Mast cells are closely apposed to nerves in the human gastrointestinal mucosa
Mast cell/nerve associations have been recorded in several publications; however, the human gastrointestinal tract has received little attention. Accordingly, mucosal samples from small bowel, appendix, and large bowel were studied. Combined histochemical/immunocytochemical techniques revealed that...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1989-09, Vol.97 (3), p.575-585 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
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| creator | Stead, Ron H. Dixon, Michael F. Bramwell, Nigel H. Riddell, Robert H. Bienenstock, John |
| description | Mast cell/nerve associations have been recorded in several publications; however, the human gastrointestinal tract has received little attention. Accordingly, mucosal samples from small bowel, appendix, and large bowel were studied. Combined histochemical/immunocytochemical techniques revealed that the proportion of mast cells apposed to nerves ranged from 47.08% ± 6.10% to 77.66% ± 4.26%. The highest incidence of contact was observed in the appendix; where the apparent nerve density was also greater than in the large or small bowel. Electron-microscopic studies revealed many mast cells adjacent to nerve fibers and membraneto-membrane contact between axonlike processes and mast cells. Often, these processes were dilated, as were axons in adjacent nerve fibers. These data provide a microanatomic basis for potential communication between nerves and mast cells in the human gastrointestinal mucosa. This may be of physiologic significance in the normal individual and important in disease processes, such as inflammation and fibrosis. |
| doi_str_mv | 10.1016/0016-5085(89)90627-6 |
| format | Article |
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This may be of physiologic significance in the normal individual and important in disease processes, such as inflammation and fibrosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Axons - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Cell interactions, adhesion</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Intestinal Mucosa - anatomy & histology</subject><subject>Male</subject><subject>Mast Cells - ultrastructure</subject><subject>Microscopy, Electron</subject><subject>Middle Aged</subject><subject>Molecular and cellular biology</subject><subject>Nerve Fibers - ultrastructure</subject><subject>Nerve Net - ultrastructure</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1q3DAURkVISabTvEECWpTSLtxIsiVLm0AJSVpI6CZdi2vpulHxz1SyB-btI2eGWWYjCb7zXa4OIZecfeeMq2uWj0IyLb9q880wJepCnZAVl0IXOROnZHVEzsnHlP4xxkyp-Rk5E0opIdmKPD1BmqjDrksUIlLXjQm7HYXNJj88nUY6YNxiomGg0wvSl7mHgf7NrTiGYcI0hQE62s9uTPCJfGihS3hxuNfkz_3d8-3P4vH3w6_bH4-Fq6SYCq5rySVUjfbga25a4ZXypjKicRrappS-lq7WgmGjoNUlA4NQKq8EYy3n5Zp82c_dxPH_nHewfUjLJ2DAcU62NpwpyVUGqz3o4phSxNZuYugh7ixndrFoF0V2UWS1sW8W7VK7Osyfmx79sXTQlvPPhxySg66NMLiQjlimDJfLmJs9htnFNmC0yQUcHPoQ0U3Wj-H9PV4BV-ONvg</recordid><startdate>19890901</startdate><enddate>19890901</enddate><creator>Stead, Ron H.</creator><creator>Dixon, Michael F.</creator><creator>Bramwell, Nigel H.</creator><creator>Riddell, Robert H.</creator><creator>Bienenstock, John</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890901</creationdate><title>Mast cells are closely apposed to nerves in the human gastrointestinal mucosa</title><author>Stead, Ron H. ; Dixon, Michael F. ; Bramwell, Nigel H. ; Riddell, Robert H. ; Bienenstock, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-187515a4b8dad719f2d66d9492bc8afb35d75c7820eb6af830a9ea36d6200f113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Axons - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Cell interactions, adhesion</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Intestinal Mucosa - anatomy & histology</topic><topic>Male</topic><topic>Mast Cells - ultrastructure</topic><topic>Microscopy, Electron</topic><topic>Middle Aged</topic><topic>Molecular and cellular biology</topic><topic>Nerve Fibers - ultrastructure</topic><topic>Nerve Net - ultrastructure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stead, Ron H.</creatorcontrib><creatorcontrib>Dixon, Michael F.</creatorcontrib><creatorcontrib>Bramwell, Nigel H.</creatorcontrib><creatorcontrib>Riddell, Robert H.</creatorcontrib><creatorcontrib>Bienenstock, John</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stead, Ron H.</au><au>Dixon, Michael F.</au><au>Bramwell, Nigel H.</au><au>Riddell, Robert H.</au><au>Bienenstock, John</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mast cells are closely apposed to nerves in the human gastrointestinal mucosa</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1989-09-01</date><risdate>1989</risdate><volume>97</volume><issue>3</issue><spage>575</spage><epage>585</epage><pages>575-585</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>Mast cell/nerve associations have been recorded in several publications; however, the human gastrointestinal tract has received little attention. 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| ispartof | Gastroenterology (New York, N.Y. 1943), 1989-09, Vol.97 (3), p.575-585 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Alma/SFX Local Collection |
| subjects | Adult Aged Axons - ultrastructure Biological and medical sciences Cell interactions, adhesion Female Fundamental and applied biological sciences. Psychology Humans Immunoenzyme Techniques Intestinal Mucosa - anatomy & histology Male Mast Cells - ultrastructure Microscopy, Electron Middle Aged Molecular and cellular biology Nerve Fibers - ultrastructure Nerve Net - ultrastructure |
| title | Mast cells are closely apposed to nerves in the human gastrointestinal mucosa |
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