Evaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significance
Purpose The purpose was to study the prognostic value of contrast‐enhanced computed tomography (CT) nodal necrosis in nasopharyngeal carcinoma. Patients and Methods One hundred sixty‐one patients with newly diagnosed nasopharyngeal carcinoma and nodal metastases were reviewed. Forty patients also re...
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| Veröffentlicht in: | Head & neck 1997-07, Vol.19 (4), p.266-275 |
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| creator | Chua, Daniel T. T. Sham, Jonathan S. T. Kwong, Dora L. W. Choy, Damon T. K. Leong, Lilian Chan, F. L. |
| description | Purpose
The purpose was to study the prognostic value of contrast‐enhanced computed tomography (CT) nodal necrosis in nasopharyngeal carcinoma.
Patients and Methods
One hundred sixty‐one patients with newly diagnosed nasopharyngeal carcinoma and nodal metastases were reviewed. Forty patients also received cisplatin‐based neoadjuvant chemotherapy in addition to radiotherapy. Nodal necrosis was defined as presence of hypodense areas in more than 33% of the node. Nodal response rate to chemotherapy, overall nodal control rate, local control rate, distant failure rate, overall relapse‐free survival rate, and overall and cause‐specific survival rates were compared between patients with and without nodal necrosis. Multivariate analysis was also performed.
Results
The incidence of nodal necrosis was 22.9%. Overall nodal response rates to chemotherapy were 88.9% (8/9) in patients with nodal necrosis and 74.2% (23/31) in those without. No significant differences in nodal control rate, local control rate, distant failure rate, and overall and cause‐specific survival rates were found. Five‐year overall relapse‐free survival rate was lower in patients with cervical nodal necrosis (36%) as compared with those without (53%, p = .04). Multivariate analysis, however, did not confirm cervical nodal necrosis to be an independent prognostic factor.
Conclusions
Presence of nodal necrosis in nasopharyngeal carcinoma does not affect nodal response to chemotherapy and nodal control by radiotherapy with or without chemotherapy. Cervical nodal necrosis does not appear to be an independent factor in predicting treatment outcome. Further studies to correlate nodal density with oxygenation status as well as tumor cell kinetics are warranted. © 1997 John Wiley & Sons, Inc. Head Neck 19: 266–275, 1997. |
| doi_str_mv | 10.1002/(SICI)1097-0347(199707)19:4<266::AID-HED4>3.0.CO;2-Z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79103902</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79103902</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3594-e64c1748b99572ed706483c4bddb2aa2ef64f60e85c47116cf8da723d40cf33d3</originalsourceid><addsrcrecordid>eNqFUV1v0zAUjRBojMFPQPIDQttDir8aN2VCmrrSBU1UYkOgvVw5ttMZEjvE6bY-8ddxaFUeQOLF19a5Pvfcc5LklOARwZi-Ob4qZsUJwblIMePimOS5wOKE5FN-SrNsOj0rztOL-Tl_x0Z4NFu-penNo-Rw_-HxcOcsZVjwp8mzEL5hjFnG6UFykFPCIniY_JzfyXote-sd8hVSpruzStbIeT2cRnU-2ICsQ04G397KbuNWJkJKdso630hUbpDyTbvujUa9b_yqk-3tZooKp6w2ThkknUZt51fOh94qFOzK2SqOidjz5Ekl62Be7OpR8vn9_Hp2kV4uF8Xs7DJVbJzz1GRcEcEnZZ6PBTVa4IxPmOKl1iWVkpoq41WGzWSsuCAkU9VES0GZ5lhVjGl2lLze8kYdP9Ym9NDYoExdS2f8OoDICWY5prHxets4bB46U0Hb2SauDQTDkAvAkAsMNsNgM2xziQU4xFwAYi4w5AIMMMyWQOEm0r7czV-XjdF70l0QEX-1w2WI_lddNMeGfRsVNEaX_VF3b2uz-Uvaf5T9Q9jvd6RNt7Q29OZhTyu775AJJsbw5eMCFuTrFaXsA3xivwCLUMY1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79103902</pqid></control><display><type>article</type><title>Evaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significance</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Chua, Daniel T. T. ; Sham, Jonathan S. T. ; Kwong, Dora L. W. ; Choy, Damon T. K. ; Leong, Lilian ; Chan, F. L.</creator><creatorcontrib>Chua, Daniel T. T. ; Sham, Jonathan S. T. ; Kwong, Dora L. W. ; Choy, Damon T. K. ; Leong, Lilian ; Chan, F. L.</creatorcontrib><description>Purpose
The purpose was to study the prognostic value of contrast‐enhanced computed tomography (CT) nodal necrosis in nasopharyngeal carcinoma.
Patients and Methods
One hundred sixty‐one patients with newly diagnosed nasopharyngeal carcinoma and nodal metastases were reviewed. Forty patients also received cisplatin‐based neoadjuvant chemotherapy in addition to radiotherapy. Nodal necrosis was defined as presence of hypodense areas in more than 33% of the node. Nodal response rate to chemotherapy, overall nodal control rate, local control rate, distant failure rate, overall relapse‐free survival rate, and overall and cause‐specific survival rates were compared between patients with and without nodal necrosis. Multivariate analysis was also performed.
Results
The incidence of nodal necrosis was 22.9%. Overall nodal response rates to chemotherapy were 88.9% (8/9) in patients with nodal necrosis and 74.2% (23/31) in those without. No significant differences in nodal control rate, local control rate, distant failure rate, and overall and cause‐specific survival rates were found. Five‐year overall relapse‐free survival rate was lower in patients with cervical nodal necrosis (36%) as compared with those without (53%, p = .04). Multivariate analysis, however, did not confirm cervical nodal necrosis to be an independent prognostic factor.
Conclusions
Presence of nodal necrosis in nasopharyngeal carcinoma does not affect nodal response to chemotherapy and nodal control by radiotherapy with or without chemotherapy. Cervical nodal necrosis does not appear to be an independent factor in predicting treatment outcome. Further studies to correlate nodal density with oxygenation status as well as tumor cell kinetics are warranted. © 1997 John Wiley & Sons, Inc. Head Neck 19: 266–275, 1997.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/(SICI)1097-0347(199707)19:4<266::AID-HED4>3.0.CO;2-Z</identifier><identifier>PMID: 9213104</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Analysis of Variance ; Biological and medical sciences ; chemotherapy ; Chemotherapy, Adjuvant ; Combined Modality Therapy ; computed tomography ; Female ; Humans ; Lymphatic Metastasis - pathology ; Male ; Medical sciences ; Middle Aged ; nasopharyngeal carcinoma ; Nasopharyngeal Neoplasms - diagnostic imaging ; Nasopharyngeal Neoplasms - drug therapy ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - radiotherapy ; Necrosis ; Neoplasm Staging ; nodal necrosis ; Otorhinolaryngology. Stomatology ; Prognosis ; radiotherapy ; Survival Rate ; Tomography, X-Ray Computed ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Head & neck, 1997-07, Vol.19 (4), p.266-275</ispartof><rights>Copyright © 1997 John Wiley & Sons, Inc.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3594-e64c1748b99572ed706483c4bddb2aa2ef64f60e85c47116cf8da723d40cf33d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F%28SICI%291097-0347%28199707%2919%3A4%3C266%3A%3AAID-HED4%3E3.0.CO%3B2-Z$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F%28SICI%291097-0347%28199707%2919%3A4%3C266%3A%3AAID-HED4%3E3.0.CO%3B2-Z$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2720366$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9213104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chua, Daniel T. T.</creatorcontrib><creatorcontrib>Sham, Jonathan S. T.</creatorcontrib><creatorcontrib>Kwong, Dora L. W.</creatorcontrib><creatorcontrib>Choy, Damon T. K.</creatorcontrib><creatorcontrib>Leong, Lilian</creatorcontrib><creatorcontrib>Chan, F. L.</creatorcontrib><title>Evaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significance</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Purpose
The purpose was to study the prognostic value of contrast‐enhanced computed tomography (CT) nodal necrosis in nasopharyngeal carcinoma.
Patients and Methods
One hundred sixty‐one patients with newly diagnosed nasopharyngeal carcinoma and nodal metastases were reviewed. Forty patients also received cisplatin‐based neoadjuvant chemotherapy in addition to radiotherapy. Nodal necrosis was defined as presence of hypodense areas in more than 33% of the node. Nodal response rate to chemotherapy, overall nodal control rate, local control rate, distant failure rate, overall relapse‐free survival rate, and overall and cause‐specific survival rates were compared between patients with and without nodal necrosis. Multivariate analysis was also performed.
Results
The incidence of nodal necrosis was 22.9%. Overall nodal response rates to chemotherapy were 88.9% (8/9) in patients with nodal necrosis and 74.2% (23/31) in those without. No significant differences in nodal control rate, local control rate, distant failure rate, and overall and cause‐specific survival rates were found. Five‐year overall relapse‐free survival rate was lower in patients with cervical nodal necrosis (36%) as compared with those without (53%, p = .04). Multivariate analysis, however, did not confirm cervical nodal necrosis to be an independent prognostic factor.
Conclusions
Presence of nodal necrosis in nasopharyngeal carcinoma does not affect nodal response to chemotherapy and nodal control by radiotherapy with or without chemotherapy. Cervical nodal necrosis does not appear to be an independent factor in predicting treatment outcome. Further studies to correlate nodal density with oxygenation status as well as tumor cell kinetics are warranted. © 1997 John Wiley & Sons, Inc. Head Neck 19: 266–275, 1997.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>chemotherapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Combined Modality Therapy</subject><subject>computed tomography</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>nasopharyngeal carcinoma</subject><subject>Nasopharyngeal Neoplasms - diagnostic imaging</subject><subject>Nasopharyngeal Neoplasms - drug therapy</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - radiotherapy</subject><subject>Necrosis</subject><subject>Neoplasm Staging</subject><subject>nodal necrosis</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>radiotherapy</subject><subject>Survival Rate</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUV1v0zAUjRBojMFPQPIDQttDir8aN2VCmrrSBU1UYkOgvVw5ttMZEjvE6bY-8ddxaFUeQOLF19a5Pvfcc5LklOARwZi-Ob4qZsUJwblIMePimOS5wOKE5FN-SrNsOj0rztOL-Tl_x0Z4NFu-penNo-Rw_-HxcOcsZVjwp8mzEL5hjFnG6UFykFPCIniY_JzfyXote-sd8hVSpruzStbIeT2cRnU-2ICsQ04G397KbuNWJkJKdso630hUbpDyTbvujUa9b_yqk-3tZooKp6w2ThkknUZt51fOh94qFOzK2SqOidjz5Ekl62Be7OpR8vn9_Hp2kV4uF8Xs7DJVbJzz1GRcEcEnZZ6PBTVa4IxPmOKl1iWVkpoq41WGzWSsuCAkU9VES0GZ5lhVjGl2lLze8kYdP9Ym9NDYoExdS2f8OoDICWY5prHxets4bB46U0Hb2SauDQTDkAvAkAsMNsNgM2xziQU4xFwAYi4w5AIMMMyWQOEm0r7czV-XjdF70l0QEX-1w2WI_lddNMeGfRsVNEaX_VF3b2uz-Uvaf5T9Q9jvd6RNt7Q29OZhTyu775AJJsbw5eMCFuTrFaXsA3xivwCLUMY1</recordid><startdate>199707</startdate><enddate>199707</enddate><creator>Chua, Daniel T. T.</creator><creator>Sham, Jonathan S. T.</creator><creator>Kwong, Dora L. W.</creator><creator>Choy, Damon T. K.</creator><creator>Leong, Lilian</creator><creator>Chan, F. L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199707</creationdate><title>Evaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significance</title><author>Chua, Daniel T. T. ; Sham, Jonathan S. T. ; Kwong, Dora L. W. ; Choy, Damon T. K. ; Leong, Lilian ; Chan, F. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3594-e64c1748b99572ed706483c4bddb2aa2ef64f60e85c47116cf8da723d40cf33d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>chemotherapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Combined Modality Therapy</topic><topic>computed tomography</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>nasopharyngeal carcinoma</topic><topic>Nasopharyngeal Neoplasms - diagnostic imaging</topic><topic>Nasopharyngeal Neoplasms - drug therapy</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharyngeal Neoplasms - radiotherapy</topic><topic>Necrosis</topic><topic>Neoplasm Staging</topic><topic>nodal necrosis</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>radiotherapy</topic><topic>Survival Rate</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chua, Daniel T. T.</creatorcontrib><creatorcontrib>Sham, Jonathan S. T.</creatorcontrib><creatorcontrib>Kwong, Dora L. W.</creatorcontrib><creatorcontrib>Choy, Damon T. K.</creatorcontrib><creatorcontrib>Leong, Lilian</creatorcontrib><creatorcontrib>Chan, F. L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chua, Daniel T. T.</au><au>Sham, Jonathan S. T.</au><au>Kwong, Dora L. W.</au><au>Choy, Damon T. K.</au><au>Leong, Lilian</au><au>Chan, F. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significance</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>1997-07</date><risdate>1997</risdate><volume>19</volume><issue>4</issue><spage>266</spage><epage>275</epage><pages>266-275</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Purpose
The purpose was to study the prognostic value of contrast‐enhanced computed tomography (CT) nodal necrosis in nasopharyngeal carcinoma.
Patients and Methods
One hundred sixty‐one patients with newly diagnosed nasopharyngeal carcinoma and nodal metastases were reviewed. Forty patients also received cisplatin‐based neoadjuvant chemotherapy in addition to radiotherapy. Nodal necrosis was defined as presence of hypodense areas in more than 33% of the node. Nodal response rate to chemotherapy, overall nodal control rate, local control rate, distant failure rate, overall relapse‐free survival rate, and overall and cause‐specific survival rates were compared between patients with and without nodal necrosis. Multivariate analysis was also performed.
Results
The incidence of nodal necrosis was 22.9%. Overall nodal response rates to chemotherapy were 88.9% (8/9) in patients with nodal necrosis and 74.2% (23/31) in those without. No significant differences in nodal control rate, local control rate, distant failure rate, and overall and cause‐specific survival rates were found. Five‐year overall relapse‐free survival rate was lower in patients with cervical nodal necrosis (36%) as compared with those without (53%, p = .04). Multivariate analysis, however, did not confirm cervical nodal necrosis to be an independent prognostic factor.
Conclusions
Presence of nodal necrosis in nasopharyngeal carcinoma does not affect nodal response to chemotherapy and nodal control by radiotherapy with or without chemotherapy. Cervical nodal necrosis does not appear to be an independent factor in predicting treatment outcome. Further studies to correlate nodal density with oxygenation status as well as tumor cell kinetics are warranted. © 1997 John Wiley & Sons, Inc. Head Neck 19: 266–275, 1997.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>9213104</pmid><doi>10.1002/(SICI)1097-0347(199707)19:4<266::AID-HED4>3.0.CO;2-Z</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Analysis of Variance Biological and medical sciences chemotherapy Chemotherapy, Adjuvant Combined Modality Therapy computed tomography Female Humans Lymphatic Metastasis - pathology Male Medical sciences Middle Aged nasopharyngeal carcinoma Nasopharyngeal Neoplasms - diagnostic imaging Nasopharyngeal Neoplasms - drug therapy Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - radiotherapy Necrosis Neoplasm Staging nodal necrosis Otorhinolaryngology. Stomatology Prognosis radiotherapy Survival Rate Tomography, X-Ray Computed Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Evaluation of cervical nodal necrosis in nasopharyngeal carcinoma by computed tomography: Incidence and prognostic significance |
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