Free amino acid level determinations in normal and schizophrenic brain
1. Some disturbances in brain amino acids are reported with regard to pathological changes in schizophrenia: a reduction in GABA content and a reduced activity at some glutamatergic synapses. 2. Comparison of post-mortem brain tissue from control subjects and schizophrenic patients can provide evide...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 1989, Vol.13 (1), p.119-126 |
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| container_title | Progress in neuro-psychopharmacology & biological psychiatry |
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| creator | Kutay, Fatma Z. Pöǧün, Sakire I.Hariri, Nuran Peker, Gönül ErlaÇin, Sermet |
| description | 1. Some disturbances in brain amino acids are reported with regard to pathological changes in schizophrenia: a reduction in GABA content and a reduced activity at some glutamatergic synapses.
2. Comparison of post-mortem brain tissue from control subjects and schizophrenic patients can provide evidence for amino acid alterations in disease.
3. The present study was undertaken to measure free amino acid concentrations in 20 brain regions obtained at autopsy, from normal persons and schizophrenics. Amino acids were extracted, esterified and separated by gas chromatography.
4. The distribution and levels of amino acids in normal persons is in accordance with similar values reported in human post-mortem brain samples by other investigators.
5. The differences in amino acids found in schizophrenic brain samples support the view of disturbed neurotransmission especially with regard to GABAergic and glutamatergic systems in schizophrenia and suggest the possible involvement of other amino acids as well. |
| doi_str_mv | 10.1016/0278-5846(89)90008-0 |
| format | Article |
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2. Comparison of post-mortem brain tissue from control subjects and schizophrenic patients can provide evidence for amino acid alterations in disease.
3. The present study was undertaken to measure free amino acid concentrations in 20 brain regions obtained at autopsy, from normal persons and schizophrenics. Amino acids were extracted, esterified and separated by gas chromatography.
4. The distribution and levels of amino acids in normal persons is in accordance with similar values reported in human post-mortem brain samples by other investigators.
5. The differences in amino acids found in schizophrenic brain samples support the view of disturbed neurotransmission especially with regard to GABAergic and glutamatergic systems in schizophrenia and suggest the possible involvement of other amino acids as well.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/0278-5846(89)90008-0</identifier><identifier>PMID: 2748856</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Aged ; Amino acid levels ; Amino Acids - analysis ; Biological and medical sciences ; Biomarkers - analysis ; Brain Chemistry ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Organ Specificity ; post-mortem human brain ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Reference Values ; schizophrenia ; Schizophrenia - metabolism</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 1989, Vol.13 (1), p.119-126</ispartof><rights>1989</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-980af9544e7945e0bffc959acb8af1ee03da19e6028436e88f8208ac942da32d3</citedby><cites>FETCH-LOGICAL-c386t-980af9544e7945e0bffc959acb8af1ee03da19e6028436e88f8208ac942da32d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0278-5846(89)90008-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6770435$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2748856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kutay, Fatma Z.</creatorcontrib><creatorcontrib>Pöǧün, Sakire</creatorcontrib><creatorcontrib>I.Hariri, Nuran</creatorcontrib><creatorcontrib>Peker, Gönül</creatorcontrib><creatorcontrib>ErlaÇin, Sermet</creatorcontrib><title>Free amino acid level determinations in normal and schizophrenic brain</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>1. Some disturbances in brain amino acids are reported with regard to pathological changes in schizophrenia: a reduction in GABA content and a reduced activity at some glutamatergic synapses.
2. Comparison of post-mortem brain tissue from control subjects and schizophrenic patients can provide evidence for amino acid alterations in disease.
3. The present study was undertaken to measure free amino acid concentrations in 20 brain regions obtained at autopsy, from normal persons and schizophrenics. Amino acids were extracted, esterified and separated by gas chromatography.
4. The distribution and levels of amino acids in normal persons is in accordance with similar values reported in human post-mortem brain samples by other investigators.
5. The differences in amino acids found in schizophrenic brain samples support the view of disturbed neurotransmission especially with regard to GABAergic and glutamatergic systems in schizophrenia and suggest the possible involvement of other amino acids as well.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Amino acid levels</subject><subject>Amino Acids - analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Brain Chemistry</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Organ Specificity</subject><subject>post-mortem human brain</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Reference Values</subject><subject>schizophrenia</subject><subject>Schizophrenia - metabolism</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFKAzEQhoMotVbfQCEHET2sJrvZ3eQiSLEqFLzoOUyTWYzsZmuyLejTm9rSo6eB-b_5GT5Czjm75YxXdyyvZVZKUV1LdaMYYzJjB2TMZVqLnFeHZLxHjslJjJ-J4QUrRmSU10LKshqT2SwgUuic7ykYZ2mLa2ypxQFDWsLgeh-p89T3oYOWgrc0mg_30y8_Anpn6CKA86fkqIE24tluTsj77PFt-pzNX59epg_zzBSyGjIlGTSqFAJrJUpki6YxqlRgFhIajsgKC1xhxXIpigqlbGTOJBglcgtFbosJudr2LkP_tcI46M5Fg20LHvtV1LVKaniZJ1BsQRP6GAM2ehlcB-Fbc6Y3-vTGjd640VLpP32apbOLXf9q0aHdH-18pfxyl0M00DYBvHFxj1V1zURRJux-i2FysXYYdDQOvUHrAppB2979_8cvFieLYQ</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Kutay, Fatma Z.</creator><creator>Pöǧün, Sakire</creator><creator>I.Hariri, Nuran</creator><creator>Peker, Gönül</creator><creator>ErlaÇin, Sermet</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1989</creationdate><title>Free amino acid level determinations in normal and schizophrenic brain</title><author>Kutay, Fatma Z. ; Pöǧün, Sakire ; I.Hariri, Nuran ; Peker, Gönül ; ErlaÇin, Sermet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-980af9544e7945e0bffc959acb8af1ee03da19e6028436e88f8208ac942da32d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Amino acid levels</topic><topic>Amino Acids - analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Brain Chemistry</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Organ Specificity</topic><topic>post-mortem human brain</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Reference Values</topic><topic>schizophrenia</topic><topic>Schizophrenia - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kutay, Fatma Z.</creatorcontrib><creatorcontrib>Pöǧün, Sakire</creatorcontrib><creatorcontrib>I.Hariri, Nuran</creatorcontrib><creatorcontrib>Peker, Gönül</creatorcontrib><creatorcontrib>ErlaÇin, Sermet</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kutay, Fatma Z.</au><au>Pöǧün, Sakire</au><au>I.Hariri, Nuran</au><au>Peker, Gönül</au><au>ErlaÇin, Sermet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Free amino acid level determinations in normal and schizophrenic brain</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>1989</date><risdate>1989</risdate><volume>13</volume><issue>1</issue><spage>119</spage><epage>126</epage><pages>119-126</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>1. Some disturbances in brain amino acids are reported with regard to pathological changes in schizophrenia: a reduction in GABA content and a reduced activity at some glutamatergic synapses.
2. Comparison of post-mortem brain tissue from control subjects and schizophrenic patients can provide evidence for amino acid alterations in disease.
3. The present study was undertaken to measure free amino acid concentrations in 20 brain regions obtained at autopsy, from normal persons and schizophrenics. Amino acids were extracted, esterified and separated by gas chromatography.
4. The distribution and levels of amino acids in normal persons is in accordance with similar values reported in human post-mortem brain samples by other investigators.
5. The differences in amino acids found in schizophrenic brain samples support the view of disturbed neurotransmission especially with regard to GABAergic and glutamatergic systems in schizophrenia and suggest the possible involvement of other amino acids as well.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>2748856</pmid><doi>10.1016/0278-5846(89)90008-0</doi><tpages>8</tpages></addata></record> |
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| ispartof | Progress in neuro-psychopharmacology & biological psychiatry, 1989, Vol.13 (1), p.119-126 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Adult and adolescent clinical studies Aged Amino acid levels Amino Acids - analysis Biological and medical sciences Biomarkers - analysis Brain Chemistry Female Humans Male Medical sciences Middle Aged Organ Specificity post-mortem human brain Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Reference Values schizophrenia Schizophrenia - metabolism |
| title | Free amino acid level determinations in normal and schizophrenic brain |
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