Chronic expression of murine flt3 ligand in mice results in increased circulating white blood cell levels and abnormal cellular infiltrates associated with splenic fibrosis

The effect of chronic expression of flt3 ligand (FL) on in vivo hematopoiesis was studied. Retroviral vector-mediated gene transfer was used in a mouse model of bone marrow transplantation to enforce expression of mouse FL cDNA in hematopoietic tissues. As early as 2 weeks posttransplantation, perip...

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Veröffentlicht in:	Blood 1997-07, Vol.90 (1), p.76-84
Hauptverfasser:	JUAN, T. S.-C, MCNIECE, I. K, FLETCHER, F. A, VAN, G, LACEY, D, HARTLEY, C, MCELROY, P, SUR, Y, ARGENTO, J, HILL, D, YAN, X.-Q
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Cell Count Cell Differentiation - genetics Cell differentiation, maturation, development, hematopoiesis Cell Lineage Cell Movement - genetics Cell physiology Fibrosis - genetics Fibrosis - pathology Fundamental and applied biological sciences. Psychology Gene Expression Gene Expression Regulation Leukocytes - pathology Male Membrane Proteins - biosynthesis Membrane Proteins - genetics Mice Mice, Inbred Strains Molecular and cellular biology Spleen - pathology
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