Attenuation of nucleus basalis of Meynert lesion-induced cholinergic deficits by nerve growth factor
Nerve growth factor (NGF) was administered into either the lateral ventricle or into the basal forebrain of n. basalis of Meynert (nbM) lesioned rats. Rats received either continuous infusion of 5 μg of 7S NGF per day for 28 days, or 5 μg of 7S NGF on 4 occasions distributed evenly during the first...
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| Veröffentlicht in: | Brain research 1989-05, Vol.487 (1), p.200-203 |
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| creator | Haroutunian, V. Kanof, P.D. Davis, K.L. |
| description | Nerve growth factor (NGF) was administered into either the lateral ventricle or into the basal forebrain of n. basalis of Meynert (nbM) lesioned rats. Rats received either continuous infusion of 5 μg of 7S NGF per day for 28 days, or 5 μg of 7S NGF on 4 occasions distributed evenly during the first two post-lesion weeks. The administration of NGF reduced lesion-induced cortical cholinergic marker deficits by approximately 50%, irrespective of the locus or mode of NGF administration. Thus NGF is able to attenuate lesion-induced cholinergic deficits across a range of treatment and lesion conditions. |
| doi_str_mv | 10.1016/0006-8993(89)90960-8 |
| format | Article |
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Rats received either continuous infusion of 5 μg of 7S NGF per day for 28 days, or 5 μg of 7S NGF on 4 occasions distributed evenly during the first two post-lesion weeks. The administration of NGF reduced lesion-induced cortical cholinergic marker deficits by approximately 50%, irrespective of the locus or mode of NGF administration. Thus NGF is able to attenuate lesion-induced cholinergic deficits across a range of treatment and lesion conditions.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(89)90960-8</identifier><identifier>PMID: 2752286</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Acetylcholinesterase ; Animals ; Basal Ganglia - drug effects ; Basal Ganglia - physiology ; Biochemistry and metabolism ; Biological and medical sciences ; Central nervous system ; Choline acetyltransferase ; Cholinergic Fibers - drug effects ; Cholinergic Fibers - physiology ; Fundamental and applied biological sciences. Psychology ; Male ; Nerve growth factor ; Nerve Growth Factors - pharmacology ; Nerve Regeneration - drug effects ; Nucleus basalis of Meynert ; Rats ; Rats, Inbred Strains ; Time Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1989-05, Vol.487 (1), p.200-203</ispartof><rights>1989 Elsevier Science Publishers B.V. (Biomedical Division)</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-d601868ba2d8244ea38edbde86900abfde0fe0c78cbe5ebb8f7916c85421fe8e3</citedby><cites>FETCH-LOGICAL-c418t-d601868ba2d8244ea38edbde86900abfde0fe0c78cbe5ebb8f7916c85421fe8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0006899389909608$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19523751$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2752286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haroutunian, V.</creatorcontrib><creatorcontrib>Kanof, P.D.</creatorcontrib><creatorcontrib>Davis, K.L.</creatorcontrib><title>Attenuation of nucleus basalis of Meynert lesion-induced cholinergic deficits by nerve growth factor</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Nerve growth factor (NGF) was administered into either the lateral ventricle or into the basal forebrain of n. basalis of Meynert (nbM) lesioned rats. Rats received either continuous infusion of 5 μg of 7S NGF per day for 28 days, or 5 μg of 7S NGF on 4 occasions distributed evenly during the first two post-lesion weeks. The administration of NGF reduced lesion-induced cortical cholinergic marker deficits by approximately 50%, irrespective of the locus or mode of NGF administration. Thus NGF is able to attenuate lesion-induced cholinergic deficits across a range of treatment and lesion conditions.</description><subject>Acetylcholinesterase</subject><subject>Animals</subject><subject>Basal Ganglia - drug effects</subject><subject>Basal Ganglia - physiology</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Choline acetyltransferase</subject><subject>Cholinergic Fibers - drug effects</subject><subject>Cholinergic Fibers - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Nerve growth factor</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>Nerve Regeneration - drug effects</subject><subject>Nucleus basalis of Meynert</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvFSEUhUmjqa-1_6AmbDTtYhSYGeayadI0tjWpcWPXhIFLi5k3VGBq3r-X53upO91AuOc7J-RcQk45-8gZl58YY7IBpdozUOeKKckaOCArDoNopOjYK7J6Qd6Qo5x_1GfbKnZIDsXQCwFyRdxlKTgvpoQ40-jpvNgJl0xHk80U8nb0FTczpkInzBVqwuwWi47axziFKjwESx36YEOptg2to2ekDyn-Ko_UG1tiekteezNlPNnfx-T--vP3q9vm7tvNl6vLu8Z2HErjJOMgYTTCgeg6NC2gGx2CVIyZ0TtkHpkdwI7Y4ziCHxSXFvpOcI-A7TH5sMt9SvHngrnodcgWp8nMGJesh9oSSCn-C_K-5RKgr2C3A22KOSf0-imFtUkbzZnebkFvK9bbiuuh_2xBQ7W92-cv4xrdi2lfe9Xf73WTrZl8MrMN-W-26kU79LxyFzsOa2vPAZPONuBc6w8JbdEuhn9_5DeubqWe</recordid><startdate>19890515</startdate><enddate>19890515</enddate><creator>Haroutunian, V.</creator><creator>Kanof, P.D.</creator><creator>Davis, K.L.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19890515</creationdate><title>Attenuation of nucleus basalis of Meynert lesion-induced cholinergic deficits by nerve growth factor</title><author>Haroutunian, V. ; Kanof, P.D. ; Davis, K.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-d601868ba2d8244ea38edbde86900abfde0fe0c78cbe5ebb8f7916c85421fe8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Acetylcholinesterase</topic><topic>Animals</topic><topic>Basal Ganglia - drug effects</topic><topic>Basal Ganglia - physiology</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Choline acetyltransferase</topic><topic>Cholinergic Fibers - drug effects</topic><topic>Cholinergic Fibers - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Nerve growth factor</topic><topic>Nerve Growth Factors - pharmacology</topic><topic>Nerve Regeneration - drug effects</topic><topic>Nucleus basalis of Meynert</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haroutunian, V.</creatorcontrib><creatorcontrib>Kanof, P.D.</creatorcontrib><creatorcontrib>Davis, K.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haroutunian, V.</au><au>Kanof, P.D.</au><au>Davis, K.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Attenuation of nucleus basalis of Meynert lesion-induced cholinergic deficits by nerve growth factor</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1989-05-15</date><risdate>1989</risdate><volume>487</volume><issue>1</issue><spage>200</spage><epage>203</epage><pages>200-203</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Nerve growth factor (NGF) was administered into either the lateral ventricle or into the basal forebrain of n. basalis of Meynert (nbM) lesioned rats. Rats received either continuous infusion of 5 μg of 7S NGF per day for 28 days, or 5 μg of 7S NGF on 4 occasions distributed evenly during the first two post-lesion weeks. The administration of NGF reduced lesion-induced cortical cholinergic marker deficits by approximately 50%, irrespective of the locus or mode of NGF administration. Thus NGF is able to attenuate lesion-induced cholinergic deficits across a range of treatment and lesion conditions.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2752286</pmid><doi>10.1016/0006-8993(89)90960-8</doi><tpages>4</tpages></addata></record> |
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| ispartof | Brain research, 1989-05, Vol.487 (1), p.200-203 |
| issn | 0006-8993 1872-6240 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcholinesterase Animals Basal Ganglia - drug effects Basal Ganglia - physiology Biochemistry and metabolism Biological and medical sciences Central nervous system Choline acetyltransferase Cholinergic Fibers - drug effects Cholinergic Fibers - physiology Fundamental and applied biological sciences. Psychology Male Nerve growth factor Nerve Growth Factors - pharmacology Nerve Regeneration - drug effects Nucleus basalis of Meynert Rats Rats, Inbred Strains Time Factors Vertebrates: nervous system and sense organs |
| title | Attenuation of nucleus basalis of Meynert lesion-induced cholinergic deficits by nerve growth factor |
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