL</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Altitude ; Altitude Sickness - complications ; Biological and medical sciences ; Birth Weight ; Cell Hypoxia ; Delivery. Postpartum. Lactation ; Female ; Gynecology. Andrology. Obstetrics ; Hematocrit ; Hemoglobins - analysis ; Humans ; Hypoxia - complications ; Infant, Low Birth Weight ; Infant, Newborn ; Maternal, fetal and perinatal monitoring ; Medical sciences ; Placenta ; Placenta - anatomy & histology ; Pregnancy - blood ; Pregnancy Complications ; Tropical medicine</subject><ispartof>International journal of gynecology and obstetrics, 1997-06, Vol.57 (3), p.259-265</ispartof><rights>1997</rights><rights>1997 International Federation of Gynecology and Obstetrics</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4409-2be8a0dfd85a9c34fb9f49779d0e6775ab6cac6d7fd42d27e62593ca8af2f6b43</citedby><cites>FETCH-LOGICAL-c4409-2be8a0dfd85a9c34fb9f49779d0e6775ab6cac6d7fd42d27e62593ca8af2f6b43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2FS0020-7292%2897%2900067-2$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0020729297000672$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,1411,3537,27901,27902,45550,45551,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2707311$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9215488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khalid, M.E.M.</creatorcontrib><creatorcontrib>Ali, M.E.</creatorcontrib><creatorcontrib>Ali, K.Z.M.</creatorcontrib><title>Full-term birth weight and placental morphology at high and low altitude</title><title>International journal of gynecology and obstetrics</title><addtitle>Int J Gynaecol Obstet</addtitle><description><![CDATA[Objective: To study the association between placental morphology and full-term birth weight at high and low altitude.
Subjects: Twenty normal pregnant women living permanently at high altitude (3100 m) and 20 normal pregnant women living permanently at low altitude (500 m) in Southern Saudi Arabia.
Method: For each subject in the two groups the mean hemoglobin concentration and hematocrit values throughout pregnancy were estimated and these were used as indices for maternal hypoxia. After delivery, the birth weight of each fetus was determined together with the placental weight. Placentas were then examined histologically using sections stained by periodic acid-Schiff and hematoxylin-eosin. The mean percentages of villi with syncytial knots, cytotrophoblastic cells and fetal capillaries were determined.
Results: The mean hemoglobin concentration and hematocrit values were significantly greater at high altitude than at low altitude (
P < 0.001 for both). The mean birth weight and placental weight were significantly greater at low altitude compared to high altitude (
P < 0.025 and 0.001, respectively). The placentas from high altitude showed histological changes suggestive of placental hypoxia i.e. significant increase in the incidence of syncytial knots, cytotrophoblastic cells and fetal capillaries at high altitude compared to low altitude (
P < 0.005, 0.001 and <0.05, respectively). At both high and low altitude the incidences of syncytial knots and cytotrophoblastic cells showed positive and significant correlations with mean maternal hemoglobin (
r = 0.5 and 0.6,
P < 0.01 and <0.001, respectively) and hematocrit (
r = 0.5 and 0.6,
P < 0.01 and 0.001, respectively) during pregnancy and negative and significant correlations with fetal birth weight (
r = −0.4 and −0.6,
P < 0.01 and
P < 0.001, respectively).
Conclusion: The low birth weight observed at high altitude compared to low altitude appeared to be mainly secondary to placental hypoxia resulting from maternal hypoxia which in turn was caused by high altitude hypoxia.]]></description><subject>Altitude</subject><subject>Altitude Sickness - complications</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Cell Hypoxia</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hematocrit</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Hypoxia - complications</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Maternal, fetal and perinatal monitoring</subject><subject>Medical sciences</subject><subject>Placenta</subject><subject>Placenta - anatomy & histology</subject><subject>Pregnancy - blood</subject><subject>Pregnancy Complications</subject><subject>Tropical medicine</subject><issn>0020-7292</issn><issn>1879-3479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi1EVZaFn1ApB4TgEGo7iR1zqVBFv1Sph8LZmtjjrpGTLLbDav892Q_tFU5zeJ93RvMQcsHoF0aZuHymlNNScsU_KfmZUipkyV-RBWulKqtaqtdkcULekLcp_ZohJhk7J-eKs6Zu2wW5u5lCKDPGvuh8zKtig_5llQsYbLEOYHDIEIp-jOvVGMaXbQG5WM3EHgjjpoCQfZ4sviNnDkLC98e5JD9vvv-4visfn27vr789lqauqSp5hy1Q62zbgDJV7TrlaiWlshSFlA10woARVjpbc8slCt6oykALjjvR1dWSfDzsXcfx94Qp694ngyHAgOOUtFSMMSF2YHMATRxTiuj0Ovoe4lYzqncG9d6g3unRSuq9Qc3n3sXxwNT1aE-to7I5_3DMIRkILsJgfDphXFJZMTZjXw_Yxgfc_t9tff9w-7T7d0muDmWcTf7xGHUyHgeD1kc0WdvR_-OLv41Fni0</recordid><startdate>199706</startdate><enddate>199706</enddate><creator>Khalid, M.E.M.</creator><creator>Ali, M.E.</creator><creator>Ali, K.Z.M.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199706</creationdate><title>Full-term birth weight and placental morphology at high and low altitude</title><author>Khalid, M.E.M. ; Ali, M.E. ; Ali, K.Z.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4409-2be8a0dfd85a9c34fb9f49779d0e6775ab6cac6d7fd42d27e62593ca8af2f6b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Altitude</topic><topic>Altitude Sickness - complications</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>Cell Hypoxia</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hematocrit</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Hypoxia - complications</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Maternal, fetal and perinatal monitoring</topic><topic>Medical sciences</topic><topic>Placenta</topic><topic>Placenta - anatomy & histology</topic><topic>Pregnancy - blood</topic><topic>Pregnancy Complications</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khalid, M.E.M.</creatorcontrib><creatorcontrib>Ali, M.E.</creatorcontrib><creatorcontrib>Ali, K.Z.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khalid, M.E.M.</au><au>Ali, M.E.</au><au>Ali, K.Z.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Full-term birth weight and placental morphology at high and low altitude</atitle><jtitle>International journal of gynecology and obstetrics</jtitle><addtitle>Int J Gynaecol Obstet</addtitle><date>1997-06</date><risdate>1997</risdate><volume>57</volume><issue>3</issue><spage>259</spage><epage>265</epage><pages>259-265</pages><issn>0020-7292</issn><eissn>1879-3479</eissn><coden>IJGOAL</coden><abstract><![CDATA[Objective: To study the association between placental morphology and full-term birth weight at high and low altitude.
Subjects: Twenty normal pregnant women living permanently at high altitude (3100 m) and 20 normal pregnant women living permanently at low altitude (500 m) in Southern Saudi Arabia.
Method: For each subject in the two groups the mean hemoglobin concentration and hematocrit values throughout pregnancy were estimated and these were used as indices for maternal hypoxia. After delivery, the birth weight of each fetus was determined together with the placental weight. Placentas were then examined histologically using sections stained by periodic acid-Schiff and hematoxylin-eosin. The mean percentages of villi with syncytial knots, cytotrophoblastic cells and fetal capillaries were determined.
Results: The mean hemoglobin concentration and hematocrit values were significantly greater at high altitude than at low altitude (
P < 0.001 for both). The mean birth weight and placental weight were significantly greater at low altitude compared to high altitude (
P < 0.025 and 0.001, respectively). The placentas from high altitude showed histological changes suggestive of placental hypoxia i.e. significant increase in the incidence of syncytial knots, cytotrophoblastic cells and fetal capillaries at high altitude compared to low altitude (
P < 0.005, 0.001 and <0.05, respectively). At both high and low altitude the incidences of syncytial knots and cytotrophoblastic cells showed positive and significant correlations with mean maternal hemoglobin (
r = 0.5 and 0.6,
P < 0.01 and <0.001, respectively) and hematocrit (
r = 0.5 and 0.6,
P < 0.01 and 0.001, respectively) during pregnancy and negative and significant correlations with fetal birth weight (
r = −0.4 and −0.6,
P < 0.01 and
P < 0.001, respectively).
Conclusion: The low birth weight observed at high altitude compared to low altitude appeared to be mainly secondary to placental hypoxia resulting from maternal hypoxia which in turn was caused by high altitude hypoxia.]]></abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9215488</pmid><doi>10.1016/S0020-7292(97)00067-2</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0020-7292 |
| ispartof | International journal of gynecology and obstetrics, 1997-06, Vol.57 (3), p.259-265 |
| issn | 0020-7292 1879-3479 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79111664 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present); Wiley Online Library Journals Frontfile Complete |
| subjects | Altitude Altitude Sickness - complications Biological and medical sciences Birth Weight Cell Hypoxia Delivery. Postpartum. Lactation Female Gynecology. Andrology. Obstetrics Hematocrit Hemoglobins - analysis Humans Hypoxia - complications Infant, Low Birth Weight Infant, Newborn Maternal, fetal and perinatal monitoring Medical sciences Placenta Placenta - anatomy & histology Pregnancy - blood Pregnancy Complications Tropical medicine |
| title | Full-term birth weight and placental morphology at high and low altitude |
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