The administration of complement component C9 enhances the survival of neonatal rats with Escherichia coli sepsis

To determine the significance of neonatal C9 deficiency, an animal model was developed in the rat. By rocket immunoelectrophoresis, the concentration of C9 in pooled adult rat serum was 224 +/- 7.2 microg/mL. In contrast, the concentration of C9 in pooled serum from 1-d-old rats was only 43 +/- 3.8...

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Veröffentlicht in:	Pediatric research 1997-07, Vol.42 (1), p.128-136
Hauptverfasser:	LASSITER, H. A, WALZ, B. M, WILSON, J. L, JUNG, E, CALISI, C. R, GOLDSMITH, L. J, WILSON, R. A, MORGAN, B. P, FELDHOFF, R. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Newborn Bacteremia - immunology Bacteremia - therapy Bacterial diseases Bacterial sepsis Biological and medical sciences Blood Bactericidal Activity Complement C9 - administration & dosage Complement C9 - deficiency Disease Models, Animal Escherichia coli Infections - immunology Escherichia coli Infections - therapy Hemolysis Human bacterial diseases Humans Immunoglobulin G - administration & dosage Immunoglobulins, Intravenous - therapeutic use In Vitro Techniques Infectious diseases Injections, Intraperitoneal Medical sciences Rats Rats, Sprague-Dawley Sepsis - immunology Sepsis - therapy
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