Longitudinal Changes in Pulmonary Function Following Bone Marrow Transplantation
We prospectively followed a well characterized cohort of patients post-bone marrow transplantation for changes in pulmonary function. Thirty-four recipients without respiratory symptoms were available for follow up with a mean of two years. Spirometry and other measures of lung volume were well pres...
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| Veröffentlicht in: | Chest 1989-08, Vol.96 (2), p.301-306 |
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| creator | Prince, David S. Wingard, John R. Saral, Rein Santos, George W. Wise, Robert A. |
| description | We prospectively followed a well characterized cohort of patients post-bone marrow transplantation for changes in pulmonary function. Thirty-four recipients without respiratory symptoms were available for follow up with a mean of two years. Spirometry and other measures of lung volume were well preserved following bone marrow transplantation. A progressive 11.9 percent decline in percent predicted diffusing capacity per year occurred. Age, cigarette smoking, type of cytoreductive therapy, type of GVHD prophylaxis, and the occurrence of AGVHD did not affect longitudinal changes in pulmonary function. Patients receiving transplants for CML developed a highly significant fall in diffusing capacity. Asymptomatic patients with CGVHD developed evidence of progressive obstructive ventilatory impairment. This suggests a subclinical spectrum of patients who may progress to the development of bronchiolitis obliterans and respiratory failure post-bone marrow transplantation. (Chest 1989; 96:301–06) |
| doi_str_mv | 10.1378/chest.96.2.301 |
| format | Article |
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Thirty-four recipients without respiratory symptoms were available for follow up with a mean of two years. Spirometry and other measures of lung volume were well preserved following bone marrow transplantation. A progressive 11.9 percent decline in percent predicted diffusing capacity per year occurred. Age, cigarette smoking, type of cytoreductive therapy, type of GVHD prophylaxis, and the occurrence of AGVHD did not affect longitudinal changes in pulmonary function. Patients receiving transplants for CML developed a highly significant fall in diffusing capacity. Asymptomatic patients with CGVHD developed evidence of progressive obstructive ventilatory impairment. This suggests a subclinical spectrum of patients who may progress to the development of bronchiolitis obliterans and respiratory failure post-bone marrow transplantation. (Chest 1989; 96:301–06)</description><identifier>ISSN: 0012-3692</identifier><identifier>EISSN: 1931-3543</identifier><identifier>DOI: 10.1378/chest.96.2.301</identifier><identifier>PMID: 2666044</identifier><identifier>CODEN: CHETBF</identifier><language>eng</language><publisher>Northbrook, IL: Elsevier Inc</publisher><subject>Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone Marrow Transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Cohort Studies ; Female ; Graft vs Host Disease - prevention & control ; Humans ; Immunosuppressive Agents - therapeutic use ; Lung Diseases - etiology ; Lung Volume Measurements ; Male ; Medical sciences ; Middle Aged ; Prospective Studies ; Pulmonary Diffusing Capacity ; Smoking ; Spirometry ; Time Factors ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Chest, 1989-08, Vol.96 (2), p.301-306</ispartof><rights>1989 The American College of Chest Physicians</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-2e2c3bb9574ddc14fe4c1cf622b2868ac7f5dc8012ca41b92c7f6bae6314f4a83</citedby><cites>FETCH-LOGICAL-c407t-2e2c3bb9574ddc14fe4c1cf622b2868ac7f5dc8012ca41b92c7f6bae6314f4a83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7298303$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2666044$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prince, David S.</creatorcontrib><creatorcontrib>Wingard, John R.</creatorcontrib><creatorcontrib>Saral, Rein</creatorcontrib><creatorcontrib>Santos, George W.</creatorcontrib><creatorcontrib>Wise, Robert A.</creatorcontrib><title>Longitudinal Changes in Pulmonary Function Following Bone Marrow Transplantation</title><title>Chest</title><addtitle>Chest</addtitle><description>We prospectively followed a well characterized cohort of patients post-bone marrow transplantation for changes in pulmonary function. Thirty-four recipients without respiratory symptoms were available for follow up with a mean of two years. Spirometry and other measures of lung volume were well preserved following bone marrow transplantation. A progressive 11.9 percent decline in percent predicted diffusing capacity per year occurred. Age, cigarette smoking, type of cytoreductive therapy, type of GVHD prophylaxis, and the occurrence of AGVHD did not affect longitudinal changes in pulmonary function. Patients receiving transplants for CML developed a highly significant fall in diffusing capacity. Asymptomatic patients with CGVHD developed evidence of progressive obstructive ventilatory impairment. This suggests a subclinical spectrum of patients who may progress to the development of bronchiolitis obliterans and respiratory failure post-bone marrow transplantation. (Chest 1989; 96:301–06)</description><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Graft vs Host Disease - prevention & control</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Lung Diseases - etiology</subject><subject>Lung Volume Measurements</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Pulmonary Diffusing Capacity</subject><subject>Smoking</subject><subject>Spirometry</subject><subject>Time Factors</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0012-3692</issn><issn>1931-3543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1v2zAQxYmiQeqkXbsV0FB0k8IvU-LYGnUSwEU8ODNBnSibAUW6pBQj_32Y2Ei6dCKO9967ux9CXwmuCKubK9iZNFZSVLRimHxAMyIZKdmcs49ohjGhJROSfkIXKT3gXBMpztE5FUJgzmdovQp-a8eps167YrHTfmtSYX2xntwQvI5PxXLyMNrgi2VwLhys3xa_gjfFHx1jOBSbqH3aO-1H_aL6jM567ZL5cnov0f3y92ZxU67urm8XP1clcFyPJTUUWNvKec27DgjvDQcCvaC0pY1oNNT9vIMm7w-ak1bS_CFabQTLWq4bdol-HHP3MfydMgM12ATG5UVMmJKqJcF1U8-zsDoKIYaUounVPtohH6YIVi8I1StCJYWiKiPMhm-n5KkdTPcmPzHL_e-nvk6gXZ_vB5veZDWVDcPsfe7ObncHG41Kg3Yuh7LjxIcwxQz9n7nN0WAytkdrokpgjQfTZTOMqgv2fys_A5Kan70</recordid><startdate>19890801</startdate><enddate>19890801</enddate><creator>Prince, David S.</creator><creator>Wingard, John R.</creator><creator>Saral, Rein</creator><creator>Santos, George W.</creator><creator>Wise, Robert A.</creator><general>Elsevier Inc</general><general>American College of Chest Physicians</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890801</creationdate><title>Longitudinal Changes in Pulmonary Function Following Bone Marrow Transplantation</title><author>Prince, David S. ; Wingard, John R. ; Saral, Rein ; Santos, George W. ; Wise, Robert A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-2e2c3bb9574ddc14fe4c1cf622b2868ac7f5dc8012ca41b92c7f6bae6314f4a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Graft vs Host Disease - prevention & control</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Lung Diseases - etiology</topic><topic>Lung Volume Measurements</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Pulmonary Diffusing Capacity</topic><topic>Smoking</topic><topic>Spirometry</topic><topic>Time Factors</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prince, David S.</creatorcontrib><creatorcontrib>Wingard, John R.</creatorcontrib><creatorcontrib>Saral, Rein</creatorcontrib><creatorcontrib>Santos, George W.</creatorcontrib><creatorcontrib>Wise, Robert A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chest</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prince, David S.</au><au>Wingard, John R.</au><au>Saral, Rein</au><au>Santos, George W.</au><au>Wise, Robert A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Longitudinal Changes in Pulmonary Function Following Bone Marrow Transplantation</atitle><jtitle>Chest</jtitle><addtitle>Chest</addtitle><date>1989-08-01</date><risdate>1989</risdate><volume>96</volume><issue>2</issue><spage>301</spage><epage>306</epage><pages>301-306</pages><issn>0012-3692</issn><eissn>1931-3543</eissn><coden>CHETBF</coden><abstract>We prospectively followed a well characterized cohort of patients post-bone marrow transplantation for changes in pulmonary function. Thirty-four recipients without respiratory symptoms were available for follow up with a mean of two years. Spirometry and other measures of lung volume were well preserved following bone marrow transplantation. A progressive 11.9 percent decline in percent predicted diffusing capacity per year occurred. Age, cigarette smoking, type of cytoreductive therapy, type of GVHD prophylaxis, and the occurrence of AGVHD did not affect longitudinal changes in pulmonary function. Patients receiving transplants for CML developed a highly significant fall in diffusing capacity. Asymptomatic patients with CGVHD developed evidence of progressive obstructive ventilatory impairment. This suggests a subclinical spectrum of patients who may progress to the development of bronchiolitis obliterans and respiratory failure post-bone marrow transplantation. (Chest 1989; 96:301–06)</abstract><cop>Northbrook, IL</cop><pub>Elsevier Inc</pub><pmid>2666044</pmid><doi>10.1378/chest.96.2.301</doi><tpages>6</tpages></addata></record> |
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| ispartof | Chest, 1989-08, Vol.96 (2), p.301-306 |
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| subjects | Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Cohort Studies Female Graft vs Host Disease - prevention & control Humans Immunosuppressive Agents - therapeutic use Lung Diseases - etiology Lung Volume Measurements Male Medical sciences Middle Aged Prospective Studies Pulmonary Diffusing Capacity Smoking Spirometry Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Longitudinal Changes in Pulmonary Function Following Bone Marrow Transplantation |
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