Von Willebrand factor restores impaired platelet thrombogenesis in copper-deficient rats

Dietary copper restriction reduces microvascular thrombogenesis. We have now examined the roles of shear forces and von Willebrand factor (vWF) in in vivo thrombus formation in the cremaster microcirculation of copper-deficient rats. Male weanling Sprague-Dawley rats were fed purified diets that wer...

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Veröffentlicht in:	The Journal of nutrition 1997-07, Vol.127 (7), p.1320-1327
Hauptverfasser:	Lominadze, David, Saari, Jack T, Miller, Frederick N, Catalfamo, James L, Schuschke, Dale A
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance animal models Animals arteries Arterioles - cytology Arterioles - physiology Biological and medical sciences Blood blood coagulation factors blood plasma blood platelets Blood Platelets - cytology Blood Platelets - drug effects Blood Platelets - physiology blood pressure Blood Pressure - physiology Blood Viscosity - physiology body weight Body Weight - physiology Cell Adhesion - drug effects Cell Adhesion - physiology Circulatory system Copper Copper - analysis Copper - deficiency Copper - physiology diet duration Endothelium, Vascular - cytology Endothelium, Vascular - physiology experimental diets heart rate Heart Rate - physiology Hematocrit Iron - analysis liver Liver - chemistry Male Medical sciences Metabolic diseases nutrient deficiencies Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Rats Rats, Sprague-Dawley Regional Blood Flow Rodents shear thrombosis Thrombosis - blood Thrombosis - etiology Thrombosis - physiopathology trace element deficiencies veins viscosity von Willebrand Factor - pharmacology
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