Comparison of Fractionated to Single-Dose Total Body Irradiation in Conditioning Canine Littermates for DLA-Identical Marrow Grafts

We explored the ability of fractionated total body irradiation (TBI) given at a rate of 7 cGy/min from opposing dual ∞Co sources at otherwise lethal doses of 450, 600, 700, 800, and 920 cGy to condition dogs for marrow grafts from DLA-identical littermates. Results were compared with those of a prev...

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Veröffentlicht in:	Blood 1989-08, Vol.74 (3), p.1139-1143
Hauptverfasser:	Storb, Rainer, Raff, Robert F., Appelbaum, Frederick R., Graham, Theodore C., Schuening, Friedrich G., Sale, George, Pepe, Margaret
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Blood Cell Count - radiation effects Bone Marrow - radiation effects Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Dogs Dose-Response Relationship, Radiation Graft Rejection - radiation effects Histocompatibility Antigens - genetics Histocompatibility Antigens Class I Immunosuppression - methods Medical sciences Preoperative Care - methods Radiation Chimera Transfusions. Complications. Transfusion reactions. Cell and gene therapy Whole-Body Irradiation - methods
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