Synthesis and Cellular Uptake of 2‘-Substituted Analogues of (E)-5-(2-[125I]Iodovinyl)-2‘-deoxyuridine in Tumor Cells Transduced with the Herpes Simplex Type-1 Thymidine Kinase Gene. Evaluation as Probes for Monitoring Gene Therapy

A useful synthetic methodology was developed to synthesize and radiolabel a series of (E)-5-(2-[125I]iodovinyl)uracil nucleoside substrates for herpes simplex virus type-1 thymidine kinase (HSV-1 TK). (E)-5-(2-[125I]Iodovinyl)-2‘-deoxyuridine ([125I]IVDU, 10), (E)-5-(2-[125I]iodovinyl)-2‘-fluoro-2‘-...

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Veröffentlicht in:	Journal of medicinal chemistry 1997-07, Vol.40 (14), p.2184-2190
Hauptverfasser:	Morin, Kevin W, Atrazheva, Elena D, Knaus, Edward E, Wiebe, Leonard I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antiviral Agents - chemical synthesis Antiviral Agents - pharmacokinetics Antiviral Agents - pharmacology Biological and medical sciences Biological Transport Cell Line General aspects Genes, Viral Genetic Therapy - methods Genetic Vectors Herpesvirus 1, Human - enzymology Herpesvirus 1, Human - genetics Idoxuridine - analogs & derivatives Idoxuridine - chemical synthesis Idoxuridine - pharmacokinetics Idoxuridine - pharmacology Indicators and Reagents Iodine Radioisotopes Isotope Labeling - methods Kinetics Medical sciences Mice Molecular Structure Moloney murine leukemia virus Monitoring, Physiologic - methods Pharmacology. Drug treatments Recombinant Proteins - biosynthesis Structure-Activity Relationship Thymidine Kinase - biosynthesis Thymidine Kinase - genetics Transfection
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