Functional assay of multidrug resistant cells using JC-1, a carbocyanine fluorescent probe

Multidrug resistance (MDR) is characterized by a decrease in the efficiency of chemotherapeutic agents correlated with the expression and activity of a membrane protein: the permeability-glycoprotein (Pgp 170). Clinically, detection of MDR can be performed by functional tests based on the accumulati...

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Veröffentlicht in:	Leukemia 1997-07, Vol.11 (7), p.1147-1155
Hauptverfasser:	Kühnel, J M, Perrot, J Y, Faussat, A M, Marie, J P, Schwaller, M A
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Aggregates Antibodies ATP-Binding Cassette, Sub-Family B, Member 1 - analysis Benzimidazoles - metabolism Carbocyanines - metabolism Chemical compounds Chemotherapy Cyclosporins Drug resistance Drug Resistance, Multiple Emission spectra Flow Cytometry Fluorescence Fluorescent Dyes - metabolism Fluorescent indicators Functional testing Glycoproteins Humans Lipophilic Liquid crystals Membrane permeability Membrane proteins Mitochondria Monomers Multidrug resistance Multidrug resistant organisms Rhodamine Rhodamine 123 Rhodamines - metabolism Sensitivity analysis Spectrometry, Fluorescence Tumor Cells, Cultured Verapamil
Online-Zugang:	Volltext
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