Platelet adherence and thrombus formation with flowing human blood on atherosclerotic plaque: Reduced thrombogenicity of watanabe-heritable hyperlipidemic rabbit aortic subendothelium
Platelet adherence and aggregation are important in the development of ischemic sequelae in atherosclerosis. To directly examine platelet interaction with plaque, everted, deendothelialized aortic fibrous plaques from Watanabe-heritable hyperlipidemic rabbits were exposed to flowing human blood in a...
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| Veröffentlicht in: | Thrombosis research 1989-04, Vol.54 (2), p.99-114 |
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| creator | Lawrence, Jeffry B. Prevosti, Louis G. Kramer, Wendy S. Lu, David Y. Leon, Martin B. |
| description | Platelet adherence and aggregation are important in the development of ischemic sequelae in atherosclerosis. To directly examine platelet interaction with plaque, everted, deendothelialized aortic fibrous plaques from Watanabe-heritable hyperlipidemic rabbits were exposed to flowing human blood in an annular perfusion chamber. Morphometry was used to compare platelet adherence and thrombi on this surface with that observed when blood was perfused over normal New Zealand White (NZW) rabbit aortic subendothelium. Platelet spreading, adherence, and thrombi on the atherosclerotic surface were approximately half that observed on NZW aorta. When surface proteins of NZW aorta were denatured by a hot-tip catheter, these parameters were reduced by 89–96%. The reduced thrombogenicity of uncomplicated plaques may help keep these narrowed vessels patient, while fissure, rupture, or hemorrhagic dissection of plaque may precipitate occlusive thrombosis. |
| doi_str_mv | 10.1016/0049-3848(89)90040-6 |
| format | Article |
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To directly examine platelet interaction with plaque, everted, deendothelialized aortic fibrous plaques from Watanabe-heritable hyperlipidemic rabbits were exposed to flowing human blood in an annular perfusion chamber. Morphometry was used to compare platelet adherence and thrombi on this surface with that observed when blood was perfused over normal New Zealand White (NZW) rabbit aortic subendothelium. Platelet spreading, adherence, and thrombi on the atherosclerotic surface were approximately half that observed on NZW aorta. When surface proteins of NZW aorta were denatured by a hot-tip catheter, these parameters were reduced by 89–96%. The reduced thrombogenicity of uncomplicated plaques may help keep these narrowed vessels patient, while fissure, rupture, or hemorrhagic dissection of plaque may precipitate occlusive thrombosis.</description><identifier>ISSN: 0049-3848</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/0049-3848(89)90040-6</identifier><identifier>PMID: 2749610</identifier><identifier>CODEN: THBRAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Ltd</publisher><subject>Animals ; Aorta - analysis ; Aorta - ultrastructure ; Arteriosclerosis - complications ; Arteriosclerosis - physiopathology ; atherosclerosis ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Platelets - physiology ; Blood Platelets - ultrastructure ; Cardiology. Vascular system ; Endothelium, Vascular ; Medical sciences ; Microscopy, Electron ; Perfusion - methods ; platelet adherence ; Platelet Adhesiveness ; platelet spreading ; Platelets ; Rabbits ; Regional Blood Flow ; surface thrombogenicity ; thrombosis ; Thrombosis - etiology ; Thrombosis - physiopathology</subject><ispartof>Thrombosis research, 1989-04, Vol.54 (2), p.99-114</ispartof><rights>1989</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-f6de1c0af748c18f4f4dae8375f7445d1614e70da5981f5613e1e88a05bd03c3</citedby><cites>FETCH-LOGICAL-c386t-f6de1c0af748c18f4f4dae8375f7445d1614e70da5981f5613e1e88a05bd03c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0049384889900406$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7187751$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2749610$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lawrence, Jeffry B.</creatorcontrib><creatorcontrib>Prevosti, Louis G.</creatorcontrib><creatorcontrib>Kramer, Wendy S.</creatorcontrib><creatorcontrib>Lu, David Y.</creatorcontrib><creatorcontrib>Leon, Martin B.</creatorcontrib><title>Platelet adherence and thrombus formation with flowing human blood on atherosclerotic plaque: Reduced thrombogenicity of watanabe-heritable hyperlipidemic rabbit aortic subendothelium</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Platelet adherence and aggregation are important in the development of ischemic sequelae in atherosclerosis. To directly examine platelet interaction with plaque, everted, deendothelialized aortic fibrous plaques from Watanabe-heritable hyperlipidemic rabbits were exposed to flowing human blood in an annular perfusion chamber. Morphometry was used to compare platelet adherence and thrombi on this surface with that observed when blood was perfused over normal New Zealand White (NZW) rabbit aortic subendothelium. Platelet spreading, adherence, and thrombi on the atherosclerotic surface were approximately half that observed on NZW aorta. When surface proteins of NZW aorta were denatured by a hot-tip catheter, these parameters were reduced by 89–96%. The reduced thrombogenicity of uncomplicated plaques may help keep these narrowed vessels patient, while fissure, rupture, or hemorrhagic dissection of plaque may precipitate occlusive thrombosis.</description><subject>Animals</subject><subject>Aorta - analysis</subject><subject>Aorta - ultrastructure</subject><subject>Arteriosclerosis - complications</subject><subject>Arteriosclerosis - physiopathology</subject><subject>atherosclerosis</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Platelets - physiology</subject><subject>Blood Platelets - ultrastructure</subject><subject>Cardiology. Vascular system</subject><subject>Endothelium, Vascular</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Perfusion - methods</subject><subject>platelet adherence</subject><subject>Platelet Adhesiveness</subject><subject>platelet spreading</subject><subject>Platelets</subject><subject>Rabbits</subject><subject>Regional Blood Flow</subject><subject>surface thrombogenicity</subject><subject>thrombosis</subject><subject>Thrombosis - etiology</subject><subject>Thrombosis - physiopathology</subject><issn>0049-3848</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-O1SAUxhujGe-MvoEmLIzRRRVa2lIXJmYy_kkm0ZjZk1M4TDG0VKDe3Cfz9aTe6126gcD5vo_D-RXFM0bfMMrat5TyvqwFF69E_7rPJ1q2D4odE11fVryrHha7s-RxcRnjD0pZx_rmorioOt63jO6K398cJHSYCOgRA84KCcyapDH4aVgjMT5MkKyfyd6mkRjn93a-J-M6wUwG570muQYpm31ULq_JKrI4-LniO_Id9arwX5y_x9kqmw7EG7KHBDMMWGanTTA4JONhweDsYjVOOSTAMNjcmA9bZFwHnLXPDzm7Tk-KRwZcxKen_aq4-3hzd_25vP366cv1h9tS1aJNpWk1MkXBdFwoJgw3XAOKumvyDW80axnHjmpoesFM07IaGQoBtBk0rVV9Vbw8xi7B5w_FJCcbFToHM_o1yq5ntGmrKgv5UajyGGJAI5dgJwgHyajccMmNhdxYSNHLv7hkm23PT_nrMKE-m058cv3FqQ5RgTMBZmXjWdZl2F3Dsuz9UYZ5FL8sBhmV3VhqG1Alqb39fx9_AEtntzE</recordid><startdate>19890415</startdate><enddate>19890415</enddate><creator>Lawrence, Jeffry B.</creator><creator>Prevosti, Louis G.</creator><creator>Kramer, Wendy S.</creator><creator>Lu, David Y.</creator><creator>Leon, Martin B.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19890415</creationdate><title>Platelet adherence and thrombus formation with flowing human blood on atherosclerotic plaque: Reduced thrombogenicity of watanabe-heritable hyperlipidemic rabbit aortic subendothelium</title><author>Lawrence, Jeffry B. ; Prevosti, Louis G. ; Kramer, Wendy S. ; Lu, David Y. ; Leon, Martin B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f6de1c0af748c18f4f4dae8375f7445d1614e70da5981f5613e1e88a05bd03c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Aorta - analysis</topic><topic>Aorta - ultrastructure</topic><topic>Arteriosclerosis - complications</topic><topic>Arteriosclerosis - physiopathology</topic><topic>atherosclerosis</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Platelets - physiology</topic><topic>Blood Platelets - ultrastructure</topic><topic>Cardiology. Vascular system</topic><topic>Endothelium, Vascular</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Perfusion - methods</topic><topic>platelet adherence</topic><topic>Platelet Adhesiveness</topic><topic>platelet spreading</topic><topic>Platelets</topic><topic>Rabbits</topic><topic>Regional Blood Flow</topic><topic>surface thrombogenicity</topic><topic>thrombosis</topic><topic>Thrombosis - etiology</topic><topic>Thrombosis - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lawrence, Jeffry B.</creatorcontrib><creatorcontrib>Prevosti, Louis G.</creatorcontrib><creatorcontrib>Kramer, Wendy S.</creatorcontrib><creatorcontrib>Lu, David Y.</creatorcontrib><creatorcontrib>Leon, Martin B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lawrence, Jeffry B.</au><au>Prevosti, Louis G.</au><au>Kramer, Wendy S.</au><au>Lu, David Y.</au><au>Leon, Martin B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet adherence and thrombus formation with flowing human blood on atherosclerotic plaque: Reduced thrombogenicity of watanabe-heritable hyperlipidemic rabbit aortic subendothelium</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>1989-04-15</date><risdate>1989</risdate><volume>54</volume><issue>2</issue><spage>99</spage><epage>114</epage><pages>99-114</pages><issn>0049-3848</issn><eissn>1879-2472</eissn><coden>THBRAA</coden><abstract>Platelet adherence and aggregation are important in the development of ischemic sequelae in atherosclerosis. To directly examine platelet interaction with plaque, everted, deendothelialized aortic fibrous plaques from Watanabe-heritable hyperlipidemic rabbits were exposed to flowing human blood in an annular perfusion chamber. Morphometry was used to compare platelet adherence and thrombi on this surface with that observed when blood was perfused over normal New Zealand White (NZW) rabbit aortic subendothelium. Platelet spreading, adherence, and thrombi on the atherosclerotic surface were approximately half that observed on NZW aorta. When surface proteins of NZW aorta were denatured by a hot-tip catheter, these parameters were reduced by 89–96%. The reduced thrombogenicity of uncomplicated plaques may help keep these narrowed vessels patient, while fissure, rupture, or hemorrhagic dissection of plaque may precipitate occlusive thrombosis.</abstract><cop>New York, NY</cop><pub>Elsevier Ltd</pub><pmid>2749610</pmid><doi>10.1016/0049-3848(89)90040-6</doi><tpages>16</tpages></addata></record> |
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| subjects | Animals Aorta - analysis Aorta - ultrastructure Arteriosclerosis - complications Arteriosclerosis - physiopathology atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Platelets - physiology Blood Platelets - ultrastructure Cardiology. Vascular system Endothelium, Vascular Medical sciences Microscopy, Electron Perfusion - methods platelet adherence Platelet Adhesiveness platelet spreading Platelets Rabbits Regional Blood Flow surface thrombogenicity thrombosis Thrombosis - etiology Thrombosis - physiopathology |
| title | Platelet adherence and thrombus formation with flowing human blood on atherosclerotic plaque: Reduced thrombogenicity of watanabe-heritable hyperlipidemic rabbit aortic subendothelium |
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