Pharmacokinetic and pharmacodynamic studies of ( R)-8-hydroxy-2-(di- n-propylamino)tetralin in the rat

Racemic 8-OH-DPAT, ( R,S)-8-hydroxy-2-(di- n-propylamino)tetralin, has become the prototype 5-HT 1A receptor agonist. The enantiomers of 8-OH-DPAT have similar affinities to the 5-HT 1A receptor, but the ( R)-enantiomer is a full agonist, whereas the ( S)-enantiomer is a partial agonist. This commun...

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