Assessment of Antihypertensive Effect by Blood Pressure Monitoring: Applications to Bisoprolol and Lisinopril in a Double-Blind Study
The aim of this study was to evaluate the antihypertensive effect of drugs according to the initial ambulatory blood pressure (BP) level. After a 15-day placebo run-in period, 105 patients with moderate essential hypertension (mean age, 52 years) underwent 24-h BP monitoring (spacelabs1 measure/15 m...
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| Veröffentlicht in: | Journal of cardiovascular pharmacology 1997-05, Vol.29 (5), p.612-617 |
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| container_title | Journal of cardiovascular pharmacology |
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| creator | Vaïsse, B Herpin, D Asmar, R Battistella, P Zannad, F Boutelant, S Lyon, A Conte, D Denis, J Honore, Ph Contard, S Prost, P-L Mallion, J M Poggi, L |
| description | The aim of this study was to evaluate the antihypertensive effect of drugs according to the initial ambulatory blood pressure (BP) level. After a 15-day placebo run-in period, 105 patients with moderate essential hypertension (mean age, 52 years) underwent 24-h BP monitoring (spacelabs1 measure/15 min). Patients were subdivided into two groupsthe "High" group, with 24-h mean values of systolic BP (SBP) >137 or diastolic BP (DBP) >87 mm Hg, and the "Low" group, with SBP ≤ 137 and DBP ≤ 87 mm Hg. All patients received, in a random and double-blind design, either bisoprolol (10 mg q.d.) or lisinopril (20 mg q.d.) for 8 weeks. At the end of this active treatment period office and ambulatory BP measurements were performed. Casual measurements revealed similar BP decreases in all subgroups receiving bisoprolol and lisinopril; BP monitoring showed that the antihypertensive effect depended on the baseline mean 24-h value; −15/−12 mm Hg for bisoprolol and −18/−13 mm Hg for lisinopril in the High group; −7/−6 mm Hg for bisoprolol and −6/−6 mm Hg for lisinopril in the Low group. This study shows that the antihypertensive effect depended on initial ambulatory BP values, with a lower BP decrease in the Low group. Assessment of the antihypertensive effect on ambulatory BP is useful in clinical trials. |
| doi_str_mv | 10.1097/00005344-199705000-00008 |
| format | Article |
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After a 15-day placebo run-in period, 105 patients with moderate essential hypertension (mean age, 52 years) underwent 24-h BP monitoring (spacelabs1 measure/15 min). Patients were subdivided into two groupsthe "High" group, with 24-h mean values of systolic BP (SBP) >137 or diastolic BP (DBP) >87 mm Hg, and the "Low" group, with SBP ≤ 137 and DBP ≤ 87 mm Hg. All patients received, in a random and double-blind design, either bisoprolol (10 mg q.d.) or lisinopril (20 mg q.d.) for 8 weeks. At the end of this active treatment period office and ambulatory BP measurements were performed. Casual measurements revealed similar BP decreases in all subgroups receiving bisoprolol and lisinopril; BP monitoring showed that the antihypertensive effect depended on the baseline mean 24-h value; −15/−12 mm Hg for bisoprolol and −18/−13 mm Hg for lisinopril in the High group; −7/−6 mm Hg for bisoprolol and −6/−6 mm Hg for lisinopril in the Low group. This study shows that the antihypertensive effect depended on initial ambulatory BP values, with a lower BP decrease in the Low group. Assessment of the antihypertensive effect on ambulatory BP is useful in clinical trials.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-199705000-00008</identifier><identifier>PMID: 9213203</identifier><identifier>CODEN: JCPCDT</identifier><language>eng</language><publisher>Philadelphia, PA: Lippincott-Raven Publishers</publisher><subject>Adrenergic beta-Antagonists - therapeutic use ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Antihypertensive agents ; Antihypertensive Agents - therapeutic use ; Biological and medical sciences ; Bisoprolol - therapeutic use ; Blood Pressure Monitoring, Ambulatory ; Cardiovascular system ; Double-Blind Method ; Female ; Humans ; Hypertension - drug therapy ; Hypertension - physiopathology ; Lisinopril - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Pharmacology. 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After a 15-day placebo run-in period, 105 patients with moderate essential hypertension (mean age, 52 years) underwent 24-h BP monitoring (spacelabs1 measure/15 min). Patients were subdivided into two groupsthe "High" group, with 24-h mean values of systolic BP (SBP) >137 or diastolic BP (DBP) >87 mm Hg, and the "Low" group, with SBP ≤ 137 and DBP ≤ 87 mm Hg. All patients received, in a random and double-blind design, either bisoprolol (10 mg q.d.) or lisinopril (20 mg q.d.) for 8 weeks. At the end of this active treatment period office and ambulatory BP measurements were performed. Casual measurements revealed similar BP decreases in all subgroups receiving bisoprolol and lisinopril; BP monitoring showed that the antihypertensive effect depended on the baseline mean 24-h value; −15/−12 mm Hg for bisoprolol and −18/−13 mm Hg for lisinopril in the High group; −7/−6 mm Hg for bisoprolol and −6/−6 mm Hg for lisinopril in the Low group. This study shows that the antihypertensive effect depended on initial ambulatory BP values, with a lower BP decrease in the Low group. Assessment of the antihypertensive effect on ambulatory BP is useful in clinical trials.</description><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Antihypertensive agents</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Bisoprolol - therapeutic use</subject><subject>Blood Pressure Monitoring, Ambulatory</subject><subject>Cardiovascular system</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Lisinopril - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. 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Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vaïsse, B</creatorcontrib><creatorcontrib>Herpin, D</creatorcontrib><creatorcontrib>Asmar, R</creatorcontrib><creatorcontrib>Battistella, P</creatorcontrib><creatorcontrib>Zannad, F</creatorcontrib><creatorcontrib>Boutelant, S</creatorcontrib><creatorcontrib>Lyon, A</creatorcontrib><creatorcontrib>Conte, D</creatorcontrib><creatorcontrib>Denis, J</creatorcontrib><creatorcontrib>Honore, Ph</creatorcontrib><creatorcontrib>Contard, S</creatorcontrib><creatorcontrib>Prost, P-L</creatorcontrib><creatorcontrib>Mallion, J M</creatorcontrib><creatorcontrib>Poggi, L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vaïsse, B</au><au>Herpin, D</au><au>Asmar, R</au><au>Battistella, P</au><au>Zannad, F</au><au>Boutelant, S</au><au>Lyon, A</au><au>Conte, D</au><au>Denis, J</au><au>Honore, Ph</au><au>Contard, S</au><au>Prost, P-L</au><au>Mallion, J M</au><au>Poggi, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of Antihypertensive Effect by Blood Pressure Monitoring: Applications to Bisoprolol and Lisinopril in a Double-Blind Study</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1997-05</date><risdate>1997</risdate><volume>29</volume><issue>5</issue><spage>612</spage><epage>617</epage><pages>612-617</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><coden>JCPCDT</coden><abstract>The aim of this study was to evaluate the antihypertensive effect of drugs according to the initial ambulatory blood pressure (BP) level. After a 15-day placebo run-in period, 105 patients with moderate essential hypertension (mean age, 52 years) underwent 24-h BP monitoring (spacelabs1 measure/15 min). Patients were subdivided into two groupsthe "High" group, with 24-h mean values of systolic BP (SBP) >137 or diastolic BP (DBP) >87 mm Hg, and the "Low" group, with SBP ≤ 137 and DBP ≤ 87 mm Hg. All patients received, in a random and double-blind design, either bisoprolol (10 mg q.d.) or lisinopril (20 mg q.d.) for 8 weeks. At the end of this active treatment period office and ambulatory BP measurements were performed. Casual measurements revealed similar BP decreases in all subgroups receiving bisoprolol and lisinopril; BP monitoring showed that the antihypertensive effect depended on the baseline mean 24-h value; −15/−12 mm Hg for bisoprolol and −18/−13 mm Hg for lisinopril in the High group; −7/−6 mm Hg for bisoprolol and −6/−6 mm Hg for lisinopril in the Low group. This study shows that the antihypertensive effect depended on initial ambulatory BP values, with a lower BP decrease in the Low group. Assessment of the antihypertensive effect on ambulatory BP is useful in clinical trials.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>9213203</pmid><doi>10.1097/00005344-199705000-00008</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of cardiovascular pharmacology, 1997-05, Vol.29 (5), p.612-617 |
| issn | 0160-2446 1533-4023 |
| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Adrenergic beta-Antagonists - therapeutic use Angiotensin-Converting Enzyme Inhibitors - therapeutic use Antihypertensive agents Antihypertensive Agents - therapeutic use Biological and medical sciences Bisoprolol - therapeutic use Blood Pressure Monitoring, Ambulatory Cardiovascular system Double-Blind Method Female Humans Hypertension - drug therapy Hypertension - physiopathology Lisinopril - therapeutic use Male Medical sciences Middle Aged Pharmacology. Drug treatments |
| title | Assessment of Antihypertensive Effect by Blood Pressure Monitoring: Applications to Bisoprolol and Lisinopril in a Double-Blind Study |
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